Volumetric Modulated Arc Therapy (VMAT) make a difference in retro-orbital irradiation treatment of patients with bilateral Graves’ ophthalmopathy. Comparative analysis of dosimetric parameters from different radiation techniques

San-Miguel, Iñigo; Carmona, Ruth; Luque, Luis Alejo; Cabrera, R.; Lloret, M.; Rutllan, Francisco; Lara, Pedro C.

doi:10.1016/j.rpor.2016.03.001

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Some scholars also applied it to GO radiotherapy. San Miguel et al [21] found that VMAT achieved better CI than 3D-CRT, and showed signi cant bene ts in sparing OARs (lens, eyeball, retina, and lacrimal gland) protection. Another study compared IMRT and VMAT techniques, and found that IMRT had a slight advantage in target homogeneity and OARs sparing, while VMAT had a shorter treatment time and improved the treatment tolerance [22].…”

Section: Discussionmentioning

confidence: 99%

Comparison of HyperArc, IMRT, and VMAT plans for Graves’ ophthalmopathy radiotherapy

Zhu,

Zhang,

Peng

et al. 2023

Preprint

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Objective To compare the dosimetric parameters of three different radiotherapy techniques, HyperArc (HA), volumetric modulated arc therapy (VMAT), and intensity-modulated radiotherapy (IMRT), for patients with Graves’ ophthalmopathy (GO), and to provide guidance for the clinical choice of radiotherapy methods for GO. Materials and Methods Eight patients with GO were enrolled in this study. HA, IMRT, and VMAT plans were generated for each patient. The dosimetric parameters of the target and the organs at risk (OARs) were compared and analyzed among the three plans. Results Compared with VMAT and IMRT plans, the HA plan had a higher conformity index (CI) (HA vs. VMAT, p = 0.012; HA vs. IMRT, p = 0.012) and homogeneity index (HI) (HA vs. VMAT, p = 0.042; HA vs. IMRT, p = 0.012), a lower gradient index (GI) (HA vs. VMAT, p = 0.012; HA vs. IMRT, p = 0.012) and a lower dose to the optic chiasm (HA vs. VMAT, p = 0.012; HA vs. IMRT, p = 0.012) and the brainstem maximum dose (HA vs. VMAT, p = 0.025; HA vs. IMRT, p = 0.017). The dose to lenses and the brain were similar to those in VMAT and IMRT plans (p > 0.05). The dose to the eyeballs slightly increased (left eye: HA vs. VMAT, p = 0.036; HA vs. IMRT, p = 0.012. Right eye: HA vs. VMAT, p = 0.012; HA vs. IMRT, p = 0.012). The machine unit (MU) of the HA plan is the lowest among the three plans. Conclusion For radiotherapy of GO, HA, IMRT, and VMAT are all feasible techniques. Compared with IMRT and VMAT, HA has better target coverage and conformity, homogeneity, and dose gradient, as well as better sparing of critical OARs, while saving treatment time. HA can be considered as the preferred technique for radiotherapy of GO.

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Section: Discussionmentioning

confidence: 99%

Comparison of HyperArc, IMRT, and VMAT plans for Graves’ ophthalmopathy radiotherapy

Zhu,

Zhang,

Peng

et al. 2023

Preprint

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“…However, the brain dose was not calculated with these modulated treatment techniques in the above reports. 35,36 Further research is required to find whether IMRT and/or VMAT can restrict the brain dose and the relevant probability of carcinogenesis compared to those associated with 3D radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The aforementioned increases of the LIR related to the appearance of brain cancer following therapeutic irradiation of GO should be considered as significant. The use of intensity modulated radiation therapy and volumetric modulated arc therapy for the management of GO may result in a better dose sparing of several adjacent structures than that observed with 3D conformal radiotherapy. However, the brain dose was not calculated with these modulated treatment techniques in the above reports .…”

Section: Discussionmentioning

confidence: 99%

“…The use of intensity modulated radiation therapy and volumetric modulated arc therapy for the management of GO may result in a better dose sparing of several adjacent structures than that observed with 3D conformal radiotherapy. However, the brain dose was not calculated with these modulated treatment techniques in the above reports . Further research is required to find whether IMRT and/or VMAT can restrict the brain dose and the relevant probability of carcinogenesis compared to those associated with 3D radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Risk of developing radiogenic cancer following photon‐beam radiotherapy for Graves’ orbitopathy

et al. 2018

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Evaluation of the conformity of intensity-modulated radiation therapy and volumetric modulated arc therapy using AAPM TG 119 protocol

Tam,

Ho,

et al. 2024

Radiat Environ Biophys

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Volumetric Modulated Arc Therapy (VMAT) make a difference in retro-orbital irradiation treatment of patients with bilateral Graves’ ophthalmopathy. Comparative analysis of dosimetric parameters from different radiation techniques

Abstract: VMAT Dosimetric parameters a b s t r a c tBackground: Graves' ophthalmopathy is the commonest extrathyroidal manifestation of

Cited by 5 publications

References 19 publications

Comparison of HyperArc, IMRT, and VMAT plans for Graves’ ophthalmopathy radiotherapy

Comparison of HyperArc, IMRT, and VMAT plans for Graves’ ophthalmopathy radiotherapy

Risk of developing radiogenic cancer following photon‐beam radiotherapy for Graves’ orbitopathy

Evaluation of the conformity of intensity-modulated radiation therapy and volumetric modulated arc therapy using AAPM TG 119 protocol

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