Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder

Quigley, Stephen J.; Scanlon, Cathy; Kilmartin, Liam; Emsell, Louise; Langan, Camilla; Hallahan, Brian; Murray, Michael; Waters, C.; Waldron, Michael; Hehir, Sarah; Casey, Helen; McDermott, Emma; Ridge, Jason; Kenney, Joanne; O’Donoghue, Stefani; Nannery, Rory; Ambati, Srinath; McCarthy, Peter; Barker, Gareth J.; Cannon, Dara M.; McDonald, Colm

doi:10.1016/j.pscychresns.2015.05.012

Cited by 28 publications

(13 citation statements)

References 57 publications

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“…We also observed smaller grey-matter volumes in the right insula, right superior temporal region and median cingulate cortex, as well as larger grey-matter volume in the left supplementary motor area in patients with bipolar disorder during the depressive phase compared with healthy controls, although these alterations did not appear to be diagnos tically specific. In line with our findings, studies also reported smaller volumes in the left hippocampus 46 or lesser cortical thickness in the prefrontal areas, the left superior temporal cortex and the right ACC 47 in euthymic patients with bipolar disorder relative to healthy controls. Some within-subject MRI studies of patients with bipolar disorder revealed that, compared to patients in the euthymic phase, those in the depressive phase exhibited lower grey-matter density/volume in the PFC, ACC and left inferior parietal lobule, and greater grey-matter density in the subgenual PFC, left inferior temporal gyrus and parahippocampal gyrus.…”

Section: Grey-matter Alterations In Different Mood Statessupporting

confidence: 92%

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis

Wang

Luo

Tian

et al. 2019

jpn

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Background: The literature on grey-matter volume alterations in bipolar disorder is heterogeneous in its findings. Methods: Using effect-size differential mapping, we conducted a meta-analysis of grey-matter volume alterations in patients with bipolar disorder compared with healthy controls. Results: We analyzed data from 50 studies that included 1843 patients with bipolar disorder and 2289 controls. Findings revealed lower grey-matter volumes in the bilateral superior frontal gyri, left anterior cingulate cortex and right insula in patients with bipolar disorder and in patients with bipolar disorder type I. Patients with bipolar disorder in the euthymic and depressive phases had spatially distinct regions of altered grey-matter volume. Meta-regression revealed that the proportion of female patients with bipolar disorder or bipolar disorder type I was negatively correlated with regional grey-matter alteration in the right insula; the proportion of patients with bipolar disorder or bipolar disorder type I taking lithium was positively correlated with regional greymatter alterations in the left anterior cingulate/paracingulate gyri; and the proportion of patients taking antipsychotic medications was negatively correlated with alterations in the anterior cingulate/paracingulate gyri. Limitations: This study was cross-sectional; analysis techniques, patient characteristics and clinical variables in the included studies were heterogeneous. Conclusion: Structural greymatter abnormalities in patients with bipolar disorder and bipolar disorder type I were mainly in the prefrontal cortex and insula. Patients' mood state might affect grey-matter alterations. Abnormalities in regional grey-matter volume could be correlated with patients' specific demographic and clinical features.

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Section: Grey-matter Alterations In Different Mood Statessupporting

confidence: 92%

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis

Wang

Luo

Tian

et al. 2019

jpn

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“…The caudate nucleus facilitates cross talk between prefrontal–cortical networks and subserves behavioral adaptations required for achievement of complex goals ( 23 , 78 ). Studies investigating caudate volume between BD and controls have reported mixed findings with no differences ( 79 , 80 ) and decreased volume compared to controls ( 81 ). Decreased volume of the caudate has also been reported in women with major depressive disorder ( 82 ), this may suggest that women with comorbid BD and PMDD may display structural and functional brain changes that mirror aspects of depression.…”

