Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode

Fabrication of a nanostructure thin film on the gold electrode using continuous pulsed-potential technique and its application for the electrocatalytic determination of metronidazole

“…The linear sweep voltammetry on the rotating disk of pretreated gold electrode (with rotation speed of 1000 rpm) shows two lin- The detection limit, linear dynamic range and sensitivity for MTZ determination by this method, according to Table 1, are relatively better than other electrochemical methods reported by Ş entürk and co-workers [41], Qilong and co-workers [43] and Bartlett et al [45]. On the other hand, as compared to the published chromatographic and electrophoresis methods which require lengthy and tedious extraction procedures, this method does not require to any filtration for analysis of drugs from undissolved excipients and is rapid, sensitive and simple.…”

“…The biological activity of nitroimidazoles is dependent upon the nitro group reduction process due to the formation of active intermediate species that interact with DNA to produce biochemical damage [30]. A survey of literature reveals that there are various methods available for the determination of MTZ including spectrophotometry [31,32], titrimetry [33], thin-layer chromatography [34], gas chromatography [35], and high performance liquid chromatography [36], electrophoresis [37], and voltammetry [38][39][40][41][42][43][44][45][46]. Most of the spectrophotometric methods reported suffer from the disadvantages like narrow range of determination, requires heating or extraction, long time for the reaction to complete, use of nonaqueous systems and stability of the coloured product formed.…”

Biomimetic sensor based on copper-poly(cysteine) film for the determination of metronidazole

“…Since the intermediates formed during the reduction of metronidazole can kill the majority of anaerobic bacteria, metronidazole is often used for the treatment of trichomoniasis A C C E P T E D M A N U S C R I P T and giardiasis [2]. However, a growing number of studies have shown that the cytotoxicity of metronidazole allows it to be useful in the treatment of diseases also make it hazardous to the health of both humans and wildlife [3].…”

Simultaneous Determination of Clarithromycin, Tinidazole and Omeprazole in Helicure Tablets Using Reflectance Near-Infrared Spectroscopy with the Aid of Chemometry

“…These methods included titrimetry [3][4][5], spectrophotometry [6][7][8],spectrofluorimetry [9], electrochemical [10,11], polarography [12], high performance liquid chromatography (HPLC) with several detection techniques [13][14][15][16][17], thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) [18][19][20].…”