Voltammetric determination of itopride using carbon paste electrode modified with Gd doped TiO2nanotubes

Abstract

In the present work TiO 2 nanotubes (TNT) have been synthesized by alkaline hydrothermal transformation. Then they have been doped with Gd element. Characterizations of doped and undoped TNT have been done with TEM and SEM. The chemical composition was analyzed by EDX, Raman and FTIR spectroscopy. The crystal structure was characterized by XRD. Carbon paste electrode has been fabricated and mixed with Gd doped and undoped TNT to form a nanocomposite working electrode. Comparison of bare carbon paste electrode and Gd doped and undoped TNT carbon paste electrode for 1.0 ×10 −3 M K 4 [Fe(CN) 6 ] voltammetric analysis; it was observed that Gd doped TNT modified electrode has advantage of high sensitivity. Gd doped TNT modified electrode has been used as working electrode for itopride assay in a pharmaceutical formulation. Cyclic voltammetry analysis showed high correlation coefficient of 0.9973 for itopride (0.04-0.2 mg/mL) with a limit of detection (LOD) and limit of quantitation values (LOQ) of 2.9 and 23.0 µg.mL −1 respectively.

Fabrication and Characterization of Lanthanide-TiO<sub>2</sub> Nanotube Composites

“…This was in good agreement with the XRD data and Open Journal of Physical Chemistry previous work. The E g peak was attributed mainly to the symmetric stretching vibration of O-Ti-O linkages in TiO 2 , the symmetric bending vibration of O-Ti-O was confirmed by B 1g , and the A 1g peak was associated with the antisymmetric bending vibration of the O-Ti-O linkage [33]. The same strong peaks observed in The band at 278 cm −1 was assigned to the stretching vibration of Ti-O-K bonds [45], while the bands at 198 cm −1 and 394 cm −1 corresponded to anatase Ti-O-Ti [43].…”

“…The effects of these lanthanides on the structural, textural, and morphological properties of TiO 2 nanomaterials obtained after calcination of hydrogen titanate nanotubes were investigated. The synthesized TNT, Nd and/or Gd-TNT show different applications, such as great performance of electro-oxidation of hydrazine by electrosensory [32] and determination of pharmaceutical compound as Alendronate sodium [33].…”

Simple Sensor Application: Determination of Electrochemical Properties of Carvedilol in CPE Based on Zinc Oxide Nanoparticles and Development of the Method for its Determination in Pharmaceutical Samples

“…The significant incre-slow electron transfer. The addition of metal oxide nanoparticles to the CP mixture is promising to overcome the existing disadvantages of CP [16][17][18][19][20][21]. Nanotechnology is an interdisciplinary field used by many scientists.…”

Investigation of Electrochemical Properties of UA At Al2O3NP/CPE and Development of Voltammetric Method for its Determination in Serum

“…However, these electrodes have several drawbacks such as low sensitivity, slow electron transfer, the need for higher overpotential for the electrocatalytic process. Incorporation of metal oxide nanoparticles into the carbon paste mixture is a promising approach to overcome these limitations [9][10][11][12].…”