Voltage-Gated Ca&lt;sub&gt;v&lt;/sub&gt;1 Channels in Disorders of Vision and Hearing

Joiner, Mei-ling A.; Lee, Amy

doi:10.2174/1874467208666150507104937

Cited by 31 publications

(34 citation statements)

References 76 publications

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“…This contrasts with retinal photoreceptors, which do express Ca v 1.3, but rely on Ca v 1.4 for calcium influx (Matthews and Fuchs, 2010; Joiner and Lee, 2015). The pore-forming (alpha) subunit of Ca v 1.3 is encoded by Cacna1d , which is required for hearing (Platzer et al, 2000; Dou et al, 2004; Baig et al, 2011), and also for hair cell function in zebrafish (Nicolson et al, 1998; Sidi et al, 2004), where it is expressed in both neuromasts and the inner ear (Sidi et al, 2004).…”

Section: Resultsmentioning

confidence: 93%

“…These tether glutamate-filled synaptic vesicles and stabilize L-type voltage-gated calcium channels at the plasma membrane (Ca v 1.3 in hair cells; Ca v 1.4, in retinal photoreceptors; Joiner and Lee, 2015), enabling rapid and sustained glutamate release in response to activation of these calcium channels by membrane depolarization (Matthews and Fuchs, 2010; Pangršič et al, 2012; Safieddine et al, 2012; Nicolson, 2015; Wichmann and Moser, 2015; Moser and Starr, 2016). Electroreceptors also have synaptic ribbons of varying morphology (Northcutt, 1986; Bodznick and Montgomery, 2005): in paddlefish, they were described as synaptic ‘sheets’ (Jorgensen et al, 1972).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, retinal and pineal photoreceptors express Vglut1 and Vglut2 and neuronal SNAREs, and retinal photoreceptors depend on Ca v 1.4 (see e.g. Zanazzi and Matthews, 2009; Matthews and Fuchs, 2010; Mercer and Thoreson, 2011; Joiner and Lee, 2015). These physiological similarities between electroreceptors and hair cells are consistent with the expression in developing ampullary organs of key hair cell transcription factor genes, some of which presumably control the expression of ribbon synapse-associated genes in both electroreceptors and hair cells.…”

Section: Discussionmentioning

confidence: 99%

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Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Modrell

Lyne

Carr

et al. 2017

eLife

171

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The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor Xenopus is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish (Polyodon spathula). Validation of a subset reveals expression in developing ampullary organs of transcription factor genes critical for hair cell development, and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiological and evolutionary links between non-teleost electroreceptors and hair cells. We identify an ampullary organ-specific proneural transcription factor, and candidates for the voltage-sensing L-type Cav channel and rectifying Kv channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology. Overall, our results illuminate ampullary organ development, physiology and evolution.DOI: http://dx.doi.org/10.7554/eLife.24197.001

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Modrell

Lyne

Carr

et al. 2017

eLife

171

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“…However, an adaptation process based solely on vesicular exhaustion would be limited by vesicle pool replenishment rates during incoming sound stimulations. (5) Fast Ca 2+ current inactivation, due to intracellular Ca 2+ -dependent inactivation (Grant and Fuchs, 2008; Johnson and Marcotti, 2008; Joiner and Lee, 2015) of short C-term Ca V 1.3 isoforms (Vincent et al, 2017; Pangrsic et al, 2018), could also contribute to ANF firing adaptation. However, this Ca 2+ dependent inactivation can contribute only within a slower range of tens of milliseconds to the ANF firing adaptation.…”

Section: Discussionmentioning

confidence: 99%

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

et al. 2018

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SUMMARY A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells. Here we show that a robust ICaTB occurs at post-hearing mouse and gerbil inner hair cell (IHC) synapses, but not in immature IHC synapses, which contain non-compact active zones, where Ca2+ channels are loosely coupled to the release sites. Unlike ICaTB at other ribbon synapses, ICaTB in mammalian IHCs displays a surprising multi-peak structure that mirrors the EPSCs seen in paired recordings. Desynchronizing vesicular release with intracellular BAPTA or by deleting otoferlin, the Ca2+ sensor for exocytosis, greatly reduces ICaTB, whereas enhancing release synchronization by raising Ca2+ influx or temperature increases ICaTB. This suggests that ICaTB is produced by fast multivesicular proton-release events. We propose that ICaTB may function as a submillisecond feedback mechanism contributing to the auditory nerve’s fast spike adaptation during sound stimulation.

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“…They constitute different parts of the ERG. The major L-type voltage-gated Ca 2+ channel at the photoreceptor synapses is Ca v 1.4 in both retinal rods and cones [49]. T-type currents have been recorded in retinal bipolar cells [50].…”

Section: Transretinal Signaling Of Neuronal Networkmentioning

confidence: 98%

Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

Albanna¹,

Lüke²,

Alpdogan³

et al. 2018

New Front Ophthalmol

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Purpose: The isolated and superfused retina from vertebrates is routinely used for neurophysiological measurements of basic retinal signal generation and transduction. Such an ex vivo isolated neural network moreover represents a useful model system for the investigation of drugs and toxins and may also be helpful to elucidate molecular mechanisms of CNS diseases. The present overview aims to bring observations to the reader's attention, which, in part, have been made more than 50 years ago and were sparsely followed up upon in subsequent research, but may support the idea that the isolated bovine retina represents a useful system to investigate the physiology and pathophysiology of energy supply to neuronal tissue. Material and methods:Parallel recording of ERGs and pyridine nucleotide oxidation in the isolated and superfused vertebrate retina. The review will focus on topics, which discuss the connection between retinal electrophysiology and underlying energy metabolism.Results: Previous and present reports about (i) transretinal signaling cascades, (ii) the involvement of the pharmacoresistant Cav2.3 / R-type calcium channel in transretinal signaling and (iii) data about the retinal oxygen demands and concentration in different layers are collected, which elucidate that the retina may be used as a cerebral surrogate model in different research areas. Retinal tolerance to ischemia is several times larger than the tolerance in the remaining brain. Conclusions:The retinal energy supply through retinal vessels is regulated and controlled by neurovascular coupling. Classical retinal recording techniques and special retinal abilities in electrical-vascular coupling will be set in perspective with novel recording techniques, currently brought into clinical application for the detection of impaired neurovascular coupling after aneurysmal subarachnoid hemorrhage in the brain. The present review elucidates that important pathophysiological aspects related to the upregulation of pharmacoresistant Cav2.3 / R-type calcium channels during SAH may be investigated in the isolated vertebrate retina. Ischemic tolerance in the vertebrate retinaThe oxygen consumption of the vertebrate retina on a per gram basis has been described as higher than that of the brain [1,2]. Oxygen cannot be "stored" in tissue so that a constant and adequate supply must be guaranteed to preserve function. Metabolic dysfunction regarding to impaired vascular supply is directly reflected by retinal oxygen saturation which can be detected noninvasively by dual wavelength fundus photography [3]. Normally, the oxygen saturation in retinal vessels differs along vascular segments and is higher in the macular region than retinal periphery [4]. Many retinal diseases are caused by a dysfunction of the vascular network. Interestingly, the venous oxygen saturation in diabetic retinopathy was higher in venules draining the macular surroundings than retinal periphery that reflect specific metabolic conditions [5,6].Since a relatively unobstructed light path...

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Voltage-Gated Ca<sub>v</sub>1 Channels in Disorders of Vision and Hearing

Cited by 31 publications

References 76 publications

Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses

Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

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