Volumetric, acoustic and viscometric studies of L-histidine and L-serine in aqueous levofloxacin solutions at different temperatures and concentrations

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

“…Due to augmentation in drug–maline interactions, K ϕ,s values advance with maline concentrations and temperature. Furthermore, the negative sign of K ϕ,s values reveals that the H 2 O present in bulk solution is highly compressible than that surrounding the drug molecules, which in turn demonstrates the existence of effective drug–maline interactions in the prepared systems. , …”

“…Furthermore, the negative sign of K ϕ,s values reveals that the H 2 O present in bulk solution is highly compressible than that surrounding the drug molecules, which in turn demonstrates the existence of effective drug−maline interactions in the prepared systems. 38,39 The probable uncertainties in apparent molar isentropic compression δK ϕ,s 40 were anticipated via the relation shown below…”

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

“…It is well known that Jones–Dole coefficient B , that is, viscosity B -coefficient, is also a very important thermodynamic parameter characterizing the intermolecular interactions between a drug and solvent molecules . The viscosity B -coefficients of the drug FA in the aqueous ethanol/1-propanol solutions were calculated from our viscosity measurements using the Jones–Dole equation: , η normalr = η / η 0 = 1 + A c 1 / 2 + B c where η r is the relative viscosity of the FA solution; η and η 0 are the viscosities of the solution and the solvent (aqueous ethanol/1-propanol), respectively; c is the concentration of FA in the solution obtained from the molality; and A and B are the Falkenhagen coefficient and viscosity B -coefficient, respectively. The A -coefficient represents the solute–solute interactions, while the B -coefficient reflects the solute–solvent interactions.…”

“…It is well known that Jones−Dole coefficient B, that is, viscosity B-coefficient, is also a very important thermodynamic parameter characterizing the intermolecular interactions between a drug and solvent molecules. 65 The viscosity B-coefficients of the drug FA in the aqueous ethanol/1-propanol solutions were calculated from our viscosity measurements using the Jones−Dole equation: 73,74 As can be seen, the slope of linear regression of η r − c dependence directly gives us the values of B-coefficients (Table 5).…”

Volumetric, Viscometric, and Refractive Index Studies of Drug Nicotinic Acid in Aqueous d-Xylose/l-Arabinose Solutions from 293.15 to 313.15 K: Insights into Solute–Solute and Solute–Solvent Interactions

“…Volumetric analysis is a crucial method of elucidating the physicochemical phenomena of solutes in solution. − Moreover, the viscosity and refractive index of the mixed solution are two other important parameters that can provide valuable information for a better understanding of intermolecular interactions. − It is well known that most biochemical processes occur in aqueous media. Therefore, research on the volumetric properties, viscometric properties, and refractive indices of drugs in aqueous media is helpful for deepening the understanding of drug molecular interactions, which contributes significantly to advancements in the fields of pharmacy and pharmaceutical chemistry. − However, the drug–solvent interactions that can elucidate the solvation behavior of drugs in vivo are difficult to investigate directly because of the presence of various cosolutes, such as carbohydrates, amino acids, salts, proteins, and so forth in biosystems.…”