Volumen plaquetario medio como predictor de mortalidad en pacientes con sepsis y choque séptico en urgencias

Estrada-Escobar, Ricardo Andrés; Santillán-Santos, Diego Armando; Merinos-Sánchez, Graciela

doi:10.24875/reie.19000008

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Several studies have demonstrated the predictive utility of MPV in sepsis [ 4 , 11 – 16 ], Vardon-Bounes F, et al [ 17 ], reported MPV as a predictor of mortality (HR = 3,79) at 90-day survival study. Additionally, a meta-analysis performed by Tajarernmuang P. et al [ 18 ], reported 11 studies (n = 3724), in which a significant association was determined between the MPV and mortality in critically ill patients on day 3.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

Páez

Légua

Páez³

et al. 2022

PLoS ONE

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Introduction Sepsis is a public health problem due to its high prevalence and mortality. Mean platelet volume (MPV), a biomarker reported in routine blood counts, has been investigated and shows promise for determining fatal outcomes in septic patients. Objective Evaluate whether the mean platelet volume (MPV) and mean platelet volume-to-platelet count (MPV/P) ratio are predictors of clinical severity and mortality in patients with sepsis. Methods A prospective population cohort of 163 patients aged 18–97 years was recruited at the Intensive Care Unit of Pablo Arturo Hospital, Quito, Ecuador from 2017–2019 and followed up for 28 days. Patients were diagnosed with sepsis based on SEPSIS-3 septic shock criteria; in which the MPV and the MPV/P ratio were measured on days 1, 2, and 3. Sequential organ failure assessment (SOFA) score and presence of septic shock assessed clinical severity. Mortality on day 28 was considered the fatal outcome. Results The average age of the patients was 61,15 years (SD 20,94) and female sex was predominant. MPV cutoff points at days 1, 2 and 3 were >9,45fL, >8,95fL and >8, 85fL; and (MPV/P) ratio >8, 18, >4, 12 y >3, 95, respectively. MPV at days 2 (9,85fL) and 3 (8,55fL) and (MPV/P) ratio at days 1 (4,42), 2 (4,21), and 3 (8,55), were predictors of clinical severity assessed by septic shock, which reached significance in the ROC curves. MPV and (MPV/P) ratio were also predictors of clinical severity determined by SOFA at days 1, 2, and 3, where higher values were observed in non-survivors reaching significance in all categories. MPV and MPV/P ratio at days 1, 2 and 3 were independent predictor factors of mortality using Cox proportional hazards model (HR 2,31; 95% CI 1,36–3,94), (HR 2,11; 95% CI 1,17–3,82), (HR 2,13; 95% CI 1,07–4,21) and (HR 2,38; 95% CI 1,38–4,12), (HR 2,15; 95% CI 1,14–4,06), (HR 4,43; 95% CI, 1,72–11,37) respectively. Conclusions MPV and the MPV/P ratio are predictors of clinical severity and mortality in sepsis. The MPV and its coefficient are indicators of the biological behavior of platelets in sepsis. They should be considered as a cost-effective and rapidly available tool that guides the treatment.

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Section: Discussionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

Páez

Légua

Páez³

et al. 2022

PLoS ONE

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Mean platelet volume and its close relationship with septic hospital infections

Freire

Paredes

2023

Salud, Ciencia y Tecnología

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Introduction: the average platelet volume is obtained from the blood count, considered as a low-cost and easily accessible biomarker, available in all medical units. It is considered a biomarker that indicates inflammation, thrombosis, and endothelial injury, while foreign studies have shown encouraging advances in diseases with prothrombotic and immunoinflammatory components. Objective: to establish the relationship of mean platelet volume with hospital septic infections. Methodology: information sources available in the Pubmed, Medicgraphic, and SciELO databases were consulted, as well as the Google Scholar search engine. Publications in both English and Spanish were included, with a maximum of 5 years prior to the topic of interest. Results: original articles were analyzed in which populations of neonates and adults with sepsis are analyzed. Populations of newborns reflected a high value of MPV in the first 24 hours, proving to be an early predictive marker in the diagnosis of neonatal sepsis, while population studies in adults reflected a much higher MPV in septic patients who later died. in relation to those who survived, being also considered a predictor of mortality. Conclusions: it is evident that MPV is closely related to sepsis since it increases progressively during infection, constituting a biomarker for early prediction and poor prognosis in sepsis.

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Volumen plaquetario medio como predictor de mortalidad en pacientes con sepsis y choque séptico en urgencias

Cited by 2 publications

References 14 publications

Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

Mean platelet volume and its close relationship with septic hospital infections

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