Volumetric and visual assessment of the mesial temporal structures in Alzheimer's disease

Desmond, Patricia; O’Brien, John T.; Tress, Brian M.; Ames, David; Clément, Jean‐Pierre; Clement, Pamelia F.; Schweitzer, Isaac; Tuckwell, Virginia; Robinson, G. A.

doi:10.1111/j.1445-5994.1994.tb01756.x

Cited by 33 publications

(17 citation statements)

References 14 publications

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“…Atrophy affecting temporal structures is virtually universal in AD with both CT and on MRI (Jack et al, 1992;Desmond et al, 1994;Laakso et al, 1995;Heun et al, 1997). Fewer studies have examined temporal lobe structures in depression and the diagnostic groups are more heterogeneous than in the AD populations.…”

Section: Temporal Lobe Structuresmentioning

confidence: 98%

Is late onset depression a prodrome to dementia?

Schweitzer

Tuckwell

O’Brien

et al. 2002

Int J Geriat Psychiatry

140

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Section: Temporal Lobe Structuresmentioning

confidence: 98%

Is late onset depression a prodrome to dementia?

Schweitzer

Tuckwell

O’Brien

et al. 2002

Int J Geriat Psychiatry

140

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show abstract

“…As such, every third coronal slice throughout the length of the hippocampus was displayed simultaneously on a 21 inch monitor in a manner resembling a typical radiological film with 12 images. In keeping with other visual assessment methods in the literature, 14 Periventricular hyperintensities and white matter abnormalities were rated by the same radiologist (LJR) using a technique that has been described in detail elsewhere. 15 16 Briefly, the number and size of the lesions were rated using existing semiquantitative scales.…”

Section: Mri Image Processingmentioning

confidence: 99%

Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study

Lye

Piguet

Grayson

et al. 2004

Journal of Neurology, Neurosurgery & Psychiatry

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Objectives: The purpose of this study was to define magnetic resonance imaging (MRI) correlates of normal brain ageing, with the specific objective of investigating whether the size of the hippocampus is selectively correlated with age related memory performance in non-demented individuals in their ninth and tenth decades of life. Methods: Hippocampal size was estimated using MRI based volumetry and qualitative visual assessment in 102 community dwelling individuals aged between 81 and 94 years. Participants were evaluated on a variety of clinical and experimental instruments, including a comprehensive neuropsychological test battery. All participants underwent neurological examination, an extensive medical history was obtained, and an informant confirmed details of each participant's functional ability. Results: Both visual and volumetric hippocampal measures were identified as robust predictors of memory performance, even when the influence of age related illnesses and sociodemographic variables was accounted for. When the sample was reduced to include the most cognitively healthy participants who were rated by an informant as showing no evidence of cognitive decline, the left hippocampal measures remained significant predictors of delayed retention of verbal material. Conclusions: These findings suggest that hippocampal volumes are selectively correlated with memory functioning in both normal and successful ageing.

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“…Visual assessment (common clinical practice) of atrophy of temporal structures approaches comparable reliability as volumetric techniques (a common research technique) at correctly identifying Alzheimer's patients from control subjects. 3,4 In addition, ventricular enlargement of the brain demonstrated by both linear and volumetric assessment has been correlated with memory decline in Alzheimer's Disease, and linear assessment can be substituted for the more laborious volume measurements. 5 However, the ability of standard visual brain MRI examination to detect tissue damage in regions which control depression and executive function in HF is unclear.…”

Section: Introductionmentioning

confidence: 99%

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

Pan

Kumar

Macey

et al. 2013

Journal of Cardiac Failure

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Background Heart failure (HF) patients exhibit depressive and executive function impairments that contribute to HF mortality. Using specialized magnetic resonance imaging (MRI) analysis procedures, brain changes appear in areas regulating these functions (mammillary bodies, hippocampi, and frontal cortex). However, specialized MRI procedures are not part of standard clinical assessment for HF (which is usually a visual evaluation), and it is unclear whether visual examination can detect changes in these structures. Methods and Results Using brain MRI, we visually examined the mammillary bodies and frontal cortex for global and hippocampi for global and regional tissue changes in 17 HF and 50 control subjects. Significant global changes emerged in the right mammillary body (HF vs. control scores; 1.18±1.13 vs. 0.52±0.74; P=.024), right hippocampus (1.53±0.94 vs. 0.80±0.86; P=0.005), and left frontal cortex (1.76±1.03 vs. 1.24±0.77; P=0.034) between groups. Comparison of the visual method with specialized MRI techniques corroborates right hippocampal and left frontal cortical, but not mammillary body, atrophy. Conclusions Visual examination of brain MRI can detect damage in HF in areas regulating depression and executive function, including the right hippocampus and left frontal cortex. Visual MRI assessment may facilitate evaluation of injury to these structures and the assessment of the impact of potential treatments for this damage.

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Volumetric and visual assessment of the mesial temporal structures in Alzheimer's disease

Abstract: Volumetric and visual assessment of the mesial temporal structures is useful in separating Alzheimer patients from controls. Overlap is present in individual cases. Visual assessment was as useful in separating the two groups as the volumetric analysis.

Cited by 33 publications

References 14 publications

Is late onset depression a prodrome to dementia?

Is late onset depression a prodrome to dementia?

Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

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