Voltage-Dependent Sodium and Calcium Currents in Acutely Isolated Adult Rat Trigeminal Root Ganglion Neurons

Kim, Hyung-Chan; Chung, Man‐Kyo

doi:10.1152/jn.1999.81.3.1123

Cited by 48 publications

(26 citation statements)

References 28 publications

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“…Pioneering studies showed that tetrodotoxin (TTX) and local anesthetic bupivacaine application on the IO nerve did not affect barrelette formation in the rat PrV (Henderson et al, 1992). More recent studies uncovered that trigeminal ganglion cells have TTXresistant Na ϩ and voltage-dependent Ca 2ϩ channels that produce Ca 2ϩ spikes (Kim and Chung, 1999;Cabanes et al, 2002). Furthermore, TTX or bupivacaine does not appear to block spontaneous activity of trigeminal ganglion cells Shoykhet et al, 2003).…”

Section: Physiological Evidence For Activity-dependent Plasticity In mentioning

confidence: 99%

Conversion of Functional Synapses into Silent Synapses in the Trigeminal Brainstem after Neonatal Peripheral Nerve Transection

Lo¹,

Erzurumlu²

2007

J. Neurosci.

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One of the major consequences of neonatal infraorbital nerve damage is irreversible morphological reorganization in the principal sensory nucleus (PrV) of the trigeminal nerve in the brainstem. We used the voltage-clamp technique to study synaptic transmission in the normal and the denervated PrV of neonatal rats in an in vitro brainstem preparation. Most of the synapses in the PrV are already functional at birth. Three days after peripheral deafferentation, functional synapses become silent, lacking AMPA receptor-mediated currents. Without sensory inputs from the whiskers, silent synapses persist through the second postnatal week, indicating that the maintenance of AMPA receptor function depends on sensory inputs. High-frequency (50 Hz) electrical stimulation of the afferent pathway, which mimics sensory input, restores synaptic function, whereas low-frequency (1 Hz) stimulation has no effect. Application of glycine, which promotes AMPA receptor exocytosis, also restores synaptic function. Therefore, normal synaptic function in the developing PrV requires incoming activity via sensory afferents and/or enhanced AMPA receptor exocytosis. Sensory deprivation most likely results in AMPA receptor endocytosis and/or lateral diffusion to the extrasynaptic membrane.

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Section: Physiological Evidence For Activity-dependent Plasticity In mentioning

confidence: 99%

Conversion of Functional Synapses into Silent Synapses in the Trigeminal Brainstem after Neonatal Peripheral Nerve Transection

Lo¹,

Erzurumlu²

2007

J. Neurosci.

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“…Later studies documented that TG cells have TTX-resistant Na ϩ channels and voltage-dependent Ca 2ϩ channels that produce Ca 2ϩ spikes (Kim and Chung, 1999;Cabanes et al, 2002). Spontaneous activity in the TG is also not blocked by TTX or bipuvicaine (Shoykhet et al, 2000(Shoykhet et al, , 2003Minnery et al, 2003).…”

Section: Neural Activitymentioning

confidence: 99%

Molecular determinants of the face map development in the trigeminal brainstem

2006

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The perception of external sensory information by the brain requires highly ordered synaptic connectivity between peripheral sensory neurons and their targets in the central nervous system. Since the discovery of the whisker-related barrel patterns in the mouse cortex, the trigeminal system has become a favorite model for study of how its connectivity and somatotopic maps are established during development. The trigeminal brainstem nuclei are the first CNS regions where whisker-specific neural patterns are set up by the trigeminal afferents that innervate the whiskers. In particular, barrelette patterns in the principal sensory nucleus of the trigeminal nerve provide the template for similar patterns in the face representation areas of the thalamus and subsequently in the primary somatosensory cortex. Here, we describe and review studies of neurotrophins, multiple axon guidance molecules, transcription factors, and glutamate receptors during early development of trigeminal connections between the whiskers and the brainstem that lead to emergence of patterned face maps. Studies from our laboratories and others' showed that developing trigeminal ganglion cells and their axons depend on a variety of molecular signals that cooperatively direct them to proper peripheral and central targets and sculpt their synaptic terminal fields into patterns that replicate the organization of the whiskers on the muzzle. Similar mechanisms may also be used by trigeminothalamic and thalamocortical projections in establishing patterned neural modules upstream from the trigeminal brainstem. The somatotopic map forms sequentially, beginning at the periphery and ending in the primary somatosensory cortex. In some species, such as rodents, neural modules form within the CNS body maps that correspond to patterned distribution of the sensory receptors in the periphery. In the mouse and rat muzzle, whiskers and sinus hairs are patterned in discrete arrays with constant numbers in each row of follicles (Yamakado and Yohro, 1979;Dörfl, 1985;Rice et al., 1986Rice et al., , 1993Brecht et al., 1997). The infraobital nerve (ION) of the trigeminal ganglion (TG) innervates the whisker pad and relays the whiskerrelated information to the principal sensory nucleus (PrV) in the brainstem, which in turn conveys the signals to the thalamus and the cortex via ascending afferents. The trigeminal brainstem complex also contains the spinal trigeminal nucleus, including subnuclei oralis (SpVo), inter-*Correspondence to: Reha S. Erzurumlu,

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“…Таким чином, зменшення концентрації кальцію в зовнішньоклітинному розчині приз водить до модуляції електричної актив-ності нейронів ГТН. Пригнічення горба на фазі реполяризації та зниження порогу гене-рації свідчить про наявність низькопорогових та високопорогових кальцієвих каналів [20]. Зміни у слідовій гіперполяризації та частот-них характеристиках вказують на активність кальційзалежних калієвих каналів [21].…”

Section: результати та їх обговоренняunclassified

“…Така різниця додатково доводить, що імпульсній активності ноцицепторів властива нечутливість до ТТХ [11]. Експресія в мембрані потенціалзалежних кальцієвих та ТТХ-резистивних натрієвих каналів може бути причиною генерації відповідей за наявності ТТХ [11,20]. Отримані результати збігаються з даними експериментів in vivo на нейронах ГТН миші, у яких спостерігалося повне або часткове пригнічення імпульсної активності за наявності ТТХ у сомах Aδ-волокон.…”

Section: результати та їх обговоренняunclassified