Voltammetric study of levomepromazine induced ionic permeability in a model lipid membrane system

The Role of the Membrane Actions of Phenothiazines and Flavonoids as Functional Modulators

“…Morin (30), a flavonol with five polar unsubstituted hydroxyl groups, was shown to be one of the most effective inhibitors of BCPCF efflux. The concentration of morin (30) that caused 50% inhibition of MRP1 activity (IC 50 ) recorded in erythrocytes was lower than the IC 50 value obtained previously by Nguyen et al [226] in a cancer cell line overexpressing MRP1. Taking into account the IC 50 values, the potency of silybin (52) to inhibit BCPCF efflux was similar to that of morin (30) or licoisoflavone B (55) [233].…”

“…Quercetin (29) was found to be superior to rutin (50) in protecting erythrocytes against lipid peroxidation, reactive oxygen species formation, and in preserving cellular integrity. The two flavonoids performed similarly when alteration in membrane fluidity, lipid and glutathione loss, and percentage of hemoglobin oxidation were measured.…”

“…It might suggest that apart from the radical scavenging ability of flavonoids, their metal chelating properties were also important for liposome protection. The high effectiveness of quercetin (29) and rutin (50) in complexing Cu 2+ and Fe 2+ but not Pb 2+ ions in lipid bilayers was demon- strated by a spectrophotometric method [96]. Heart microsomes were used in the study of antioxidant and metal chelating properties of a large group of flavonoids [97].…”

“…Saija et al investigated the thermotropic behavior of DPPC bilayers in the presence of quercetin (29), naringenin (33), hesperetin (34) [124], and rutin (50) [84]. All flavonoids, with the exception of rutin (50), caused a concentration-dependent decrease of T m accompanied by the broadening of calorimetric peaks. None of the flavonoids changed the transition enthalpy of DPPC.…”

“…From these experiments it was deduced that phenothiazine derivatives tended to reduce the order of DPPC monolayers. Voltammetric study of levomepromazine (18) interaction with stable thin liquid films formed from lecithin on a glassy carbon electrode showed that the permeability of the model membrane to the small solutes was increased in the presence of the drug [50]. The effect of TDZ (6) on the transport of neurotransmitters and ions has been recently studied by Nagapa et al [51].…”