Volume and Emptying of the Gallbladder in Patients with Cystic Fibrosis

Santamaria, Francesca; Vajro, P.; Oggero, V.; Greco, Letizia; Angelillo, M; Carrillo, Francisco Ruiz; Ritis, G De

doi:10.1097/00005176-199004000-00006

Cited by 19 publications

(9 citation statements)

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“…36 Enlarged gallbladder volumes has been documented by ultrasonography in CF patients, 37 and 99m Tc-mebrofenin scintigraphic analyses showed that the gallbladder did not empty after a fatty meal in about half the CF patients tested. 38 In CF patients, including those without liver disease, the proportion of the primary BA cholic acid is higher than in controls, whereas those of the secondary BAs, lithocholic acid or deoxycholic acid, are lower.…”

Section: Discussionmentioning

confidence: 99%

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies

Debray¹,

Rainteau²,

Barbu³

et al. 2012

Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies

Debray¹,

Rainteau²,

Barbu³

et al. 2012

Gastroenterology

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“…In this study, SFM provided the stimulation necessary for GB contractility in the control group. USG is the most rapid, accurate and least-invasive diagnostic technique available for the evaluation of GB disease [15]. The USG assessment of the postprandial percentage of reduction of the GB as a method of evaluating GB function has already been employed in other diseases [10,15 Á20].…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

Çay¹,

İmamoğlu²,

Sarıhan³

et al. 2006

Acta Paediatrica

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Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction provides relatively reliable and reproducible results. Thus it can be used for scanning in patients with biliary symptoms as a prior modality to CCK-HBS since it is a relatively easier, safer and available method with which to make a definitive diagnosis of BD. The patients with symptoms of biliary disease and no evidence of gallstones on USG should be evaluated by the method proposed in this study before the routine laboratory and radiologic tests.

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“…USG is the most rapid, accurate and least‐invasive diagnostic technique available for the evaluation of GB disease 15. The USG assessment of the postprandial percentage of reduction of the GB as a method of evaluating GB function has already been employed in other diseases 1015–20.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

et al. 2006

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Aim: Biliary dyskinesia (BD) is characterized by symptoms of biliary disease, no evidence of gallstones on ultrasonography (USG), and diminished gallbladder ejection fraction. The diagnosis is based on findings of abnormal gallbladder ejection fraction diagnosed by hepatobiliary scintigraphy before and after stimulation of gallbladder contraction with cholecystokinin (CCK). We used an easier diagnostic technique defined as ultrasonographic evaluation of fatty meal stimulated gallbladder contraction, employing USG with the diagnosis of biliary dyskinesia in children. The study was conducted by USG to investigate the volume and contractility of the gallbladder (GB) in fasting conditions and 45 min after a standardized fatty meal (SFM) in normal children and in a group of BD patients, and to compare the diagnostic value of this test with scintigraphy and to evaluate its use as a new method in the diagnostic algorithm of BD. Methods: We assessed the volume changes and contractility of the GB in response to SFM by USG in 14 patients with BD diagnosed by cholecystokinin stimulated hepatobiliary scintigraphy (CCKs‐HBS); and compared them with 14 control patients matched for age and gender before cholecystectomy. After an overnight fasting, GB volume was measured by USG then the GB volume was again measured after the SFM ingestion. Using USG, length, width and height of GB were measured, and volume of the GB was calculated using the ‘Dodds’ formula. These volume measurements were used to calculate the percentage of gallbladder emptying (ejection fraction). Fasting, after SFM and EF values comparisons between groups were done with student's t‐test. Results: No statistically significant difference of fasting GB volumes were demonstrated between BD and control groups (14.1±6.7 cm3 and 13.4±4.0 cm3 respectively). GB volumes of the BD group after SFM were significantly greater than in healthy controls (13.1±1.8 cm3 and 3.4±0.9 cm3 respectively, P<0.0005). The calculated percentage of gallbladder contraction (ejection fraction) was found to be lower in BD patients than in healthy controls (7.1%±1.8% and 73.8%±6.4%, respectively, P<0.0005). Conclusion: Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction provides relatively reliable and reproducible results. Thus it can be used for scanning in patients with biliary symptoms as a prior modality to CCK‐HBS since it is a relatively easier, safer and available method with which to make a definitive diagnosis of BD. The patients with symptoms of biliary disease and no evidence of gallstones on USG should be evaluated by the method proposed in this study before the routine laboratory and radiologic tests.

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Volume and Emptying of the Gallbladder in Patients with Cystic Fibrosis

Cited by 19 publications

References 0 publications

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies

Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

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