Voltammetric quantitation at the mercury electrode of the anticholinergic drug flavoxate hydrochloride in bulk and in a pharmaceutical formulation

Abstract

Abstract:Flavoxate hydrochloride, 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4-H-chromene-8-carboxylate, is a smooth muscle antispasmodic. Its electrochemical behavior was studied at the mercury electrode in buffered solutions containing 30% (v/v) methanol using dc-polarography, differential-pulse polarography, cyclic voltammetry, and linear sweep-and square-wave adsorptive stripping voltammetry. Sensitive and precise procedures were developed for determination of bulk flavoxate hydrochloride and in the pharmaceutical formulation Genurin R S.F, without sample pretreatment or extraction. Limits of quantitation (LOQ) of 1 × 10 −5 , 5 × 10 −6 , 1 × 10 −8 and 1 × 10 −9 M flavoxate hydrochloride were achieved by dc-polarography, differential-pulse polarography, linear sweep and square-wave adsorptive stripping voltammetric, respectively.

Plastic membrane electrodes for the determination of flavoxate hydrochloride and cyclopentolate hydrochloride

“…It prevents spasms in the urinary tract and relieves painful or difficult urination, urinary urgency, excessive nighttime urination, pubic area pain, frequent urination and the inability to hold urine caused by urinary tract infections [2]. FxCl has been studied by ultraviolet spectrophotometry [3,4], high performance liquid chromatography [5][6][7], voltammetric quantitation with a mercury electrode [8], 1 H and 13 C NMR [9], assay methods in blood and urine [10] and potentiometric determination [11]. The official methods for the determination of FxCl, non-aqueous titration using perchloric acid as a titrant and spectrophotometry [4], were carried out and compared with our electrodes.…”

3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid

“…hydrochloride (Uneyama et al, 1985). The flavoxate hydrochloride is a smooth muscle antispasmodic, especially on the urogenital tract (Ghoneim et al, 2007). We report here the crystal structure of the title compound.…”

“…For related literature, see: Uneyama et al (1985); Ghoneim et al (2007); Da Re (1960Re ( , 1968; Sianesi (1972). Mo K radiation = 0.10 mm À1 T = 298 (2) K 0.35 Â 0.27 Â 0.18 mm…”

Liquid Chromatographic Determination of Solifenacin Succinate, Flavoxate Hydrochloride and Tolterodine Tartrate in Bulk Drugs and Their Pharmaceutical Dosage Forms

“…for the determination of FLXHC [37,38], spectroflourimetric [39] and electrochemical voltammetric methods for the determination of FLXHC [40] and TOLT [41,42] were reported for their determination in bulk, dosage forms and biological fluids.…”