Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)

Balducci, Stefano; Cardelli, Patrizia; Pugliese, Luca; D’Errico, Valeria; Haxhi, Jonida; Alessi, Elena; Iacobini, Carla; Menini, Stefano; Bollanti, Lucilla; Conti, Francesco; Nicolucci, Antonio; Pugliese, Giuseppe

doi:10.1016/j.diabres.2015.05.033

Cited by 36 publications

(35 citation statements)

References 37 publications

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“…Diabetes status was sometimes an inclusion criterion16 17 but more often a reason for exclusion 18 20 22 24 28 29 32. The majority of trials included participants of both genders (age 18–75), with the percentage participation of each sex varying across the studies, although a minority included exclusively male36 or female35 subjects.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of trials included participants of both genders (age 18–75), with the percentage participation of each sex varying across the studies, although a minority included exclusively male36 or female35 subjects. Five interventions involving exercise also excluded those who were physically unable to complete the protocol 17 29 30 32 34. All but one of the interventions assessing exercise without dietary modification required participants to have been sedentary prior to the intervention 30.…”

Section: Resultsmentioning

confidence: 99%

“…All but one of the interventions assessing exercise without dietary modification required participants to have been sedentary prior to the intervention 30. The trials took place in a wide range of geographical locations; however, only four studies specified ethnicity as an inclusion/exclusion criterion 16 17 20 33…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review

Kenneally

Sier

Moore

2017

BMJ Open Gastroenterol

109

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BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, with prevalence above 30% in many adult populations. Strongly associated with obesity, weight loss through diet and physical activity is the mainstay of its management. Weight loss can be difficult to achieve and maintain however, and uncertainty exists as to which lifestyle changes are most effective.ObjectiveThe aim of this work was to systematically evaluate randomised controlled trials assessing diet, exercise or combination interventions aimed at reducing steatosis or markers of NAFLD activity.DesignMedline, Scopus and Cochrane databases were searched from 1 January 1980 through to 31 July 2016, for intervention trials assessing the effects of diet, weight loss, exercise or any combination thereof, on NAFLD disease markers in human adults. Risk of publication bias and study quality was assessed using the American Dietetic Association Quality Criteria Checklist.ResultsFrom a total of 1710 identified records, 24 articles met the inclusion and exclusion criteria; 6 assessed weight loss using dietary restriction, 10 assessed exercise and 8 were combination interventions. While all of the trials demonstrated significant reduction in steatosis and/or markers of NAFLD activity, combination interventions appear to be the most effective at improving NAFLD. Results suggest that 5–10% weight loss using a modestly hypocaloric diet of 500 kcal less per day than calculated energy requirement, in combination with 30–60 min exercise on 3–5 days per week should be recommended.ConclusionsWe conclude this amount of weight loss is achievable in the trial setting but is challenging in the clinical environment. High-intensity, multidisciplinary intervention in specialist clinics is likely to be required in order to manage NAFLD by lifestyle modification alone. This systematic review protocol was registered prospectively at PROSPERO as CRD42016032764.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review

Kenneally

Sier

Moore

2017

BMJ Open Gastroenterol

109

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“…As a result, enzymes levels did not change, whereas FLI and VAI decreased significantly in counseling group, but not in counseling alone participants. So, physical activity volume was an independent predictor of both FLI and VAI reductions and a decrease in these variables with supervised training occurs in a volume-dependent manner [21].…”

Section: Discussionmentioning

confidence: 99%

“…Investigating the same modalities, [21] evaluated levels of liver enzymes, fatty liver index (FLI), and visceral adiposity index (VAI) in 606 sedentary patients with DM2. Participants were assigned to supervised aerobic and resistance training plus structured exercise counseling or counseling alone for 12 months.…”

Section: Discussionmentioning

confidence: 99%

Resistance and Aerobic Training in the Treatment of Type 2 Diabetes Mellitus

Nunes¹

2017

JDMDC

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Diabetes Mellitus is considered a chronic disease of epidemic proportions that affects approximately 415 million adults. Several studies reported the benefits of exercise training for this syndrome treatment. The aim of this study was to summarize the major findings of aerobic, resistance, and combined training influence in patients with Type 2 Diabetes Mellitus. The studies showed that different modalities of exercise exert positive effects on insulin sensitivity, exercise capacity, glycemic control, vascular function, and other risk factors associated with Type 2 Diabetes Mellitus. As a conclusion, physical exercise is a safe and effective strategy to prevent and mitigate the changes associated with Type 2 Diabetes Mellitus, besides it is possible to get benefits with continuous aerobic (low, moderate or high intensity), interval, combined or resistance training.

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The mediating role of visceral adiposity in the relationship among schooling, physical inactivity, and unhealthy metabolic phenotype

Ferreira

Juvanhol

Silva-Costa

et al. 2020

American J Hum Biol

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Objective: To explore the mediating role of visceral adiposity, as assessed by the visceral adiposity index (VAI), in the relationship among schooling, physical inactivity, and unhealthy metabolic phenotype (UMP). Methods: A cross-sectional population-based study was conducted with 854 adult individuals of both sexes from a Brazilian city. Data were collected through interviews, anthropometric evaluation, and clinical and laboratorial tests. We used multivariate path analysis, which simultaneously analyzes multiple relationships between variables. The analyses were adjusted by sex and age and stratified according to nutritional status. Results: A positive direct effect of visceral adiposity on the UMP was observed for normal weight, standardized estimate (SE) = 0.632; confidence interval (CI 95%) = 0.547, 0.707) and overweight individuals (SE = 0.732; CI 95% = 0.647, 0.808), and negative direct effect of schooling on physical inactivity (normal weight: SE = −0.408; CI 95% = −0.550, −0.265) and overweight (SE = −0.304; CI 95% = −0.479, −0.129). Among normal-weight individuals, there was a positive direct effect (SE = 0.193; CI 95% = 0.059, 0.328) of physical inactivity on VAI. In relation to indirect effects, there was a mediating role of visceral adiposity in the association of schooling level and physical inactivity with the UMP only among normal-weight individuals. Conclusions: Visceral adiposity has a direct effect on the UMP regardless of nutritional status, and there is a mediating effect of VAI on the relationship among schooling, physical inactivity, and UMP in normal-weight individuals.

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Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)

Cited by 36 publications

References 37 publications

Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review

Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review

Resistance and Aerobic Training in the Treatment of Type 2 Diabetes Mellitus

The mediating role of visceral adiposity in the relationship among schooling, physical inactivity, and unhealthy metabolic phenotype

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