Voltammetric Detection of Captopril in a Commercial Drug Using a Gold‐Copper Metal‐organic Framework Nanocomposite Modified Electrode

Abstract

We report the application of an electrochemical sensor based on gold‐copper metal‐organic framework immobilized on the surface of a glassy carbon electrode to the detection of captopril (CAP), an angiotensin‐converting enzyme inhibitor. Cyclic voltammetric studies showed that the joint action of gold nanoparticles and copper‐1,3,5‐benzenetricarboxylate (Cu−BTC) enhanced the electrochemical response to the Cu‐captopril complex that is adsorbed onto the surface of the electrode. Release of gold nanoparticles from Au@Cu−BTC not only increased the conductivity of the electrode but also provided a more favorable environment for the deposition of reduced Cu that is catalytically renewed on the electrode surface. The anodic current of the Cu(II)−CAP oxidation peak varied linearly within two concentration ranges, namely 0.5 to 7.0 μmol L−1 and 10 to 2500 μmol L−1, with a limit of detection of 0.047 μmol L−1. The mean recovery for the determination of captopril in commercial tablets was 100.3 % suggesting that the method has considerable potential for future industrial applications.

2‐Methylimidazole‐assisted Morphology Modulation of a Copper‐based Metal‐organic Framework Transducer for Enhanced Electrochemical Peroxidase‐like Activity

“…As shown in the cyclic voltammogram (Figure 4A), CuÀ BDC(NH 2 )@2-MI exhibited a pair of redox peaks at À 0.327 V and À 0.117 V (50 mV s À 1 , in 0.1 M PBS, pH 7.0), respectively ascribed to the conversion between Cu I and Cu II [25,26]. When a series of scan rates from 20 mV s À 1 to 100 mV s À 1 were applied, the intrinsic electrochemical redox kinetics of CuÀ BDC(NH 2 )@2-MI began to appear.…”

Efficient Uptake of Angiotensin-Converting Enzyme II Inhibitor Employing Graphene Oxide-Based Magnetic Nanoadsorbents

“…Although this medicine is effective for control of diseases, around 50% of CPT is excreted by kidneys in unchanged form, contributing to water contamination [7]. Additionally, this pharmaceutical compound may cause diverse side effects and toxicity to organisms [8,9].…”