Volume and Heterogeneity Dependence of the Dose-Response Relationship for Head And Neck Tumours

Cronqvist, Anna-Karin Ågren; Källman, Patric; Turesson, Ingela; Brahme, Anders

doi:10.3109/02841869509127196

Cited by 43 publications

(38 citation statements)

References 27 publications

(15 reference statements)

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“…A relationship that is formally similar to the one derived in Equation 4 above has previously been suggested to hold up as an approximate relationship at the steepest part of the dose-response curve in the special case of a Poisson dose-response model [15]. As shown here, this formula is valid irrespective of the details of the dose-response curve, at all response levels and without any approximation.…”

Section: Discussionsupporting

confidence: 53%

Steepness of the radiation dose-response curve for dose-per-fraction escalation keeping the number of fractions fixed

Bentzen

2005

Acta Oncologica

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Section: Discussionsupporting

confidence: 53%

Steepness of the radiation dose-response curve for dose-per-fraction escalation keeping the number of fractions fixed

Bentzen

2005

Acta Oncologica

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“…Due to its dependence on the effective clonogen number, γ should theoretically increase with tumor volume. This increase with tumor size was seen in clinical larynx cancer data by Ågren-Cronqvist et al (1995). Using an experimental mouse model, Khalil et al (1997) showed a slow increase in γ with tumor volume under ambient conditions.…”

Section: The Generalized Dose-response Gradientmentioning

confidence: 89%

Accurate description of heterogeneous tumors for biologically optimized radiation therapy

Nilsson

2005

Medical Physics

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In this thesis, a model of tissue oxygenation is presented, that takes into account the heterogeneous nature of tumor vasculature. Even though the model is rather simple, the resulting oxygen distributions agree very well with clinically observed oxygen distributions for most tumors and healthy normal tissues. The model shows that the vascular density may not describe the oxygenation of a tissue sufficiently well, unless the heterogeneity of the vascular system is taken into account. Based on the oxygen distributions from the tissue model, the associated radiation response at low and high doses can be determined.The radiation response of heterogeneous tumors should preferably be described by two clonogen compartments, one resistant and one sensitive, dominating the response at high and low radiation doses, respectively. Furthermore, each compartment should be characterized by the effective radiation resistance and the effective clonogen number. The resistant-sensitive model of radiation response has been analyzed in great detail. It accurately describes the response of severely heterogeneous tumors, both at low and high doses and LET values. The effective response parameters are given as integrals, averaged over the whole spectrum of radiation resistance. The parameters can also be determined from clinically established dose-response relations.The main properties of the dose-response relation for a generally heterogeneous tumor is described in some detail. The normalized dose-response gradient has been generalized to take heterogeneities in both dose delivery and radiation response into account. This quantity is important for accurate treatment plan optimization using intensity modulated radiation therapy for individual patients.

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“…The mechanistically-motivated model most often used to describe radiotherapeutic tumor control is the linear quadratic model [2][3][4][5][6][7], which has more recently been used to include heterogeneity, within and/or between tumors [23][24][25][26][27][28]. Consequently, as an example of a model which assumes that the same tumoricidal mechanisms operate at all radiation doses, we used the LQ model with heterogeneous tumor cell radiosensitivity (within a given tumor).…”

Section: Radiobiological Modelsmentioning

confidence: 99%

High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients

Shuryak¹,

Carlson²,

Brown³

et al. 2015

Radiotherapy and Oncology

117

107

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Volume and Heterogeneity Dependence of the Dose-Response Relationship for Head And Neck Tumours

Cited by 43 publications

References 27 publications

Steepness of the radiation dose-response curve for dose-per-fraction escalation keeping the number of fractions fixed

Steepness of the radiation dose-response curve for dose-per-fraction escalation keeping the number of fractions fixed

Accurate description of heterogeneous tumors for biologically optimized radiation therapy

High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients

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