Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan

Dong, Chuan; Zhang, Li; Zheng, Fenglian; Wang, Huiqin; Meng, Qingduan; Lu, Wen; Liu, Zhipeng; Yin, Tao; Qiu, Jianfeng

doi:10.21037/qims.2019.10.19

Cited by 13 publications

(16 citation statements)

References 56 publications

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“…Importantly, the cerebellum has been shown also to be one of the most affected regions under normal aging. For instance, the cerebellum shows reductions in gray matter volume and white matter integrity as a function of aging to the same level as those observed in PFC and only slightly less severe than those observed within the hippocampus [9,14,31,34]. Moreover, the cerebellar volume correlates with scores in memory tests [9,13,31,42], and the cerebellum shows under activation in memory and other cognitive tasks under aging [34].…”

Section: Introductionmentioning

confidence: 81%

“…Typically, the field has focused on the role (and age-related decline) of medial temporal lobe (MTL) structures, such as the hippocampus, and of the prefrontal cortex (PFC) in episodic memory [3,4,6]. However, a relatively recent emerging candidate for having a central role in episodic memory performance, and in overall cognitive decline under aging, is the cerebellum [7][8][9][10][11][12][13]. Here, we hypothesize that the cerebellum plays a causal role in episodic memory performance under healthy aging.…”

Section: Introductionmentioning

confidence: 99%

“…However, this has been heavily challenged in the last decades: the contribution of the cerebellum (and potentially those parts of the cerebellum that are more phylogenetically recent) goes well beyond that of motor coordination and impacts decisively on cognitive and emotional processes [7,[28][29][30][31][32][33]. For instance, the cerebellum has been shown to be involved among other things in verbal working memory [9,11,32], procedural learning [7], accurate timing of multiple signals and time judgments [7,9], verbal learning [7], and language production [7]. Importantly, the cerebellum has also been associated with episodic memory performance (in particular verbal episodic memory) [7-13, 34, 35].…”

Section: Introductionmentioning

confidence: 99%

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The cerebellum is causally involved in episodic memory under aging

et al. 2023

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Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period — healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The cerebellum is causally involved in episodic memory under aging

et al. 2023

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“…7, 8 Cui, Zhang measured the volume changes in the cerebellar region with the VolBrain method in their study and evaluated the relationship between lobules at different ages and their reduced memory recall abilities. 9 We used the segmentation method with the default volBrain T1 volumetric images. We analyzed the total cerebellum volumes of patients with vestibular neuritis and those in the control group.…”

Section: Introductionmentioning

confidence: 99%

Vesti̇büler Nöri̇t Hastalarinda Cerebellum'un Manyeti̇k Rezonans 3d T1 Segmentasyonlarinin Anali̇zi̇

Ocak

Yılmaz

Avnioğlu³

et al. 2022

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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Aim: Vestibular neuritis is one of the most common causes of acute spontaneous vertigo. In our study, we aimed to analyze the cerebellum volume and cerebellum connections in patients diagnosed with vestibular neuritis using the VolBrain program. Materials and Methods: 10 patients and 9 healthy (control) persons were included in the study. Automatic segmentation and volumetric analysis of cerebellum and cerebellum lobules were investigated using magnetic resonance images (MRI) of 19 people. Results: The volumes of 10 cerebellar regions were measured and compared between the patient and control groups. The total volume of the cerebellum was calculated as 123.82 ± 2.57 cm3 in the control group and 119.97 ± 4.15 cm3 in the patient group. In addition, the average amount of gray matter in the cerebellum was 90.63 ± 6.59 cm3 in the control group and 87.87 ± 16.12 cm3 in the patient group. We found volumetric changes to be statistically significant. Conclusion: By performing cerebellum segmentation with 3D T1 sequence of MRI images taken from patients diagnosed with vestibular neuritis, volume measurement and more detailed examinations can be performed easily with the help of the volBrain program. Moreover, its low cost and its usefulness in diagnosis suggest that this method will be beneficial.

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“…As age increases, so does the likelihood of having AD (12). Therefore, older age is one of the greatest risk factors for AD (13,14). Second, almost two-thirds of the population with AD is female.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of a T1 standard brain template for Alzheimer disease

Guo¹,

Chang²,

Kim³

et al. 2021

Quant Imaging Med Surg

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Background: Patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) have high variability in brain tissue loss, making it difficult to use a disease-specific standard brain template. The objective of this study was to develop an AD-specific three-dimensional (3D) T1 brain tissue template and to evaluate the characteristics of the populations used to form the template. Methods: We obtained 3D T1-weighted images from 294 individuals, including 101 AD, 96 amnestic MCI, and 97 cognitively normal (CN) elderly individuals, and segmented them into different brain tissues to generate AD-specific brain tissue templates. Demographic data and clinical outcome scores were compared between the three groups. Voxel-based analyses and regions-of-interest-based analyses were performed to compare gray matter volume (GMV) and white matter volume (WMV) between the three participant groups and to evaluate the relationship of GMV and WMV loss with age, years of education, and Mini-Mental State Examination (MMSE) scores.Results: We created high-resolution AD-specific tissue probability maps (TPMs). In the AD and MCI groups, losses of both GMV and WMV were found with respect to the CN group in the hippocampus (F >44.60, P<0.001). GMV was lower with increasing age in all individuals in the left (r=−0.621, P<0.001) and right (r=−0.632, P<0.001) hippocampi. In the left hippocampus, GMV was positively correlated with years of education in the CN groups (r=0.345, P<0.001) but not in the MCI (r=0.223, P=0.0293) or AD (r=−0.021, P=0.835) groups. WMV of the corpus callosum was not significantly correlated with years of education in any of the three subject groups (r=0.035 and P=0.549 for left, r=0.013 and P=0.821 for right). In all individuals, GMV of the hippocampus was significantly correlated with MMSE scores (left, r=0.710 and P<0.001; right, r=0.680 and P<0.001), while WMV of the corpus callosum showed a weak correlation (left, r=0.142 and P=0.015; right, r=0.123 and P=0.035).Conclusions: A 3D, T1 brain tissue template was created using imaging data from CN, MCI, and AD participants considering the participants' age, sex, and years of education. Our disease-specific template can help evaluate brains to promote early diagnosis of MCI individuals and aid treatment of MCI and AD individuals.

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Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan

Cited by 13 publications

References 56 publications

The cerebellum is causally involved in episodic memory under aging

The cerebellum is causally involved in episodic memory under aging

Vesti̇büler Nöri̇t Hastalarinda Cerebellum'un Manyeti̇k Rezonans 3d T1 Segmentasyonlarinin Anali̇zi̇

Development and evaluation of a T1 standard brain template for Alzheimer disease

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