Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis

Fuerst, Darren R.; Shah, Jagdish; Kupsky, William J.; Johnson, Robert R.; Shah, Aashit; Hayman‐Abello, Brent; Ergh, Tanya C.; Poore, Quintin E.; Canady, Alexa; Watson, Craig

doi:10.1212/wnl.57.2.184

Cited by 92 publications

(68 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are consistent with the notion of a dual impact on the ipsilateral hippocampus [26]. In contrast, contralateral hippocampal volume was not significantly related to either of these variables and appears to maintain an independent course of development.…”

Section: Hippocampussupporting

confidence: 88%

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

Pulsipher

Seidenberg

Morton

et al. 2007

Epilepsy & Behavior

View full text Add to dashboard Cite

Few studies have examined the relative degree of brain volume loss in both the hippocampi and subcortical structures in unilateral temporal lobe epilepsy (TLE), and their association with clinical seizure correlates. In this study, quantitative MRI volumes were measured in the hippocampus, thalamus, caudate, putamen, and corpus callosum in 48 unilateral TLE patients (26 rights, and 22 lefts) and compared to 29 healthy controls. The ipsilateral hippocampus, corpus callosum, and bilateral thalami showed the greatest volume loss, reflected by large to moderate effect size differences compared to controls. Bilaterally, the putamen showed the next highest volume reduction. The contralateral hippocampus and bilateral caudate nuclei showed the least volume reduction, characterized by small effect sizes. Furthermore, clinical seizure characteristics (e.g, duration of epilepsy) showed different patterns of association with the volume reductions observed across these structures. Findings suggest that distinct neurodevelopmental features may play a role in the volume abnormality observed in these regions.

show abstract

Section: Hippocampussupporting

confidence: 88%

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

Pulsipher

Seidenberg

Morton

et al. 2007

Epilepsy & Behavior

View full text Add to dashboard Cite

show abstract

“…Patients with frequent generalized tonic-clonic seizures had smaller hippocampal volumes and lower N-acetylaspartate-to-creatine values than did patients with infrequent generalized seizures. Similar conclusions were drawn in two other studies of patients with uncontrolled complex partial seizures, which showed that hippocampal volume shrinkage was associated with both a history of complex or prolonged febrile seizures and epilepsy duration (32,33). These results suggest that the original hippocampal injury may be early and fixed, but that frequent seizures cause progressive neuronal dysfunction or loss (31).…”

Section: Clinical Datasupporting

confidence: 87%

Is Refractory Epilepsy Preventable?

et al. 2002

View full text Add to dashboard Cite

Summary: About a third of the patients diagnosed with epilepsy will not be fully controlled with antiepileptic drugs (AEDs), and many of them will have frequent and disabling seizures. These patients will undergo multiple drug trials, most often without complete seizure remission. Moreover, refractory epilepsy is associated with increased morbidity (from seizures and medications), social isolation, unemployment, and overall reduced quality of life. There is evidence that refractory epilepsy can be a progressive disorder, which, if controlled early, might never develop into a full syndrome with all of its associated sequelae. The difficulty lies in identifying at an early stage patients who are likely to progress to intractability. No currently known markers enable clinicians to make this identification with confidence. Advances in pharmacogenomics and our understanding of pharmacologic responsiveness in epilepsy may change this situation. Even now, we are able to identify many patients with a poor prognosis earlier than before, particularly in the pediatric population, in which syndromic classification may provide an approach to predict intractability. The early initiation of aggressive therapy may improve outcome and overall quality of life.

show abstract

“…Most common forms of epilepsy are not explained by the genes discovered so far, and their genetics appears to be "complex," resulting from multiple genes of small to moderate effect. Temporal lobe epilepsy (TLE), a common type of epilepsy that is frequently refractory to medical therapy, presents similar challenges because of its genetic complexity (Engel 2001;Fuerst et al 2001; Semah et al 1998; Stephen et al 2001). …”

Section: Introductionmentioning

confidence: 99%

Use of chromosome substitution strains to identify seizure susceptibility loci in mice

et al. 2007

View full text Add to dashboard Cite

Seizure susceptibility varies among inbred mouse strains. Chromosome substitution strains (CSS), in which a single chromosome from one inbred strain (donor) has been transferred onto a second strain (host) by repeated backcrossing, may be used to identify quantitative trait loci (QTLs) that contribute to seizure susceptibility. QTLs for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not been reported, and CSS have not previously been used to localize seizure susceptibility genes. We report QTLs identified using a B6 (host) × A/J (donor) CSS panel to localize genes involved in susceptibility to pilocarpine-induced seizures. Three hundred fifty-five adult male CSS mice, 58 B6, and 39 A/J were tested for susceptibility to pilocarpine-induced seizures. Highest stage reached and latency to each stage were recorded for all mice. B6 mice were resistant to seizures and slower to reach stages compared to A/J mice. The CSS for Chromosomes 10 and 18 progressed to the most severe stages, diverging dramatically from the B6 phenotype. Latencies to stages were also significantly shorter for CSS10 and CSS18 mice. CSS mapping suggests seizure susceptibility loci on mouse Chromosomes 10 and 18. This approach provides a framework for identifying potentially novel homologous candidate genes for human temporal lobe epilepsy.

show abstract

Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis

Abstract: Unilateral HS patients with earlier seizure onset and longer duration of epilepsy have more severe HS and greater hippocampal volume asymmetry. This suggests that HS may be a progressive disorder with risk for cognitive dysfunction.

Cited by 92 publications

References 36 publications

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

Is Refractory Epilepsy Preventable?

Use of chromosome substitution strains to identify seizure susceptibility loci in mice

Contact Info

Product

Resources

About