Volume expansions and vapor-liquid equilibria of binary mixtures of a variety of polar solvents and certain near-critical solvents

Kordikowski, Andreas; Schenk, A.P.; Nielen, R.M. Van; Peters, Cor J.

doi:10.1016/0896-8446(95)90033-0

Cited by 313 publications

(259 citation statements)

References 4 publications

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“…The swelling of the liquid phase of a molecular liquid upon injection of a gas under pressure is a thermodynamic observable of importance in chemical engineering studies. [112][113][114][115][116] To quantify the liquid phase swelling, we have calculated the evolution of the relative volume expansion V/V of the liquid phase of CS 2 with the CO 2 concentration from the molar volumes v m and v CS 2 of the mixture and pure CS 2 , respectively. 116 The evolution of V/V of the mixture closely follows the calculated V/V = x CO 2 v CO 2 / (x CS 2 v CS 2 ) which is valid for an ideal mixture for which the volume additivity applies (see Fig.…”

Section: Discussion On the Non-ideal Behaviour Of The Mixturementioning

confidence: 99%

Assessing the non-ideality of the CO2-CS2 system at molecular level: A Raman scattering study

Besnard

Cabaço²,

Coutinho

et al. 2013

The Journal of Chemical Physics

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The dense phase of CO 2 -CS 2 mixtures has been analysed by Raman spectroscopy as a function of the CO 2 concentration (0.02-0.95 mole fractions) by varying the pressure (0.5 MPa up to 7.7 MPa) at constant temperature (313 K). The polarised and depolarised spectra of the induced (ν 2 , ν 3 ) modes of CS 2 and of the ν 1 -2ν 2 Fermi resonance dyad of both CO 2 and CS 2 have been measured. Upon dilution with CO 2 , the evolution of the spectroscopic observables of all these modes displays a "plateau-like" region in the CO 2 mole fraction 0.3-0.7 never previously observed in CO 2 -organic liquids mixtures. The bandshape and intensity of the induced modes of CS 2 are similar to those of pure CS 2 up to equimolar concentration, after which variations occur. The preservation of the local ordering from pure CS 2 to equimolar concentration together with the non-linear evolution of the spectroscopic observables allows inferring that two solvation regimes exist with a transition occurring in the plateau domain. In the first regime, corresponding to CS 2 concentrated mixtures, the liquid phase is segregated with dominant CS 2 clusters, whereas, in the second one, CO 2 monomers and dimers and CO 2 -CS 2 hetero-dimers coexist dynamically on a picosecond time-scale. It is demonstrated that the subtle interplay between attractive and repulsive interactions which provides a molecular interpretation of the non-ideality of the CO 2 -CS 2 mixture allows rationalizing the volume expansion and the existence of the plateau-like region observed in the pressure-composition diagram previously ascribed to the proximity of an upper critical solution temperature at lower temperatures.

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Section: Discussion On the Non-ideal Behaviour Of The Mixturementioning

confidence: 99%

Assessing the non-ideality of the CO2-CS2 system at molecular level: A Raman scattering study

Besnard

Cabaço²,

Coutinho

et al. 2013

The Journal of Chemical Physics

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“…A substantial amount of vapor-liquid equilibria and volumetric expansion data have been published for the CO 2 -solvent binary system. [12][13][14] The position of the operating point is in the supercritical region and is very far from the mixture critical point pressure in the vapor-liquid equilibria data for each solvent-CO 2 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Solvent Type on the Nanoparticle Formation of Atorvastatin Calcium by the Supercritical Antisolvent Process

et al. 2012

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The aims of this study were to identify how the solvent selection affects particle formation and to examine the effect of the initial drug solution concentration on mean particle size and particle size distribution in the supercritical antisolvent (SAS) process. Amorphous atorvastatin calcium was precipitated from seven different solvents using the SAS process. Particles with mean particle size ranging between 62.6 and 1493.7 nm were obtained by varying organic solvent type and solution concentration. By changing the solvent, we observed large variations in particle size and particle size distribution, accompanied by different particle morphologies. Particles obtained from acetone and tetrahydrofuran (THF) were compact and spherical fine particles, whereas those from N-methylpyrrolidone (NMP) and dimethylsulfoxide (DMSO) were agglomerated, with rough surfaces and relatively larger particle sizes. Interestingly, the mean particle size of atorvastatin calcium increased with an increase in the boiling point of the organic solvent used. Thus, for atorvastatin particle formation via the SAS process, particle size was determined mainly by evaporation of the organic solvent into the antisolvent phase. In addition, the mean particle size was increased with increasing drug solution concentration. In this study, from the aspects of particle size and solvent toxicity, acetone was the better organic solvent for controlling nanoparticle formation of atorvastatin calcium.Key words atorvastatin; nanoparticle; supercritical antisolvent; amorphous A new approach in particle engineering developed to obtain micro/nanoparticles with peculiar characteristics is represented by the supercritical fluid technology.1) Among the several types of supercritical fluid processes, supercritical antisolvent (SAS) process have some advantages such as easy handling of difficult-to-comminute materials, use of a nontoxic medium, and a mild operating temperature may provide ideal conditions for the processing of pharmaceutical compounds. Moreover, fast diffusion of supercritical antisolvent into the liquid solvent produces the supersaturation of the solute and its precipitation in micronized particles down to particle diameters, and control of the particle size distribution is also possible.2,3) Many researchers have been studied that the morphology, crystallinity, particle size and particle size distribution can be controlled through the changing of various process conditions such as temperature, pressure, solvent, drug solution concentration, solution to antisolvent flow rate ratio, and the rate of mass transfer in SAS process. [4][5][6][7][8][9] Previously, we investigated the effect of SAS process parameters such as the pressure, temperature, and feed rate ratio of CO 2 /drug solution on the particle formation of atorvastatin calcium using methanol as a solvent.10) In addition, we reported the usefulness of the amorphous nanoparticles as a method of enhancing the supersaturation, dissolution, and absorption properties of atorvastatin.11) However...

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“…However, little (P, T, y) data is available for the CO 2 -DMSO binary mixture. Only the data proposed by Kordikowski et al [9] is sufficiently complete. The authors have fitted to their data the Peng-Robinson equation of state (PR EoS) [10] with two quadratic mixing rules that include two temperature independent binary interaction parameters, k ij and l ij .…”

Section: Methodsmentioning

confidence: 99%

Solubility of eflucimibe in supercritical carbon dioxide with or without a co-solvent

Sauceau

Letourneau

Freiss

et al. 2004

The Journal of Supercritical Fluids

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Volume expansions and vapor-liquid equilibria of binary mixtures of a variety of polar solvents and certain near-critical solvents

Cited by 313 publications

References 4 publications

Assessing the non-ideality of the CO2-CS2 system at molecular level: A Raman scattering study

Assessing the non-ideality of the CO2-CS2 system at molecular level: A Raman scattering study

Effect of Solvent Type on the Nanoparticle Formation of Atorvastatin Calcium by the Supercritical Antisolvent Process

Solubility of eflucimibe in supercritical carbon dioxide with or without a co-solvent

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