“…Gaies et al (12,13) showed that maximum VIS is a predictor of morbidity and mortality after pediatric cardiopulmonary bypass, whereas McIntosh et al (14) found that the VIS in sepsis is independently associated with PICU length of stay and ventilator days. Other studies have also shown a relationship between increasing vasopressor dosing and increased mortality in septic shock (21,22). To our knowledge, our study is the first to evaluate the trajectories of the VIS in shock and their association with outcomes.…”