Volume Regulation and Renal Function in Analbuminæmia

Blood Volume and Sodium Retention in the Nephrotic Syndrome: A Controversial Pathophysiological Concept

“…This was suggested repeatedly by early investigators [32, 71.75] but later discarded because of the lack of corre lation between GFR and sodium excretion. However, as stressed recently by Bennett [10], the same problem pre sents itself in the analysis of edema formation during acute glomerulonephritis. In rats with various forms of experi mental glomerulonephritis a decrease in Kf is accom panied by an increase in RPF and perfusion pressure.…”

“…In rats with various forms of experi mental glomerulonephritis a decrease in Kf is accom panied by an increase in RPF and perfusion pressure. The adaptive mechanism causing the GFR to remain constant was shown to be related to expansion of the ECF [10].…”

Comparative Studies on the Half-Life of I131-Labeled Albumins and Nonradioactive Human Serum Albumin in a Case of Analbuminemia

“…The rate of disappearance of the former was obtained by measuring the decay of radioactivity in the usual manner and of the latter by means of paper electrophoresis and immunological tests. METHODS (1)(2)(3)(4)(5). On June 10,1953,50 Gm.…”

“…Brief summary of the clinical condition (1)(2)(3)(4)(5) The female analbuminemic subject, a peasant's daughter who was born in 1922, came into the clinic with edema in her ankles. She was sent by her physician for investigation of a high blood sedimentation rate (between 42/68 and 95/104 mm.…”

“…The exact data are contained in earlier papers (1-4, 10-13), or will be published in due course (5). RESULTS …”