2021
DOI: 10.21203/rs.3.rs-882647/v1
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Voluntary Exercise Ameliorates Neuropathic Pain by Suppressing Calcitonin Gene-Related Peptide and Ionized Calcium-Binding Adapter Molecule 1 Overexpression in the Lumbar Dorsal Horns in Response to Injury to the Cervical Spinal Cord

Abstract: Background Neuropathic pain (NP) is a frequent finding in patients diagnosed with spinal cord injuries (SCIs). We aimed to investigate the effects of voluntary exercise on NP after SCI and to elucidate its potential mechanisms. MethodsA rat model of post-SCI NP induced by compression of the posterior or lateral cervical spinal cord was used to evaluate the effects of voluntary exercise by measuring the bilateral withdrawal of the hind paws using the Von Frey filament and Hargreaves tests. The place escape… Show more

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