Volumetric and calorimetric properties of aqueous ionene solutions

Lukšič, Miha; Hribar-Lee, Barbara

doi:10.1016/j.molliq.2016.09.043

Cited by 2 publications

(3 citation statements)

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“…The hydrohobic characteristic of the backone of these ionenes has been recently established by volumetric and calorimetric measurements. 27…”

Section: Resultsmentioning

confidence: 99%

“…In the past, several studies of thermodynamic, as well as dynamic properties of aqueous ionene solutions were carried out, and the results are summarized in some more recent papers. 18,27–29 The properties of the ionenes that proved to be crucial for their behavior are the linear charge density of the polyion, characterized by the parameter ξ=e02/(4πε0εb) ( e 0 is the elementary charge, ε 0 and ε are the permittivities of vacuum and of solvent, respectively, and b denotes the average length in-between two charged groups of the polyion), and the nature of the counterions. Counterions are known to, depending on their characateristics, condense on the polyions to a different extent, and in this way modify the charge density of the polyelectrolyte, and consequently also the mobility of the polycations.…”

Section: Introductionmentioning

confidence: 99%

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DNA–Polyelectrolyte Complexation Study: The Effect of Polyion Charge Density and Chemical Nature of the Counterions

2018

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Complexes of polycations and DNA, also known as polyplexes, have been extensively studied in the past decade, as potential gene delivery systems. Their stability depends strongly on the characteristics of the polycations, as well as the nature of the added salt. We present here a study of the DNA ionene complexation in which we used fluorescence, UV, and CD spectroscopy, combined with molecular dynamics computer simuations, to systematically examine the influence of the polycation charge density, as well as the influence of the nature of the counterion, on the stability of these systems. Ionenes as polycations, depending on their structural characteristics, have previously been found to possess low cytotoxicity, and are therefore particularly interesting as potential gene delivery agents. The results show that the DNA solutions in the presence of the polycation are more stable in the case of very large or very small ionene charge density, suggesting different mechanism of complexation. The computer simulations show that the ionenes with high charge density bind to the minor groove of the DNA molecules, while the ionenes with lower charge density bind to the major groove of the DNA. The nature of the counterions play only a minor role: precipitation of the DNA molecules occurs at slightly lower ionene concentration when fluoride counterion are present, compared to the bromide counterions.

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“…The hydrohobic characteristic of the backone of these ionenes has been recently established by volumetric and calorimetric measurements. 27…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

DNA–Polyelectrolyte Complexation Study: The Effect of Polyion Charge Density and Chemical Nature of the Counterions

2018

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“…Examples would make the matter clear. If the study of partial molar volumes [10][11][12][13][14] of solutes under infinite dilution facilitates the understanding of solute-solvent and solvent-solvent interactions, then the solute-solute interactions can be studied using concentration dependence of apparent molar volume [14][15][16][17] of solute. The present investigation is geared towards the understanding of polyion-counterion interactions as well as the solvation behavior of the counterions using the apparent and partial molar volumes of Sodium Carboxymethylcellulose (NaCMC) in acetonitrile-water mixtures.…”

Section: Introductionmentioning

confidence: 99%

The Apparent and Partial Molar Volumes of Sodium Carboxymethylcellulose in Acetonitrile-Water Mixed Solvent Media

Nandi¹,

Das²

2019

RJC

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The volumetric properties of Sodium Carboxymethylcellulose (NaCMC) in acetonitrile-water mixed solvent media containing (0.10, 0.20, and 0.40) volume fractions of acetonitrile were studied by measuring the density of solutions at temperatures (298.15, 308.15, 313.15, and 318.15) K. Besides studying the solvation behavior of the counterions, the study was focused on investigating the interactions between the counterion and the polyion. In the specified temperature range, a linear increase for apparent molar volume ( v φ ) with increasing polyelectrolyte concentration was observed in a medium with fixed volume fractions of acetonitrile. However, at a given temperature as the medium became richer in acetonitrile the limiting partial molar volumes ( 0 2 − V ) registered a decrease. But, when a polyelectrolyte solution in a fixed medium underwent a step-wise increase in temperature then 0 2 − V values increased thereby leading to the inference that a temperature-induced desolvation of the counterions results in more counterion binding at higher temperatures.

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Volumetric and calorimetric properties of aqueous ionene solutions

Cited by 2 publications

References 47 publications

DNA–Polyelectrolyte Complexation Study: The Effect of Polyion Charge Density and Chemical Nature of the Counterions

DNA–Polyelectrolyte Complexation Study: The Effect of Polyion Charge Density and Chemical Nature of the Counterions

The Apparent and Partial Molar Volumes of Sodium Carboxymethylcellulose in Acetonitrile-Water Mixed Solvent Media

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