Voltammetric Determination of Betulin in the Extracts of Plant Origin

Kaliyeva, Samal; Слепченко, Г. Б.; Akeneev, Yu. A.; Nurpeiis, Ye. E.; Ташенов, А. К.; Мамаева, Е. А.; Бакибаев, А. А.

doi:10.1134/s0020168518140108

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…It has been shown that the insufficient purity of substances isolated from extracts or reaction mass containing target substances is a serious hindrance for voltametric studies [115] during the determination of antioxidant activity as well as the further chemical modifications of triterpenes. Obviously, such studies dictate the need for simple ways to clean them from accompanying impurities.…”

Section: Chromatographic and Other Methodsmentioning

confidence: 99%

Methods of Analysis and Identification of Betulin and Its Derivatives

Takibayeva,

Zhumabayeva,

Bakibaev

et al. 2023

Molecules

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This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin.

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Section: Chromatographic and Other Methodsmentioning

confidence: 99%

Methods of Analysis and Identification of Betulin and Its Derivatives

Takibayeva,

Zhumabayeva,

Bakibaev

et al. 2023

Molecules

View full text Add to dashboard Cite

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Application of a new electrochemical sensor for voltammetric determination of p-nitrophenol and betulin

Nurpeiis

Слепченко²,

Bogoslovski³

et al. 2023

Zavod. lab., Diagn. mater.

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A highly sensitive electrochemical sensor based on a Surface Active Modifier (SAM) consisting of Taunit-M carbon nanotubes and mesoporous carbon (NanoTechCenter LLC, Tambov, Russia) is developed for the voltammetric determination of betulin and p-nitrophenol. The effect of the modifier concentration on the electrode surface on the analytical signal of betulin was studied, and a method for modifying the surface of the SAM graphite electrode was developed. The developed method is easy to use, fast, stable, sensitive, and cost-effective procedure, which can be used to detect these analytes in real samples. Voltammograms of p-nitrophenol were obtained for the first time on the developed modified electrochemical sensor and the dependence of the height of its analytical signal on the pH of a phosphate buffer thus obtained was studied in a wide pH range from 4 to 12, a background electrolyte with optimal pH was also chosen. Proceeding from the calibration dependences of the height of the betulin analytical signal on the concentration obtained for various background electrolytes with different pH and cation-anion composition, a background electrolyte with the maximum sensitivity of the analytical signal was selected on a modified electrochemical sensor. Study of cyclic voltammograms was carried out to understand the electrode processes, exhibiting a pronounced peak of anodic oxidation observed in a potential range from 0.7 to 0.9 V. However, there was no peak in the cathodic direction which indicates the irreversible nature of the electrode process. When determining the nature of currents, the Semerano criterion equal to 1.6 was calculated, which indicates the absence of the contribution of the diffusion component of the current. Verification of the correctness of the voltammetric method for determining betulin on a new electrochemical sensor was carried out using the «spike-test» method. The data obtained show that the voltammetric determination of betulin can be carried out with a measurement error not exceeding 15%. The proposed modified electrodes were compared with previously known electrodes for the determination of pentacyclic triterpenoids and pesticides at concentrations of 0.5 × 10–3 – 8.0 × 10–3 mg/dm3.

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Voltammetric Determination of Betulin in the Extracts of Plant Origin

Cited by 2 publications

References 5 publications

Methods of Analysis and Identification of Betulin and Its Derivatives

Methods of Analysis and Identification of Betulin and Its Derivatives

Application of a new electrochemical sensor for voltammetric determination of p-nitrophenol and betulin

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