Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders
Isabel E. Faulkner,
Rachael Z. Pajak,
Michael K. Harte
et al.
Abstract:Voltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they are causal to synaptic transmission, alterations to the structure of these channels can lead to a variety of neurological and psychiatric diseases. The Kv3 subfamily of voltage-gated potassium channels are found on many neurons in the brain, including inhibito… Show more
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