Volume-based non-continuum modeling of bone functional adaptation

Wang, Zhengyuan; Mondry, Adrian

doi:10.1186/1742-4682-2-6

Cited by 8 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While it works for solid objects with small complexity, STL is an unfeasible format if internal pore architecture is an integral part of the computer-aided design (Melchels et al, 2012 ). New methods to create porous models from medical imaging-derived data are therefore under evaluation in order to enable the study of the effects of biomechanical forces on bone remodeling (Wang and Mondry, 2005 ).…”

Section: Clinical Translationmentioning

confidence: 99%

Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges

Orciani

Fini

Primio

et al. 2017

Front. Bioeng. Biotechnol.

111

View full text Add to dashboard Cite

The growing occurrence of bone disorders and the increase in aging population have resulted in the need for more effective therapies to meet this request. Bone tissue engineering strategies, by combining biomaterials, cells, and signaling factors, are seen as alternatives to conventional bone grafts for repairing or rebuilding bone defects. Indeed, skeletal tissue engineering has not yet achieved full translation into clinical practice because of several challenges. Bone biofabrication by additive manufacturing techniques may represent a possible solution, with its intrinsic capability for accuracy, reproducibility, and customization of scaffolds as well as cell and signaling molecule delivery. This review examines the existing research in bone biofabrication and the appropriate cells and factors selection for successful bone regeneration as well as limitations affecting these approaches. Challenges that need to be tackled with the highest priority are the obtainment of appropriate vascularized scaffolds with an accurate spatiotemporal biochemical and mechanical stimuli release, in order to improve osseointegration as well as osteogenesis.

show abstract

Section: Clinical Translationmentioning

confidence: 99%

Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges

Orciani

Fini

Primio

et al. 2017

Front. Bioeng. Biotechnol.

111

View full text Add to dashboard Cite

show abstract

“…Many simulations have examined the biomechanical properties of bone in an attempt to simulate gait [70], or the effect of implanted prosthesis on the surrounding bone tissue [71,72], with a focus on modeling biomechanical qualities. An increasing number of simulations [72][73][74][75][76] focus on such issues as bone metabolism in adaptative situations, ion flux, and the influence of pharmacologic intervention on bone turnover, to name but a few. In so far as bone metabolism depends on electrolyte homeostasis, a process long described by quantitative mathematical models as prominently demonstrated by Brown's formulation of the calcium set-point [77], the study of bone in health and disease lends itself to quantitative mathematical modeling.…”

Section: Simulation Of Bone Turnover: a Systems Biology Approachmentioning

confidence: 99%

Bone and the Kidney: A Systems Biology Approach to the Molecular Mechanisms of Renal Osteodystrophy

Mondry¹,

Wang²,

Dhar

2005

CMM

Self Cite

View full text Add to dashboard Cite

Despite its apparent static condition, the skeleton undergoes a permanent process of remodeling mediated by osteoblasts and osteoclasts. The activity of these cells is regulated by a plethora of factors, ranging from mechanical stress to the effects of hormones to the immune system. One well-studied regulatory system involves the maintenance of calcium homeostasis through a network whose main regulatory components include ionized calcium, phosphate, parathyroid hormone and active vitamin D. This system establishes the link between bone and kidney, as one of the kidney's endocrine functions is the activation of vitamin D, while electrolyte homeostasis is one of its excretory functions. Impaired renal function leads to disturbances in this regulatory system, resulting in the complex syndrome of renal osteodystrophy that affects the majority of patients with chronic renal failure. This review summarizes the current understanding of bone physiology on a molecular level, examines some of the pathological pathways related to renal disease, and concludes with an outlook on how the emerging field of systems biology may contribute to a more dynamic and quantitative understanding of the physiology and pathophysiology of renal bone disease.

show abstract

“…Bone transformation is a highly coordinated adaptation of the bone tissue, J. Wolff's stress trajectory hypothesis has been corroborated under relatively simple load FEA studies and is debated as there is currently a lack of consensus on the precise interpretation of stress trajectories in trabecular and cortical bone in complex load scenarios, as discussed by J. Skedros [43]. We are only beginning to understand the mechanical work of bone due to advances in computational models such as analytical discrete methods [44].…”

Section: Hierarchical Differentiation Of Fibrous Arrangementsmentioning

confidence: 99%

Hierarchical Structures Computational Design and Digital 3D Printing

Borunda¹,

Anaya

2023

Journal of the International Association for Shell and Spatial

View full text Add to dashboard Cite

Current advances in construction automation, especially in large-scale additive manufacturing, highlight the vast potential for robots in architecture. Robotic construction is unique in its potential to reproduce highly complex structures. To advance the question of how rapid prototyping techniques are adopted in large-scale 3D printing of forms and structures, this paper presents computational methods for the design and robotic construction of cellular membranes. This research presents a comprehensive morphological model of structurally differentiated cellular membranes based on the theoretical biology model of hierarchical structures found in natural cellular solids, and, more specifically, in trabecular bone. The morphological model originates from a system of forces in equilibrium; therefore, it presents the geometric homology of a static tensional system. This research offers a methodology for the design and manufacture of meso- to large-scale triangulated geometric configurations by discrete design methods that are suitable for the robotic fused deposition of lattices and their architectural implementation in the automated manufacturing of shell structures. First, this paper explores how a form can be digitally created by geometrically emulating a given static system of forces in space. Second, inspired by the complex mechanical behavior of cancellous bone, we apply hierarchical principles found in bone remodeling to characterize discrete units that conform to continuous trabecular-like lattices. We study the geometry, limitations, opportunities for optimization, and mechanical characteristics of the lattice. The computational design methods and additive manufacturing techniques are tested in the design and construction hierarchical structures.

show abstract

Volume-based non-continuum modeling of bone functional adaptation

Cited by 8 publications

References 32 publications

Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges

Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges

Bone and the Kidney: A Systems Biology Approach to the Molecular Mechanisms of Renal Osteodystrophy

Hierarchical Structures Computational Design and Digital 3D Printing

Contact Info

Product

Resources

About