Volumetric mass transfer coefficient in viscous liquid in mechanically agitated fermenters. Measurement and correlation

Labík, Libor; Moucha, T.; Petříček, Radim; Rejl, F.J.; Valenz, L.; Haidl, Jan

doi:10.1016/j.ces.2017.04.006

Cited by 24 publications

(8 citation statements)

References 68 publications

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“…dynamic viscosity, also known as absolute viscosity) is an important transport property as it is directly related to the mass transfer rate. 127 Among the factors affecting viscosity, temperature is an important one, and viscosity should be always given at the measured (or calculated) temperature to make any sense. For most fluids, the viscosity can vary nonlinearly many orders of magnitude with changes in temperature.…”

Section: Viscosity Gmentioning

confidence: 99%

The peculiar effect of water on ionic liquids and deep eutectic solvents

et al. 2018

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Section: Viscosity Gmentioning

confidence: 99%

The peculiar effect of water on ionic liquids and deep eutectic solvents

et al. 2018

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“…Various methods (e.g., power‐law, dimensionless correlations, etc.) have been developed to estimate mass transfer coefficient in stirred tank reactors . Among the methods, correlations in the form of power‐law equations have been most commonly used .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of volumetric mass transfer coefficient in a stirred tank bioreactor using response surface methodology

Lone

Kumar

Seay

et al. 2018

Env Prog and Sustain Energy

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Stirred tank reactors are most commonly used both in the laboratory and industry. Particularly for bioreactors, the volumetric mass transfer coefficient (kLa) of oxygen is used as one of the important parameters for determining efficiencies of reactors and for successful scale‐up. A number of correlation methods have been previously developed to predict the kLa in stirred tank bioreactors. In the present work, we propose a new correlation for kLa based on a mathematical and statistical approach using Response Surface Methodology (RSM) based on Box‐Behnken design of experiments. This correlation includes the effect of various parameters such as impeller agitation rate (50–800 rpm), air flow rate (0.5–3.5 L/min), and temperature (10−40°C) for different impeller configurations (single and dual Rushton, pitched blade, and mixed turbines). It was observed that the kLa increases with increasing the parameters for all the impeller configurations studied. Among the operating parameters, the most significant variable impacting kLa was found to be agitation rate, followed by air flow rate, and temperature. The models developed using RSM successfully interpreted the experimental kLa and were further validated under other operating conditions. It was also found that, compared with conventional power‐law models, the RSM approach enables a more efficient correlation procedure and formulates simplified models with comparably high accuracy, suggesting that the RSM is promising for evaluation of oxygen mass transfer in stirred tank bioreactors. © 2018 American Institute of Chemical Engineers Environ Prog, 38: 387–401, 2019

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“…Labík 27 suggested to modify Eq. 14 by adding the power number to the correlation:

true \frac{k_{normalL} a l^{2}}{D_{normalL}} = C_{1} {(\frac{ND}{ε ϑ_{normalL}^{1 normalfalse/ 4}})}^{{normalC}_{2}} {(\frac{v_{normalS}}{v_{normalT}})}^{{normalC}_{3}} P_{0}^{{normalC}_{4}}

…”

Section: Theorymentioning

confidence: 99%

Mass Transfer Prediction in a Mechanically Stirred Gas‐Liquid Reactor Containing Solid Particles

et al. 2021

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Microorganisms are used in various fermentation processes for the production of biochemicals and food. These types of processes take place predominantly in mechanically agitated vessels. An important transport characteristic is the volumetric mass transfer coefficient kLa. Many correlations are available in the literature to estimate parameters in a gas‐liquid system; however, three‐phase systems are not sufficiently described. The experiments were carried out under laboratory conditions in a single‐impeller mechanically agitated vessel with an internal diameter of 0.29 m. The solid phase was either cellulose, with two different particle sizes, or glass beads. An updated correlation is proposed that could be adopted in the design and scale‐up of agitated devices operating in the presence of solid particles.

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Volumetric mass transfer coefficient in viscous liquid in mechanically agitated fermenters. Measurement and correlation

Cited by 24 publications

References 68 publications

The peculiar effect of water on ionic liquids and deep eutectic solvents

The peculiar effect of water on ionic liquids and deep eutectic solvents

Evaluation of volumetric mass transfer coefficient in a stirred tank bioreactor using response surface methodology

Mass Transfer Prediction in a Mechanically Stirred Gas‐Liquid Reactor Containing Solid Particles

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