Volumetric and acoustic studies of amino acids in aqueous ionic liquid solution

Gaba, Rekha; Pal, Amalendu; Kumar, Harsh; Sharma, Dinkar; Navjot,

doi:10.1016/j.molliq.2017.07.058

Cited by 13 publications

(2 citation statements)

References 56 publications

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“…However, volumetric and transport properties of L-serine and L-threonine in binary and ternary aqueous solutions of other ILs were determined in several works [14][15][16][17][18][19][20][21]. We found that, the studied ionic liquid promoted remarkable changes in the solubility of the studied amino acid by reducing the pH of the solution [12].…”

Section: Introductionmentioning

confidence: 96%

Study of Thermodynamic Properties of L-serine and L-threonine in Aqueous Solutions of 1- (2-carboxyethyl)-3-methylimidazolium chloride [HOOCEMIM][Cl]

Asadzadeh

Majdan-Cegincara

Zafarani-Moattar

2022

Preprint

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The stability of amino acids in solutions containing electrolytes and the effect of ambient pH on their biological activity is one of the new research areas. In this research work, the volumetric and transport properties of ionic liquid (IL) aqueous solution with special performance of 1- (2-carboxyethyl) -3-methylimidazolium chloride ([HOOCEMIM][Cl]) were studied. The selected IL acts as an electrolyte with minimal toxicity and also allows the study of systems containing amino acids at acidic pH. In this work, the density, speed of sound and viscosity of binary and ternary solutions of IL in aqueous solution of amino acids in the structure of proteins, namely L-serine and L-threonine within IL molality range of (0.05, 0.07 and 0.09 mol kg-1) were measured at 298.15 K. From these quantities, apparent molar volume, limiting apparent molar volume, apparent molar isentropic compression, limiting apparent molar isentropic compression, transfer standard volumes for amino acids from water to the aqueous IL solutions and viscosity B-coefficients were calculated using the equations of Redlich–Meyer and Jones–Dole. Close examination of literature indicates that there is no data for water activity for solution of L-serine + H2O at 308.15 and 318.15 K. In this way water activity, osmotic coefficient and vapor pressure were measured and using the interaction parameters of Wilson, NRTL, NRF-NRTL and UNIQUAC models, activity coefficient values of L-serine calculated.

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Section: Introductionmentioning

confidence: 96%

Study of Thermodynamic Properties of L-serine and L-threonine in Aqueous Solutions of 1- (2-carboxyethyl)-3-methylimidazolium chloride [HOOCEMIM][Cl]

Asadzadeh

Majdan-Cegincara

Zafarani-Moattar

2022

Preprint

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“…Importantly, volumetric analysis of aqueous L-amino acid in the presence of 1-ethyl-3-methylimidazolium bromide demonstrated that the hydrophilic side chain of an AA interacts strongly with the IL as compared to an hydrophobic AA . Gaba et al ,, extensively studied the solvation properties of different AA in the presence of ILs to explore the interaction behavior of ILs with the AAs.…”

Section: Introductionmentioning

confidence: 99%

Impact of an Ionic Liquid on Amino Acid Side Chains: A Perspective from Molecular Simulation Studies

Ghanta

Mondal

Hajari³

et al. 2023

J. Chem. Inf. Model.

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Ionic liquids (ILs) are known to modify the structural stability of proteins. The modification of the protein conformation is associated with the accumulation of ILs around the amino acid (AA) side chains and the nature of interactions between them. To understand the microscopic picture of the structural arrangements of ILs around the AA side chains, room temperature molecular dynamics (MD) simulations have been carried out in this work with a series of hydrophobic, polar and charged AAs in aqueous solutions containing the IL 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]) at 2 M concentration. The calculations revealed distinctly nonuniform distribution of the IL components around different AAs. In particular, it is demonstrated that the BMIM + cations preferentially interact with the aromatic AAs through favorable stacking interactions between the cation imidazolium head groups and the aromatic AA side chains. This results in preferential parallel alignments and enhanced population of the cations around the aromatic AAs. The potential of mean force (PMF) calculations revealed that such favorable stacking interactions provide greater stability to the contact pairs (CPs) formed between the aromatic AAs and the IL cations as compared to the other AAs. It is further quantified that for most of the AAs (except the cationic ones), a favorable enthalpy contribution more than compensates for the entropy cost to form stable CPs with the IL cations. These findings are likely to provide valuable fundamental information toward understanding the effects of ILs on protein conformational stability.

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Study of Thermodynamic Properties of l-Serine and l-Threonine in Aqueous Solutions of 1-(2-Carboxyethyl)-3-methylimidazolium Chloride [HOOCEMIM][Cl]

2023

View full text Add to dashboard Cite

The stability of amino acids in solutions containing electrolytes and the effect of ambient pH on their biological activity is an important research area. In this research work, the volumetric and transport properties of ionic liquid (IL) aqueous solution with special performance of 1-(2-carboxyethyl)-3-methylimidazolium chloride ([HOOCEMIM][Cl]) were studied. The selected IL acts as an electrolyte and allows the study of systems containing amino acids at acidic pH. In this work, the density, speed of sound and viscosity of binary and ternary solutions of IL in aqueous solution of amino acids in the structure of proteins, namely l-serine and l-threonine within IL molality range of (0.05, 0.07 and 0.09 mol·kg−1) were measured at 298.15 K. From these quantities, apparent molar volume, limiting apparent molar volume, apparent molar isentropic compression, limiting apparent molar isentropic compression, transfer standard volumes for amino acids from water to the aqueous IL solutions and viscosity B-coefficients were calculated using the equations of Redlich–Meyer and Jones–Dole. Close examination of literature indicates that there is no data for water activity for solution of l-serine + H2O at 308.15 and 318.15 K. In this way water activity, osmotic coefficient and vapor pressure were measured and using the interaction parameters of Wilson, NRTL, NRF-NRTL and UNIQUAC models, activity coefficient values of l-serine calculated.

show abstract

Volumetric and acoustic studies of amino acids in aqueous ionic liquid solution

Cited by 13 publications

References 56 publications

Study of Thermodynamic Properties of L-serine and L-threonine in Aqueous Solutions of 1- (2-carboxyethyl)-3-methylimidazolium chloride [HOOCEMIM][Cl]

Study of Thermodynamic Properties of L-serine and L-threonine in Aqueous Solutions of 1- (2-carboxyethyl)-3-methylimidazolium chloride [HOOCEMIM][Cl]

Impact of an Ionic Liquid on Amino Acid Side Chains: A Perspective from Molecular Simulation Studies

Study of Thermodynamic Properties of l-Serine and l-Threonine in Aqueous Solutions of 1-(2-Carboxyethyl)-3-methylimidazolium Chloride [HOOCEMIM][Cl]

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