Voltage-gated sodium channel epilepsies in a tertiary care center: Phenotypic spectrum with correlation to predicted functional effects

Kurekci, Fulya; Akif Kilic, Mehmet; Akbas, Sinan; Avci, Rıdvan; Oney, Ceyda; Dilruba Aslanger, Ayca; Maras Genc, Hulya; Aydinli, Nur; Pembegul Yildiz, Edibe

doi:10.1016/j.yebeh.2024.109930

Epilepsy & Behavior

2024

DOI: 10.1016/j.yebeh.2024.109930

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Voltage-gated sodium channel epilepsies in a tertiary care center: Phenotypic spectrum with correlation to predicted functional effects

Fulya Kurekci,

Mehmet Akif Kilic,

Sinan Akbas

et al.

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Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

Cao,

Zhou,

Guo

et al. 2024

Biomark Res

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Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it is of urgent need to explore other potential mechanism to develop a novel approach to delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), the versatile epigenetic regulators responsible for gene transcription via binding histones or non-histone substrates, have grabbed considerable attention in drug discovery. There are also substantial evidences supporting that aberrant expressions and/activities of HDAC isoforms are reported in epilepsy and HDAC inhibitors (HDACi) have been successfully utilized for therapeutic purposes in this condition. However, the specific mechanisms underlying the role of HDACs in epileptic progression have not been fully understood. Herein, we reviewed the basic information of HDACs, summarized the recent findings associated with the roles of diverse HDAC subunits in epilepsy and discussed the potential regulatory mechanisms by which HDACs affected the development of epilepsy. Additionally, we also provided a brief discussion on the potential of HDACs as promising therapeutic targets for epilepsy treatment, serving as a valuable reference for basic study and clinical translation in epilepsy field.

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Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

Cao,

Zhou,

Guo

et al. 2024

Biomark Res

View full text Add to dashboard Cite

show abstract

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Voltage-gated sodium channel epilepsies in a tertiary care center: Phenotypic spectrum with correlation to predicted functional effects

Cited by 1 publication

References 53 publications

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

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