Voltammetric Detection of Damage to DNA by Arsenic Compounds at a DNA Biosensor

Heavy Metals Content in Paraphilometroides nemipteri from South China Sea may Influence Level of Glutathione and P38 Protein Expression

“…A high amount of arsenic could lead to the oxidative stress (Labuda et al 2005). According to Rios-Barrera et al (2008), heavy metals such as cadmium and mercury exhibited p38 MAPK activity that mediates redox stress of the MAPKK signal pathways in Euglena gracilis.…”

Chapter 7. Detection of Damage to DNA Using Electrochemical and Piezoelectric DNA-Based Biosensors

“…Various DNA-modified carbon electrodes such as GCE, pyrolytic graphite electrode (PGE), CPE, and disposable screen-printed carbon electrode (SPCE) were also utilized and effects of genotoxic agents such as hydrazines, 64 platinum compounds, 65 metal complexes, 66 various aromatic compounds, 67,68 arsenic compounds, 69,70 and UV light 71 were detected. Decrease of the anodic guanine peak height or area relative to that yielded by intact DNA was suggested as a measure representing damage to this nucleobase.…”

“…Thus, the proportion of DNA that has survived incubation of the biosensor in the cleavage agent can be estimated. 34,68,69 Sensitive electrochemical sensing for DNA damage in situ based on a cathodic process with a Fe@Fe 2 O 3 core-shell nanonecklace and gold nanoparticles was performed by a novel biosensor, which was constructed via a GCE modified with a multilayer film made up of separate layers of PDDA, the mixture of Fe@Fe 2 O 3 core-shell nanonecklace and gold nanoparticles, PDDA, and dsDNA. 91 Iron ions and H 2 O 2 (Fenton reagents) were generated continuously at a constant rate by the cathodic process.…”

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

“…In most cases, electrochemical investigation of the interaction between pharmaceuticals and DNA involves the induction of changes in the redox properties of the pharmaceuticals, since these organic 1,2 or inorganic [3][4][5][6] substances often contain electrochemically active functional groups in their chemical structures.…”