Voltammetric studies on the antibiotic drug cefoperazone

Hammam, Essam; El-Attar, Mona A.; Beltagi, A. M.

doi:10.1016/j.jpba.2006.05.002

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…This is different from the attribution of cefoperazone irreversible electrode reaction by Hammam and coworkers to the reduction of an electroactive group in the sidechain on C-7 [18]. …”

Section: Resultscontrasting

confidence: 64%

“…Although voltammetric techniques were also used for this purpose [18–21], the electroanalytical mechanism of cefoperazone was not clearly presented as well as its determination in the presence of sulbactam not being investigated. This work aimed at presenting a validated, simple, and sensitive adsorptive stripping voltammetric procedure for the quantification of cefoperazone in pharmaceutical formulations and spiked human urine, in particular overcoming the above-mentioned drawbacks in voltammetrically studied cefoperazone.…”

Section: Introductionmentioning

confidence: 99%

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Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine

Hoang

Huyen²,

Phuc³

2013

Journal of Analytical Methods in Chemistry

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The electroreduction behaviour and determination of cefoperazone using a hanging mercury drop electrode were investigated. Cyclic voltammograms of cefoperazone recorded in universal Britton-Robinson buffers pH 3–6 exhibited a single irreversible cathodic peak. The process was adsorption-controlled. Britton-Robinson buffer 0.04 M pH 4.0 was selected as a supporting electrolyte for quantitative purposes by differential pulse and square wave adsorptive cathodic stripping voltammetry. The experimental voltammetric conditions were optimized using Central Composite Face design. A reduction wave was seen in the range from −0.7 to −0.8 V. These voltammetric techniques were successfully validated as per ICH guidelines and applied for the determination of cefoperazone in its single and sulbactam containing powders for injection and statistically comparable to USP-HPLC. They were further extended to determine cefoperazone in spiked human urine with no matrix effect.

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“…This is different from the attribution of cefoperazone irreversible electrode reaction by Hammam and coworkers to the reduction of an electroactive group in the sidechain on C-7 [18]. …”

Section: Resultscontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine

Hoang

Huyen²,

Phuc³

2013

Journal of Analytical Methods in Chemistry

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“…The electrochemical experiments, weighing the solid materials, the used deionized water and convective transport during the preconcentration step were performed using the same equipment that described in the refs. [1,[24][25][26]]. An automatic micropipette (Eppendorf-Multipette® plus) was used to transferring analyte solutions.…”

Section: Apparatusmentioning

confidence: 99%

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

El-Attar

Ghoneim

2020

Egypt. J. Chem.

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The electrochemical behavior of anti-hyperglycemic (glibenclamide, GBC) was investigated and discussed at HMDE in Britton-Robinson universal buffer using cyclic voltammetry. Its voltammogram at pH values 6-11 displayed a quasi-reversible redox couple one-electron peak corresponding to a catalytic hydrogen process. Based on this voltammetric peak, a validated and sensitive SW-AdCS voltammetric method was depicted for determination of GBC in the bulk form, diabetic drug (Daonil  5 mg) and in human serum. The (LOD) of 6×10 -9 M (2.964 ng mL 1 ) and (LOQ) of 2×10 8 M (9.88 ng mL 1 ) bulk GBC were achieved, respectively, While for protein-free GBC-spiked human serum were (LOD) of 1.5x10 -8 M (7.41 ng mL -1 ) and limit of quantification (LOQ) of 5x10 -8 M (24.7 ng mL -1 ), respectively. The described analytical method was utilized to estimate the pharmacokinetic parameters of GBC in plasma of hospitalized volunteers after the administration of a single oral dose of Daonil  5 mg (p  0.05).

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“…CEF and sulbactam were determined in plasma also by LC-MS/MS method [ 12 ]. Additionally, electrochemical behavior and voltammetric determination of CEF [ 13 , 14 ] were reported.…”

Section: Introductionmentioning

confidence: 99%

Determination of Cefoperazone Sodium in Presence of Related Impurities by Linear Support Vector Regression and Partial Least Squares Chemometric Models

Naguib

Abdelaleem

Zaazaa

et al. 2015

Journal of Analytical Methods in Chemistry

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A comparison between partial least squares regression and support vector regression chemometric models is introduced in this study. The two models are implemented to analyze cefoperazone sodium in presence of its reported impurities, 7-aminocephalosporanic acid and 5-mercapto-1-methyl-tetrazole, in pure powders and in pharmaceutical formulations through processing UV spectroscopic data. For best results, a 3-factor 4-level experimental design was used, resulting in a training set of 16 mixtures containing different ratios of interfering moieties. For method validation, an independent test set consisting of 9 mixtures was used to test predictive ability of established models. The introduced results show the capability of the two proposed models to analyze cefoperazone in presence of its impurities 7-aminocephalosporanic acid and 5-mercapto-1-methyl-tetrazole with high trueness and selectivity (101.87 ± 0.708 and 101.43 ± 0.536 for PLSR and linear SVR, resp.). Analysis results of drug products were statistically compared to a reported HPLC method showing no significant difference in trueness and precision, indicating the capability of the suggested multivariate calibration models to be reliable and adequate for routine quality control analysis of drug product. SVR offers more accurate results with lower prediction error compared to PLSR model; however, PLSR is easy to handle and fast to optimize.

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Voltammetric studies on the antibiotic drug cefoperazone

Cited by 19 publications

References 18 publications

Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine

Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

Determination of Cefoperazone Sodium in Presence of Related Impurities by Linear Support Vector Regression and Partial Least Squares Chemometric Models

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