Voltammetric determination of sibutramine in beverages and in pharmaceutical formulations

Abstract

Recebido em 6/10/11; aceito em 30/11/11; publicado na web em 23/1/12 A simple and sensitive method has been proposed for the determination of sibutramine-HCl in energy drinks, green tea and pharmaceutical formulations using differential pulse voltammetry performed on a hanging mercury drop electrode. In the chosen experimental condition (Mcllvaine pH 4.0 buffer, 50 mV pulse amplitude and 40 mV s -1 scan velocity), sibutramine-HCl presented a reversible behavior and a peak maximum at -80 mV. Detection limit was 0.4 mg L -1 and the working linear range extended up to 33.3 mg L -1 (r = 0.99). Analysis of real and fortified samples enabled recoveries between 91 and 102%. The electroanalytical method was compared with a HPLC method which indicated it accuracy.

Simple and Sensitive Determination of Sibutramine in Slimming Tea Beverages Using a Carbon Screen‐printed Electrode with Adsorptive Stripping Voltammetry

“…Although many analytical techniques have been reported for the determination of sibutramine in natural product samples used for weight‐loss , only a few methods have been applied to slimming tea beverages . Fast and low‐cost methods using electroanalytical techniques have been used for sibutramine determination in tea samples based on the voltammetric detection at a boron‐doped diamond electrode (BDDE) or a hanging mercury drop electrode (HMDE) . Beside these electrodes, a modified glassy carbon electrode (GCE) using microextraction‐assisted voltammetry of microparticles with multivariate chemometric techniques was reported for screening in adulterated tea beverages .…”

Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine

“…Carvalho et al have reported the voltammetric investigation of SHM at a hanging mercury drop electrode (HMDE) and its determination in beverages and pharmaceutical formulations. 26 This method involves the use of mercury based electrodes. The electrochemical behavior of SHM at bare GCE and modied GCE (ERGO-GCE) has not been studied so far, neither has its evaluation as a sensor to quantify SHM by differential pulse voltammetry been attempted.…”

Enantiomeric Separation of Sibutramine by Capillary Zone Electrophoresis

“…Structurally sibutramine is an amine (pKa = -8.5) and, consequently, can be detected in an acidic environment, where sibutramine will be positively charged. 15 Several BGEs with different compositions (phosphate, borate buffers) over a wide pH range (2-12) were studied. The pH of the buffer was adjusted with 1.0 mol L −1 sodium hydroxide or 1.0 mol L −1 phosphoric acid.…”