Volumetric properties of 1,2-propanediol + ethanol mixtures at different temperatures

Jimenez, Jackson; Martínez, Fleming

doi:10.1080/00319100600644169

Cited by 25 publications

(12 citation statements)

References 11 publications

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“…Titrations with different ratios (1:2.5, 1:3.75 and 1:5.0) of metal-ligand were performed with 0.4 mol dm -3 sodium hydroxide. Volume correction was not taken in to consideration because the increase in volume was insignificant even though the PG and water mixtures showed non-ideal behaviour due to increased interactions between unlike molecules and large differences in molar volumes of pure components (Jiménez and Martínez, 2005). During the titrations a stream of nitrogen was bubbled through for maintaining an inert atmosphere.…”

Section: Methodsmentioning

confidence: 99%

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Hirpaye

Rao

2013

Chemical Speciation & Bioavailability

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Chemical speciation of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 2,3-dihydroxybenzoic acid in 0.0-60.0% v/v 1, 2-propanediol-water mixtures maintaining an ionic strength of 0.16 mol dm -3 at 303±0.1 K has been studied pH metrically. The predominant complexes formed are ML, ML 2 and ML 2 H 2 for Co(II), Ni(II) and Zn(II) and ML, ML 2 , ML 2 H and ML 2 H 2 for Cu(II). Models containing different numbers of species were refined by using the computer program MINIQUAD75. Selection of the best fit chemical models was based on statistical parameters and residual analysis. The trend in variation of complex stability constants with dielectric constant of the medium is explained on the basis of electrostatic and non-electrostatic forces. Distributions of species, formation equilibria and effect of influential parameters on the stability constants have been presented. The possible structures of the various species are elucidated on the basis of the analysis of the pH-metric data.

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Section: Methodsmentioning

confidence: 99%

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Hirpaye

Rao

2013

Chemical Speciation & Bioavailability

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“…In order to use the IKBI method, the correlation volume was iterated three times by using the equations (2), (7) and (8) to obtain the values reported in Table 5. It is interesting to note that this value is almost independent on temperature in water-rich mixtures but increases in some extent in PG-rich mixtures as expectable according to the respective molar expansibilities [20]. ).…”

Section: Resultsmentioning

confidence: 83%

Preferential Solvation of Acetaminophen in Propylene Glycol + Water Co-Solvent Mixtures

Delgado¹,

Peña²,

Martínez³

2014

J. Appl. Sol. Chem. Model.

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The preferential solvation parameters defined as the differences between the local mole fraction of solvents around analgesic drug acetaminophen and those for the bulk co-solvent composition in propylene glycol + water mixtures were derived from their thermodynamic properties by means of the inverse Kirkwood-Buff integrals (IKBI) and the quasi-lattice-quasi-chemical (QLQC) methods. It is found that acetaminophen is sensitive to solvation effects, so according to IKBI method the preferential solvation parameter xPG,A, is negative in water-rich mixtures but positive in medium compositions and in co-solvent-rich mixtures. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic ring and methyl group present in the drug plays a relevant role in the solvation. The bigger drug solvation by co-solvent in mixtures of similar solvent proportions and in propylene glycol-rich mixtures could be due mainly to polarity effects. Otherwise, according to QLQC method, this drug is preferentially solvated by the co-solvent in all the mixtures.

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“…It is interesting to note that these V cor values are almost independent on temperature in water-rich mixtures (i.e. at x 1 = 0.00 and 0.10) but they increase in some extent in cosolvent-rich mixtures as expectable according to the variation of the respective molar expansibilities with the mixtures composition (Jiménez et al, 2004;Jiménez and Martínez, 2005). Nevertheless a very interesting behavior is observed in EtOH + water mixtures with composition 0.50 ≤ x 1 ≤ 0.70 where no clear dependence of V cor with temperature is observed.…”

Section: Resultsmentioning

confidence: 96%

Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures

Peña

Delgado

Martínez

2015

Chemical Engineering Communications

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The preferential solvation parameters for indomethacin (IMC) in ethanol (EtOH) + water and propylene glycol (PG) + water binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood-Buff integrals (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by co-solvents, (δx 1,3 ), is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15 and 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic rings and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by co-solvent in mixtures of similar solvent proportion and in co-solvent-rich mixtures could be due mainly to polarity effects. Here IMC would be acting as a Lewis acid with the EtOH or PG molecules because these co-solvents are more basic than water.

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Volumetric properties of 1,2-propanediol + ethanol mixtures at different temperatures

Cited by 25 publications

References 11 publications

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Preferential Solvation of Acetaminophen in Propylene Glycol + Water Co-Solvent Mixtures

Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures

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