Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: The role of hippocampal brain-derived neurotrophic factor

Miladi‐Gorji, Hossein; Rashidy-Pour, Ali; Fathollahi, Yaghoub; Akhavan, M.; Semnanian, Saeed; Safari, Manouchehr

doi:10.1016/j.nlm.2011.08.001

Cited by 59 publications

(28 citation statements)

References 82 publications

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“…The finding that chronic use of opiates decreases the number of hippocampal neurons is in parallel with a poor performances of morphine-dependent rats on memory tasks (15). Voluntary exercise restored both the capacity of neuronal counting and the performances in the water maze test.…”

Section: Discussionmentioning

confidence: 93%

“…It seems that an interaction between BDNF and the number of neurons in the hippocampus may influence cognitive functions and plasticity in those with opiate dependency; increased levels of BDNF in exercising rats (15) in parallel with increasing the number of neurons in the hippocampus can ameliorate the spatial memory deficits in morphine-dependent rats. The finding that chronic use of opiates decreases the number of hippocampal neurons is in parallel with a poor performances of morphine-dependent rats on memory tasks (15).…”

Section: Discussionmentioning

confidence: 99%

“…Animals received subcutaneous injection of morphine sulfate (10 mg/kg) twice a day at 12 hours intervals for ten days as described previously (15). Control rats received normal saline instead of morphine.…”

Section: Animals and Dependency Inductionmentioning

confidence: 99%

“…We prepared microspheres using methods described elsewhere. Each rat received injections of 2 μL of TrkB-IgG or Cyt C using a Hamilton syringe, over a period of 15 minute (15).…”

Section: Animals and Preparation Of Microbeadsmentioning

confidence: 99%

“…In human subjects and in rodents, voluntary or forced exercises promote neurogenesis in the adult dentate gyrus (DG) (7) and brain-derived neurotrophic factor (BDNF) might have a potential role in exercise-induced neurogenesis, synaptic plasticity, and memory through its actions on the tyrosine kinase B (TrkB) receptor (8)(9)(10)(11)(12)(13)(14). We have recently demonstrated that voluntary exercise diminishes the severity of morphine dependency (15) and the anxiogenic-like behaviors in both morphine-dependent and withdrawn rats (16), enhances LTP in hippocampal DG area (17), and ameliorates the spatial memory deficits in morphine-dependent rats through TrkB receptor of BDNF (15).…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Rashidy-Pour

Fathollahi

Miladi‐Gorji

et al. 2015

Middle East J Rehabil Health

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Background: Exposure to morphine decreases neurogenesis in the hippocampus. Recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. Objectives: This study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be reversed by voluntary running through a brain-derived neurotrophic factor (BDNF)-mediated mechanism. Materials and Methods: The rats were received injections of 10 mg/kg of morphine twice a day over ten days of voluntary running. A specific antagonist of BDNF action (TrkB-IgG) was used to block the hippocampal BDNF action during the study period; cytochrome C (Cyt C) was used as the control drug. Results: We found that chronic exposure to morphine had decreased the number of dentate gyrus neurons in sedentary rats receiving Cyt C or IgG in comparison to the control rats (P < 0.05). Moreover, exercise groups receiving saline or morphine showed an increase in the number of neurons following ten days running; blocking the BDNF action with TrkB-IgG fully inhibited this effect (both, P = 0.0001). Conclusions: This study demonstrates that that voluntary exercise can ameliorate the attenuation of hippocampal neuron number induced by morphine dependence through a BDNF-mediated mechanism. Thus, physical activity might have a potential role in ameliorating chronic morphine-induced neuronal changes in the hippocampus.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Animals and Dependency Inductionmentioning

confidence: 99%

“…We prepared microspheres using methods described elsewhere. Each rat received injections of 2 μL of TrkB-IgG or Cyt C using a Hamilton syringe, over a period of 15 minute (15).…”

Section: Animals and Preparation Of Microbeadsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Rashidy-Pour

Fathollahi

Miladi‐Gorji

et al. 2015

Middle East J Rehabil Health

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Effect of enriched environment during adolescence on spatial learning and memory, and voluntary consumption of morphine in maternally separated rats in adulthood

Mohammadian

Najafi

Miladi‐Gorji

2018

Developmental Psychobiology

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This study was designed to examine the effect of environmental enrichment (EE) during adolescence on spatial learning and memory and voluntary morphine consumption in maternally separated (MS) male and female rats in adulthood. Male Wistar rats were allowed to mate with female virgin Wistar rats. Pups were separated from the dams daily for 180 min during postnatal days 2–14. All pups were weaned on day 21. The pups of both sexes were reared in a standard (SE) or enriched (EE) environment during postnatal days 21–50. Then, adulthood rats were tested for spatial learning and memory (Morris Water Maze), and voluntary consumption of morphine using a two‐bottle choice paradigm (TBC). We found that the MS/SE rats showed longer escape latencies to find the platform on the third (the male) and fourth (the female) days of training than No MS/SE rats. Also, exposure to EE shortened the latency to escape in the male and female MS rats as training progressed than MS/SE rats. Moreover, the No MS/EE and MS/EE male rats spent significantly more time in the target zone compared with the SE control groups in the probe test. We also found that voluntary morphine consumption was higher in the male and female MS/SE than No MS/SE rats, while it was lower in the male and female MS/EE rats. The present results have shown that EE treatment may have potential therapeutic application for the prevention of the development of drug addiction and recovery from cognitive deficits following neonatal MS during adulthood.

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Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

Marrero-Cristobal

Gelpi-Dominguez

Morales-Silva

et al. 2021

J of Neuroscience Research

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Substance use disorder (SUD) is a complex condition that involves the induction of molecular and physiological alterations by the use and abuse of illicit substances. The prevalence of illicit drug use has caused this disorder to grow exponentially over the past 5 years (National Institute of Drug Abuse, 2020). To date, there are several FDA-approved pharmacological treatments for substances that may cause dependency, such as heroin, morphine, alcohol, and nicotine, directed to the attenuation of drug craving, and increase time to relapse. Known as medication-assisted treatment, such FDA-approved pharmaceutical interventions can be used to increase the effectiveness of other substance abuse treatments, including the use of buprenorphine (commonly used in opioid use disorder, OUD).Buprenorphine works as a partial agonist that binds to the opioid receptors in the brain, allowing a partial activation of the receptor when it is activated with opioids, and thus reducing the rewarding effects (James & Williams, 2020). Another FDA-approved treatment for OUD is naloxone, a known opioid receptor antagonist that reduces activation and prevents other endogenous ligands to bind to that receptor (Becker & Chartoff, 2019;James & Williams, 2020). These types of pharmacological treatments are still not available for substances such as cocaine, methamphetamines, or cannabis which limit treatment options. The percentage cocaine users aged

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Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: The role of hippocampal brain-derived neurotrophic factor

Cited by 59 publications

References 82 publications

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Effect of enriched environment during adolescence on spatial learning and memory, and voluntary consumption of morphine in maternally separated rats in adulthood

Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

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