Voltage-induced frequency drift correction in fourier transform electrostatic linear ion trap mass spectrometry using mirror-switching

Dziekonski, Eric T.; Johnson, Joshua T.; Hilger, Ryan T.; McIntyre, Catherine L.; Santini, R.; McLuckey, Scott A.

doi:10.1016/j.ijms.2016.10.012

Cited by 5 publications

(16 citation statements)

References 48 publications

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“…The ELIT utilized in this work has been described previously . Briefly, the ELIT captures ions via mirror-switching and detects the resulting image charge using a central detector.…”

Section: Methodsmentioning

confidence: 99%

“…All other plate potentials were generated by additional ORTEC 556 power supplies with typical trapping potentials being 2356 (plate 8), 1639 (plates 2 and 7), 1046 (plates 3 and 6), and −2106 V (plates 4 and 5) as measured with a calibrated 1000× probe and a HP 34401A multimeter. Frequency shifts arising from the transient voltage recovery of the pulsed power supply were compensated for using the published procedure . Daily variations in the output voltages of the power supplies were minimized by leaving the ORTECs on.…”

Section: Methodsmentioning

confidence: 99%

“…The charge sensitive detection electronics have been described previously. , The output of the charge sensitive preamplifier (A250, Amptek) was filtered (band-pass, Krohn-Hite Model 3940, Brockton, MA) and amplified (gain = 5) prior to digitization by a PCI-based digitizer (CS1621, 16-bit, Gage Applied Technologies, Lanchine, Quebec, Canada) at a rate of 10 MS/s (AC coupled, 1 MΩ input impedance, 25 MHz low-pass filter enabled). A program written in LabVIEW 13.0 (National Instruments, Austin, TX) was used to acquire the transient.…”

Section: Methodsmentioning

confidence: 99%

“…The Fourier transform electrostatic linear ion trap (FT-ELIT) is a type of mass analyzer in which ions are trapped between two axially opposing reflectrons. ,− As the ion packet oscillates back and forth, the image charge induced on a centrally located detector is amplified and digitized. The frequency components are derived from the recorded transient via a fast Fourier transform algorithm and calibrated to generate a mass spectrum.…”

mentioning

confidence: 99%

“…This leads to a pressure of ∼3 × 10 −9 Torr in the analyzer (measured with a Granville Phillips 355001-YF ion gauge and displayed on a Granville Phillips 358 Micro-Ion controller). Relative to the previous instrument design, 27 the differentially pumped region was removed, and the accumulation quadrupole was placed in the main chamber. While this modification led to a greater base pressure in the ELIT, the transmission efficiency of the ion path was greatly increased.…”

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confidence: 99%

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Utility of Higher Harmonics in Electrospray Ionization Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometry

2017

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Mass resolution (M/ΔM fwhm) is observed to linearly increase with harmonic order in a Fourier transform electrostatic linear ion trap (ELIT) mass spectrometer. This behavior was predicted by Grosshans and Marshall for frequency-multiple detection in a Fourier transform ion cyclotron resonance mass spectrometer only for situations when the prominent mechanism for signal decay is ion ejection from the trap. As the analyzer pressure in our ELIT chamber is relatively high, such that collisional scattering and collision-induced dissociation are expected to underlie much of the ion loss, we sought to explore the relationship between harmonic order and mass resolution. Mass resolutions of 36 900 (fundamental), 75 850 (2nd harmonic), and 108 200 (3rd harmonic) were obtained for GdO (avg. m/z 173.919) with a transient length of 300 ms. To demonstrate that the mass resolution was truly increasing with harmonic order, the unresolved isotopes at the fundamental distribution of cytochrome c (m/z ∼ 1549) were nearly baseline, resolved at the third harmonic (mass resolution ≈ 23 000) with a transient length of only 200 ms. This experiment demonstrates that, when the ion density is sufficiently low, ions with frequency differences of less than 4 Hz remain uncoalesced. Higher harmonics can be used to increase the effective mass resolution for a fixed transient length and thereby may enable the resolution of closely spaced masses, determination of a protein ion's charge state, and study of the onset of peak coalescence when the resolution at the fundamental frequency is insufficient.

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“…The ELIT utilized in this work has been described previously . Briefly, the ELIT captures ions via mirror-switching and detects the resulting image charge using a central detector.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Utility of Higher Harmonics in Electrospray Ionization Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometry

2017

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Determination of Collision Cross Sections Using a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer

Dziekonski

Johnson

Lee

et al. 2017

J. Am. Soc. Mass Spectrom.

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Collision cross sections (CCSs) were determined from the frequency-domain linewidths in a Fourier transform electrostatic linear ion trap. With use of an ultrahigh-vacuum precision leak valve and nitrogen gas, transients were recorded as the background pressure in the mass analyzer chamber was varied between 4× 10 and 7 × 10 Torr. The energetic hard-sphere ion-neutral collision model, described by Xu and coworkers, was used to relate the recorded image charge to the CCS of the molecule. In lieu of our monoisotopically isolating the mass of interest, the known relative isotopic abundances were programmed into the Lorentzian fitting algorithm such that the linewidth was extracted from a sum of Lorentzians. Although this works only if the isotopic distribution is known a priori, it prevents ion loss, preserves the high signal-to-noise ratio, and minimizes the experimental error on our homebuilt instrument. Six tetraalkylammonium cations were used to correlate the CCS measured in the electrostatic linear ion trap with that measured by drift-tube ion mobility spectrometry, for which there was an excellent correlation (R ≈ 0.9999). Although the absolute CCSs derived with our method differ from those reported, the extracted linear correlation can be used to correct the raw CCS. With use of [angiotensin II] and reserpine, the corrected CCSs (334.9 ± 2.1 and 250.1 ± 0.5, respectively) were in good agreement with the reported ion mobility spectrometry CCSs (335 and 254.3, respectively). With sufficient signal-to-noise ratio, the CCSs determined are reproducible to within a fraction of a percent, comparable to the uncertainties reported on dedicated ion mobility instruments. Graphical Abstract ᅟ.

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A Miniaturized Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer: Mass Range and Resolution

Johnson

Lee

Bhanot

et al. 2019

J. Am. Soc. Mass Spectrom.

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Voltage-induced frequency drift correction in fourier transform electrostatic linear ion trap mass spectrometry using mirror-switching

Cited by 5 publications

References 48 publications

Utility of Higher Harmonics in Electrospray Ionization Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometry

Utility of Higher Harmonics in Electrospray Ionization Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometry

Determination of Collision Cross Sections Using a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer

A Miniaturized Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer: Mass Range and Resolution

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