Volume of intracranial structures on three‐dimensional ultrasound in fetuses with congenital heart disease

Zeng, Shi; Zhou, Qing; Zhou, Jiawei; Li, M.; Long, C. N. H.; Peng, Qinghai

doi:10.1002/uog.14677

Cited by 55 publications

(84 citation statements)

References 25 publications

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“…Examining the distal hemicerebrum only might seem insufficient, due to asymmetry in the brain; however, the fact that we randomly measured left and right hemispheres in cases and controls justifies this strategy. Our assessment of the brain volumes by VOCAL is slightly comparable to a study in 2015 by Zeng et al [39] studying complete intracranial volumes in 73 CHD cases, in which a smaller cerebral volume in CHD in the third trimester was found. However, Zeng et al [39] only included severe CHD with only a single measurement per case, did not report postnatal follow-up nor inter- and intraobserver variation analyses, and our VOCAL measurement rotation angle was more detailed (6- to 9-degree vs. 30-degree steps).…”

Section: Discussionsupporting

confidence: 70%

“…Our assessment of the brain volumes by VOCAL is slightly comparable to a study in 2015 by Zeng et al [39] studying complete intracranial volumes in 73 CHD cases, in which a smaller cerebral volume in CHD in the third trimester was found. However, Zeng et al [39] only included severe CHD with only a single measurement per case, did not report postnatal follow-up nor inter- and intraobserver variation analyses, and our VOCAL measurement rotation angle was more detailed (6- to 9-degree vs. 30-degree steps). Furthermore, in our experience, measuring the cerebral volume after GA 32 becomes less reliable with ultrasound because of extensive shadowing.…”

Section: Discussionsupporting

confidence: 70%

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Fetuses with Isolated Congenital Heart Defects Show Normal Cerebral and Extracerebral Fluid Volume Growth: A 3D Sonographic Study in the Second and Third Trimester

et al. 2019

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Objective: The aim of our study is to explore whether the cerebral growth is delayed in fetuses with congenital heart defects (CHD) in the second and early third trimester. Methods: A prospective cohort study was conducted in 77 CHD cases, with 75 healthy controls. 3D cerebral volume acquisition was performed sequentially. The volumes of the fetal hemicerebrum and extracerebral fluid were compared by linear regression analysis, and the Sylvian fissure was measured. Results: Between 19 and 32 weeks of gestation, 158 measurements in cases and 183 measurements in controls were performed (mean 2.2/subject). The volume growth of the hemicerebrum (R² = 0.95 vs. 0.95; p = 0.9) and the extracerebral fluid (R² = 0.84 vs. 0.82, p = 0.9) were similar. Fetuses with abnormal oxygen delivery to the brain have a slightly smaller brain at 20 weeks of gestation (p = 0.02), but this difference disappeared with advancing gestation. CHD cases demonstrated a slightly shallower Sylvian fissure (mean ratio 0.146 vs. 0.153; p = 0.004). Conclusions: Our study shows no differences in cerebral growth, studied in an unselected cohort, with successive cases of isolated CHD. Even in the severest CHD cases, cerebral size is similar in the early third trimester. The cause and meaning of a shallower Sylvian fissure is unclear; possibly, it is a marker for delayed cerebral maturation or it might be an expression of decreasing amount of extracerebral fluid.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 70%

Fetuses with Isolated Congenital Heart Defects Show Normal Cerebral and Extracerebral Fluid Volume Growth: A 3D Sonographic Study in the Second and Third Trimester

et al. 2019

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“…However, when the hypoxemia is severe, permanent cell death will become inevitable . Common abnormal findings in fetuses with CHD include increased cerebral blood flow, reduced brain fissures depth and brain volume, smaller head size, and structural brain abnormalities . Volumes of brain regions containing large numbers of neurons are most likely to be affected.…”

mentioning

confidence: 99%

Relationship Between Cavum Septi Pellucidi Measurements and Fetal Hypoplastic Left Heart Syndrome or Dextro‐Transposition of the Great Arteries

Saadeh

Zhao

Galadima

et al. 2017

J of Ultrasound Medicine

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“…In a previous study, Limperopoulos et al [11] reported that some types of CHD were independently associated with more pronounced changes in MRI brain total volume. More recently, Zeng et al reported that HLHS and TGA were associated with more pronounced changes in total intracranial volume, frontal lobe volume and cerebellar volume [20]. …”

Section: Introductionmentioning

confidence: 99%

Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply

et al. 2015

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Objectives: We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. Methods: A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD). Head biometry and cerebroplacental Doppler were assessed by ultrasound, and brain volumetry, cortical development and metabolism by MRI. Results: Both class A and B CHD fetuses had significant differences in head biometry, brain perfusion, cortical development and brain metabolism compared with controls. However, there was a significant linear tendency for head biometry, cerebral Doppler, volumes, cortical sulcation and metabolic ratios across the three clinical groups, with signs of more severe brain alterations in type A CHD fetuses. Conclusions: All fetuses with CHD showed significant brain developmental changes, but differences were more pronounced in CHD associated with an expected severe reduction in oxygenated blood supply to the brain.

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Volume of intracranial structures on three‐dimensional ultrasound in fetuses with congenital heart disease

Abstract: Objective To investigate the volume of intracranial structures in fetuses with congenital heart disease (CHD). Methods

Cited by 55 publications

References 25 publications

Fetuses with Isolated Congenital Heart Defects Show Normal Cerebral and Extracerebral Fluid Volume Growth: A 3D Sonographic Study in the Second and Third Trimester

Fetuses with Isolated Congenital Heart Defects Show Normal Cerebral and Extracerebral Fluid Volume Growth: A 3D Sonographic Study in the Second and Third Trimester

Relationship Between Cavum Septi Pellucidi Measurements and Fetal Hypoplastic Left Heart Syndrome or Dextro‐Transposition of the Great Arteries

Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply

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