Volumetric and acoustic methods for investigating molecular interactions of antibiotic drug doxycycline hyclate in water and in aqueous solution of sodium chloride and potassium chloride at different temperatures (293.15–313.15) K

Lomesh, Shashi Kant; Nathan, Vikas; Bala, Madhu; Thakur, Poonam

doi:10.1016/j.molliq.2019.04.006

Cited by 33 publications

(5 citation statements)

References 54 publications

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“…Also, this flattening of V φ curves (values) becomes more and more close to the origin, i.e., at lower concentration of NaC/NaDC, with the addition of drug that signifies the strengthening of micellization in the presence of Cft-Na. This reveal that at lower concentration, ionic and hydrophilic–hydrophilic interactions play their role, while at higher concentrations, these interactions are dominated by hydrophobic–hydrophobic interactions . The curvilinear nature of the variation in V φ has also been supported in earlier reports on bile salts ,, as well as for the conventional surfactant. , From V φ values, it can also be observed that the temperature and content of Cft-Na increases V φ values, signifying the manifestation of solute–solvent interactions with addition of drug, which enhances with temperature due to destructive overlap .…”

Section: Resultssupporting

confidence: 68%

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

Singh

Chauhan

2020

J. Chem. Eng. Data

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Interactional behavior of bile salts, namely, sodium cholate (NaC) and sodium deoxycholate (NaDC), in the presence of an antibiotic drug, ceftriaxone sodium (Cft-Na), at different temperatures has been analyzed through volumetric, compressibility, viscometric, and proton nuclear magnetic resonance ( 1 H-NMR) studies. The volumetric and compressibility parameters have been calculated with the help of measured density (ρ) and speed of sound (u). Also, the knowledge on intermolecular interactions present in a ternary system consisting of bile salts in aqueous solution of drug has been procured from viscometric measurements. The variation in strength of the present intermolecular interactions in the system with temperature and concentration has been analyzed by carrying out the experiments at different temperatures, i.e., 293.15, 298.15, 303.15, 308.15, and 313.15 K, and drug concentrations, i.e., 0.005, 0.010, and 0.050 mol•kg −1 . The results have been interpreted by considering the cosphere overlap model, which confirm the presence of hydrophobic and hydrophilic interactions in the system. Also, the information obtained from density, speed of sound, and viscometric studies has been strengthened by analyzing the 1 H-NMR spectra. The study may be helpful in utilization of bile salts in pharmaceutical industries as a penetration enhancer.

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Section: Resultssupporting

confidence: 68%

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

Singh

Chauhan

2020

J. Chem. Eng. Data

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“…and slopes S V calculated using Masson equation ( 2) are reported in Table 3. The ∅ V 0 values of KClO 3 , KBrO 3 and KIO 3 under investigation in KCl are large and positive suggests presence of strong solutesolvent interactions promotes structure making effect 23 .…”

Section: Resultsmentioning

confidence: 91%

Comparative Study of Solvation Behaviour of Oxidising Agents Like Kclo3, Kbro3 and KIO3 in Aqueous Solvent Systems at Different Temperatures

Rathi¹

2021

Orient. J. Chem

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The investigation of the solvationtrend of oxidizing agents like KClO3, KBrO3 and KIO3as electrolytes in aqueous salt solution rendersthe datasuited to interpret ion–ion, solute–solvent, ion-solvent and solvent–solvent interactions and synergy. Apparent molar volumes (∅_V) and viscosity B-coefficients for KClO3, KBrO3 and KIO3solutions in aqueous 0.5 % KCl ,system have been calculated from density (ρ) and viscosity (η) measurements at 298.15 to 313.15 K using a calibrated bicapillary pycnometer and the simple, yet accurate apparatus known as Ubbelohde viscometer respectively. Jones-Dole equation,Masson’s equation, Roots equation and Moulik’s equations are implemented to analyse various interactions inter and intra ionic attractions among the ion–ion, ion–solvent, and solute–solvent. Additionallythe apparent molar volumes of transfer Δ ∅(tr) and Rate constant diffusion controlled reaction (kd)are valuated.

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“…The calculated values of L f for aqueous sugar alcohol and l -arginine solutions in water show that by rising concentrations of solute, cosolute, and temperature, the L f values decline, which indicate the strong molecular interactions such as solute–solute and solute–solvent molecules. This decreasing trend of L f with concentration and temperature makes the structure compact . A decreasing trend in L f values also indicates the close stuffing of molecules and structure-making behavior …”

Section: Resultsmentioning

confidence: 99%

“…This decreasing trend of L f with concentration and temperature makes the structure compact. 43 A decreasing trend in L f values also indicates the close stuffing of molecules and structuremaking behavior. 1…”

Section: Intermolecular Freementioning

confidence: 99%

Investigations to Explore Molecular Interactions and Sweetness Response of Polyhydroxy Compounds with Amino Acids in Aqueous Systems

et al. 2022

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In conjunction with the development of people's living standards, the modern world demands good-quality food such as sweets, candies, chocolates, diet drinks, beverages, and so on, but because of obesity and other health issues people concentrate more on sugar-free or low-calorie products. Polyols are such a kind of food with desirable qualities, and they play a role in controlling the blood glucose level in diabetic patients. The density (ρ) and sound speed (u) of sugar alcohol in water and in (0.02, 0.04, and 0.06) mol kg −1 L-arginine solutions at different temperatures (293.15−318.15 K) and atmospheric pressure were measured by using Anton Paar DSA5000M. Experimental density and sound velocity data were further used to compute volumetric and acoustic parameters such as apparent molar volume (Ø V ), partial molar volume (Ø V 0 ), compressibility (Ø k 0), expansibility (Ø E 0 ), and so on. The positive trends of apparent molar volume (Ø V ), and partial molar volume Ø V 0 ), values indicate strong hydrophilic interactions in ternary solutions. These interactions give a complete picture about solvation behavior, the effect of temperature, and hydrogen bonding present among (galactitol + L-arginine) mixtures. The apparent specific volume values were calculated, and it was found that these values of the investigated mixtures lie on the borderline with the reported values of sweeteners. This study may offer a new vision in elucidation of mechanistic modifications between sugar alcohol, amino acid, and their mode of interactions.

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Volumetric and acoustic methods for investigating molecular interactions of antibiotic drug doxycycline hyclate in water and in aqueous solution of sodium chloride and potassium chloride at different temperatures (293.15–313.15) K

Cited by 33 publications

References 54 publications

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

Interactional Behavior of Sodium Cholate and Sodium Deoxycholate in the Presence of Ceftriaxone Sodium: Volumetric, Compressibility, Viscometric, and Proton Nuclear Magnetic Resonance Studies

Comparative Study of Solvation Behaviour of Oxidising Agents Like Kclo3, Kbro3 and KIO3 in Aqueous Solvent Systems at Different Temperatures

Investigations to Explore Molecular Interactions and Sweetness Response of Polyhydroxy Compounds with Amino Acids in Aqueous Systems

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