As the use of photovoltaics becomes more widespread, new technologies for more efficient energy generation, transmission, and distribution based on power electronics converters are being developed. The most common applications are grid-on, energy storage, hybrid, and high voltage gain applications. These applications impose several additional requirements in the design of power converters associated with the solar battery’s maximum power tracking and operation in a wide range of input currents and voltages. The practical realization of such solutions can be implemented on the basis of various topologies, which requires a preliminary application of criteria for assessing their effectiveness. The paper conducts a comparison of different topologies on power converters based on two parameters that describe their cost and power loss for various PV applications. For a straightforward study, these parameters are represented using the gain factor, which allows for an accurate comparison of the efficiency of various types of converters.