Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice

Otsuka, Airi; Shiuchi, Tetsuya; Chikahisa, Sachiko; Shimizu, Noriyuki; Séi, Hiroyoshi

doi:10.1016/j.physbeh.2015.07.024

Cited by 21 publications

(9 citation statements)

References 37 publications

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“…Interestingly, VWR could reverse the impairment of social preference and deficiency in social interaction induced by CSDS. This is consistent with previous studies where exercise before or in the process of CSDS can reverse social avoidance of defeated mice (Otsuka et al, 2015; Mul et al, 2018). The time of VWR in the present study is more similar to the treatment of psychiatric disorders using antidepressants in human.…”

Section: Discussionsupporting

confidence: 93%

“…The time of VWR in the present study is more similar to the treatment of psychiatric disorders using antidepressants in human. This finding is supported by several lines of evidence, reporting that physical exercise can effectively relieve psychopathological disorders, and the effect of exercise is similar to or more significant than that of a psychological intervention and antidepressant treatment (Blumenthal et al, 2007; Hoffman et al, 2011; Otsuka et al, 2015; Kingston et al, 2018). These results suggest that voluntary exercise is an effective way to treat social interaction disorders induced by social stress.…”

Section: Discussionsupporting

confidence: 54%

“…A recent report showed that VWR reverses high levels of defensive/submissive behaviors induced by a single social defeat stress in Syrian hamsters (Kingston et al, 2018). Otsuka et al pointed out that voluntary running on a wheel for 2 h can reduce the social avoidance behavior induced by CSDS (Otsuka et al, 2015). However, whether brain monoamine levels are altered by VWR remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System

Zhang

Wang

et al. 2019

Front. Neurosci.

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Voluntary exercise has been reported to have a therapeutic effect on many psychiatric disorders and social stress is known to impair social interaction. However, whether voluntary exercise could reverse deficits in social behaviors induced by chronic social defeat stress (CSDS) and the underlying mechanism remain unclear. The present study shows CSDS impaired social preference and induced social interaction deficiency in susceptible mice. Voluntary wheel running (VWR) reversed these effects. In addition, CSDS decreased the levels of tyrosine hydroxylase in the ventral tegmental area and the D2 receptor (D2R) in the nucleus accumbens (NAc) shell. These changes can be recovered by VWR. Furthermore, the recovery effect of VWR on deficits in social behaviors in CSDS mice was blocked by the microinjection of D2R antagonist raclopride into the NAc shell. Thus, these results suggest that the mechanism underlying CSDS-induced social interaction disorder might be caused by an alteration of the dopamine system. VWR may be a novel means to treat CSDS-induced deficits in social behaviors via modifying the dopamine system.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System

Zhang

Wang

et al. 2019

Front. Neurosci.

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“…In this same mouse strain, 2h access to a running wheel 376 immediately after each defeat session during 10 days of CSDS potentially 377 ameliorated stress-related effects on social behavior, although the study seems to 378 suffer from being underpowered (Otsuka, et al 2015). We have observed in male 379 …”

Section: Chronic Social Defeat Stress (Csds) 372mentioning

confidence: 88%

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

Mul

2018

Journal of Molecular Endocrinology

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Acute or chronic exposure to stress can increase the risk to develop major depressive disorder, a severe, recurrent and common psychiatric condition. Depression places an enormous social and financial burden on modern society. Although many depressed patients are treated with antidepressants, their efficacy is only modest, underscoring the necessity to develop clinically effective pharmaceutical or behavioral treatments. Exercise training produces beneficial effects on stress-related mental disorders, indicative of clinical potential. The pro-resilient and antidepressant effects of exercise training have been documented for several decades. Nonetheless, the underlying molecular mechanisms and the brain circuitries involved remain poorly understood. Preclinical investigations using voluntary wheel running, a frequently used rodent model that mimics aspects of human exercise training, have started to shed light on the molecular adaptations, signaling pathways and brain nuclei underlying the beneficial effects of exercise training on stress-related behavior. In this review, I highlight several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and review recent rodent studies that utilized voluntary wheel running to promote our understanding of exercise training-induced central adaptations. Advancements in our mechanistic understanding of how exercise training induces beneficial neuronal adaptations will provide a framework for the development of new strategies to treat stress-associated mental illnesses.

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“…Furthermore, mistimed feeding as circadian stressor adversely affecting circulating GCs can be reduced with scheduled meals. Food as well as scheduled activity during the natural activity phase enhances the circadian alignment of peripheral tissue clocks with the central master pacemaker ( Otsuka et al., 2015 ). However, ∼30% of employees in health care are shift working and suffer from circadian disruptions ( Arendt, 2010 ).…”

Section: Translational Considerationsmentioning

confidence: 99%

Interaction between circadian rhythms and stress

Koch

Leinweber

Drengberg

et al. 2017

Neurobiology of Stress

195

145

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Life on earth has adapted to the day-night cycle by evolution of internal, so-called circadian clocks that adjust behavior and physiology to the recurring changes in environmental conditions. In mammals, a master pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives environmental light information and synchronizes peripheral tissues and central non-SCN clocks to geophysical time. Regulatory systems such as the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), both being important for the regulation of stress responses, receive strong circadian input. In this review, we summarize the interaction of circadian and stress systems and the resulting physiological and pathophysiological consequences. Finally, we critically discuss the relevance of rodent stress studies for humans, addressing complications of translational approaches and offering strategies to optimize animal studies from a chronobiological perspective.

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Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice

Cited by 21 publications

References 37 publications

Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System

Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

Interaction between circadian rhythms and stress

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