Section: Discussionmentioning

confidence: 99%

Brain Structure and Function in Women with Comorbid Bipolar and Premenstrual Dysphoric Disorder

et al. 2018

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IntroductionHormonal fluctuations associated with female reproductive life events may precipitate or worsen affective episodes in women with bipolar disorder (BD). Previous studies have shown that women with BD report higher rates of premenstrual dysphoric disorder (PMDD) than controls. Further, bipolar women who report premenstrual worsening of mood display a worse course of their bipolar illness. Despite this, the neural correlates of comorbid BD and PMDD have not been investigated.MethodologyEighty-five [CTRL, n = 25; PMDD, n = 20; BD, n = 21; BD with comorbid PMDD (BDPMDD), n = 19], regularly cycling women, not on hormonal contraception, underwent two MRI scans: during their mid-follicular and late luteal menstrual phases. We investigated resting-state functional connectivity (Rs-FC), cortical thickness, and subcortical volumes of brain regions associated with the pathophysiology of BD and PMDD between groups, in the mid-follicular and late luteal phases of the menstrual cycle. All BD subjects were euthymic for at least 2 months prior to study entry.ResultsWomen in the BDPMDD group displayed greater disruption in biological rhythms and more subthreshold depressive and anxious symptoms through the menstrual cycle compared to other groups. Rs-FC was increased between the L-hippocampus and R-frontal cortex and decreased between the R-hippocampus and R-premotor cortex in BDPMDD vs. BD (FDR-corrected, p < 0.05). Cortical thickness analysis revealed decreased cortical thickness of the L-pericalcarine, L-superior parietal, R-middle temporal, R-rostral middle frontal, and L-superior frontal, as well as increased cortical thickness of the L-superior temporal gyri in BDPMDD compared to BD. We also found increased left-caudate volume in BDPMDD vs. BD (pCORR < 0.05).ConclusionWomen with BD and comorbid PMDD display a distinct clinical and neurobiological phenotype of BD, which suggests differential sensitivity to endogenous hormones.

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“…Smaller hippocampi are seen less commonly in BP than in SCZ ( Otten and Meeter, 2015 , van Erp et al, 2012 ). Shrinkage of the head and medial border of the left hippocampus has been reported in BP, along with expansion on the right hippocampal tail medially ( Quigley et al, 2015 ). Our study results also showed a relationship between clinical symptoms and smaller hippocampal volumes on the left side.…”

Section: Discussionmentioning

confidence: 99%

Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders

Mamah

Alpert

Deanna

et al. 2016

NeuroImage: Clinical

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BackgroundDisorders within the schizophrenia spectrum genetically overlap with bipolar disorder, yet questions remain about shared biological phenotypes. Investigation of brain structure in disease has been enhanced by developments in shape analysis methods that can identify subtle regional surface deformations. Our study aimed to identify brain structure surface deformations that were common across related psychiatric disorders, and characterize differences.MethodsUsing the automated FreeSurfer-initiated Large Deformation Diffeomorphic Metric Mapping, we examined volumes and shapes of seven brain structures: hippocampus, amygdala, caudate, nucleus accumbens, putamen, globus pallidus and thalamus. We compared findings in controls (CON; n = 40), and those with schizophrenia (SCZ; n = 52), schizotypal personality disorder (STP; n = 12), psychotic bipolar disorder (P-BP; n = 49) and nonpsychotic bipolar disorder (N-BP; n = 24), aged 15–35. Relationships between morphometric measures and positive, disorganized and negative symptoms were also investigated.ResultsInward deformation was present in the posterior thalamus in SCZ, P-BP and N-BP; and in the subiculum of the hippocampus in SCZ and STP. Most brain structures however showed unique shape deformations across groups. Correcting for intracranial size resulted in volumetric group differences for caudate (p < 0.001), putamen (p < 0.01) and globus pallidus (p < 0.001). Shape analysis showed dispersed patterns of expansion on the basal ganglia in SCZ. Significant clinical relationships with hippocampal, amygdalar and thalamic volumes were observed.ConclusionsFew similarities in surface deformation patterns were seen across groups, which may reflect differing neuropathologies. Posterior thalamic contraction in SCZ and BP suggest common genetic or environmental antecedents. Surface deformities in SCZ basal ganglia may have been due to antipsychotic drug effects.

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Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder

Cited by 28 publications

References 57 publications

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis

Brain Structure and Function in Women with Comorbid Bipolar and Premenstrual Dysphoric Disorder

Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders

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