Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System

Lin, Zi Jing; Niu, Haijing; Lin, Li; Liu, Hanli

doi:10.1155/2012/276367

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…HD-DOT was shown to approach the resolution and accuracy of BOLD-fMRI in the adult brain. 31 However, HD-DOT measures the change in concentration of oxy-and deoxy-hemoglobin during functional activation in small animals and humans 15,30,32 without retrieving CBF information. In HD-DOT, CBF information can be inferred by the use of specific challenges or contrast agents, thus making the measurements complex.…”

Section: Introductionmentioning

confidence: 99%

High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain

et al. 2019

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Noninvasive, three-dimensional, and longitudinal imaging of cerebral blood flow (CBF) in small animal models and ultimately in humans has implications for fundamental research and clinical applications. It enables the study of phenomena such as brain development and learning and the effects of pathologies, with a clear vision for translation to humans. Speckle contrast optical tomography (SCOT) is an emerging optical method that aims to achieve this goal by directly measuring three-dimensional blood flow maps in deep tissue with a relatively inexpensive and simple system. High-density SCOT is developed to follow CBF changes in response to somatosensory cortex stimulation. Measurements are carried out through the intact skull on the rat brain. SCOT is able to follow individual trials in each brain hemisphere, where signal averaging resulted in comparable, cortical images to those of functional magnetic resonance images in spatial extent, location, and depth. Sham stimuli are utilized to demonstrate that the observed response is indeed due to local changes in the brain induced by forepaw stimulation. In developing and demonstrating the method, algorithms and analysis methods are developed. The results pave the way for longitudinal, nondestructive imaging in preclinical rodent models that can readily be translated to the human brain.

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Section: Introductionmentioning

confidence: 99%

High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain

et al. 2019

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“…Then the "Γ (ξ, s, μ)" data at the detection sites are calculated with the finite element method at different conditions. Finally, images are reconstructed and the quality of the reconstructed images is compared using the following parameters [17,43,44].…”

Section: Evaluation With Simulated Datamentioning

confidence: 99%

An endoscopic diffuse optical tomographic method based on the effective detection range

Qin

Cui

Zhao

et al. 2013

Journal of X-Ray Science and Technology

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Endoscopic diffuse optical tomography (DOT) is a new medical imaging modality with the potential applications in functional imaging of the internal organs. To cut down the measurement time and the computation burden of image reconstruction, in this paper, we developed the image reconstruction algorithm with the partial measurement in the effective detection range (EDR) of a tubular tissue and the corresponding endoscopic imaging system with a novel endoscopic probe for flexibly selecting the detection sites. For a typical inner size and optical properties of the cervix, it is found that EDR is less than half of the inner circumference. Comparing to the traditional method, the adoption of EDR results in a reduction of more than a factor of two in the time cost for a measurement cycle and for the total iteration reconstruction. Images reconstructed from the simulation data demonstrate that the proposed method achieves equivalent image quality to that obtained from the complete data set. The images reconstructed from the EDR measurements on cervix-like solid phantoms show that both the location and size of the targets are reconstructed correctly. The proposed method will be useful to the development of endoscopic DOT technologies for cancer detection in tubular organs including cervix.

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“…[ 8 ] In many studies, the uniformity of the sensitivity matrix was used to evaluate different geometries. [ 9 10 11 12 ] The sensitivity matrix is derived from the sum of the Jacobian matrix rows and represents the sensitivity of the sample points for all of the source-detector pairs. The sensitivity matrix is the function of the imaging geometry and sampling strategy.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity laplacian ratio-based optimization of the projection selection for diffuse optical tomography

2020

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Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System

Cited by 9 publications

References 27 publications

High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain

High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain

An endoscopic diffuse optical tomographic method based on the effective detection range

Sensitivity laplacian ratio-based optimization of the projection selection for diffuse optical tomography

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