Voluntary exercise or systemic propranolol ameliorates stress-related maladaptive behaviors in female rats

Robinson, Siobhan; Christ, Christa C.; Cahill, Margaret M.; Aldrich, Sara J.; Taylor-Yeremeeva, Elisa M.

doi:10.1016/j.physbeh.2018.10.012

Cited by 12 publications

(4 citation statements)

References 112 publications

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“…Finally, exercise minimized, or even reversed, the stress-induced changes in hippocampal neurogenesis, which correlated with improved cognitive functions in aged mice [ 52 ] and humans [ 53 ]. Treadmill exercise following or at the same time as an exposure to the social stressors induced by social defeat [ 54 ] or a PTSD model [ 55 , 56 ] resulted in the prevention of anxiety- and depression-like behaviour. Here, it is noteworthy that, as a result of a review by Holmes (2014) [ 57 ], the anxiolytic effects of exercise in rodents are most consistent when the subjects have previously been exposed to a stressor, thus distinguishing the preventive and the therapeutic effects of exercise.…”

Section: Discussionmentioning

confidence: 99%

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Nowacka-Chmielewska¹,

Grabowska

Grabowski

et al. 2022

IJMS

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Chronic stress, even stress of a moderate intensity related to daily life, is widely acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases. There is a clear relationship between disturbances induced by stressful stimuli, especially long-lasting stimuli, and cognitive deficits in rodent models of affective disorders. Regular physical activity has a positive effect on the central nervous system (CNS) functions, contributes to an improvement in mood and of cognitive abilities (including memory and learning), and is correlated with an increase in the expression of the neurotrophic factors and markers of synaptic plasticity as well as a reduction in the inflammatory factors. Studies published so far show that the energy challenge caused by physical exercise can affect the CNS by improving cellular bioenergetics, stimulating the processes responsible for the removal of damaged organelles and molecules, and attenuating inflammation processes. Regular physical activity brings another important benefit: increased stress robustness. The evidence from animal studies is that a sedentary lifestyle is associated with stress vulnerability, whereas a physically active lifestyle is associated with stress resilience. Here, we have performed a comprehensive PubMed Search Strategy for accomplishing an exhaustive literature review. In this review, we discuss the findings from experimental studies on the molecular and neurobiological mechanisms underlying the impact of exercise on brain resilience. A thorough understanding of the mechanisms underlying the neuroprotective potential of preconditioning exercise and of the role of exercise in stress resilience, among other things, may open further options for prevention and therapy in the treatment of CNS diseases.

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Section: Discussionmentioning

confidence: 99%

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Nowacka-Chmielewska¹,

Grabowska

Grabowski

et al. 2022

IJMS

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“…It is important to consider propranolol’s potential as a preventative treatment for chronically stressed individuals [ 50 ]. Propranolol reduced anxiety-like behaviours while also increasing resilience to a following stressor [ 51 ]. An oral dose of 80 mg propranolol lowered the rise in HR and systolic BP brought on by stress to 49.9% and 8.3%, respectively, as opposed to 61.0% and 17.4% with placebo.…”

Section: The Medical Use Of Propranololmentioning

confidence: 99%

“…The AMG’s ability to activate and store memories is thought to be modulated by stress hormones, which propranolol is known to inhibit [ 152 ]. Propranolol can help with stress-related symptoms via affecting AMG-dependent memory reconsolidation and peripheral noradrenergic signalling [ 51 ]. Preclinical studies have shown that a single dose of propranolol administered immediately after an intense stressor (exposure to a predator/predator scent, electric shock) blocks subsequent expression of anxiety-related behaviour [ 153 , 154 , 155 ], possibly by impairing the consolidation of the stressful experience.…”

Section: Mechanism Of Action Of Propranolol In the Treatment Of Ptsdmentioning

confidence: 99%

Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder

Szeleszczuk

Frączkowski

2022

IJMS

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Propranolol, a non-cardioselective β1,2 blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. This review focuses on the application of propranolol in the treatment of various types of anxiety and stress, with particular reference to stage fright and post-traumatic stress disorder (PTSD). Both mechanisms of action as well as comparison with other therapies are presented. As those indications for propranolol are, in most countries, considered off-label, this review aims to gather information that can be useful while making a decision about the choice of propranolol as a drug in the treatment of those mental conditions.

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“…2012,Leasure & Jones 2008, García- Capdevila et al 2009, Fuss et al 2010, Bouchet et al 2017, Mul et al 2018, Robinson et al 2019, Tanner et al 2019, Calpe-López Fulk et al 2004, Leasure & Jones 2008, Greenwood et al 2013, Lalanza et al 2015, Kochi et al 2017, Pietrelli et al 2018, Yan et al 2023 …”

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confidence: 99%

Potential resilience treatments for orangutans (Pongo spp.): Lessons from a scoping review of interventions in humans and other animals

Bridgeland-Stephens,

Thorpe,

Chappell

2023

Anim. welf.

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Wild orangutans (Pongo spp.) rescued from human-wildlife conflict must be adequately rehabilitated before being returned to the wild. It is essential that released orangutans are able to cope with stressful challenges such as food scarcity, navigating unfamiliar environments, and regaining independence from human support. Although practical skills are taught to orangutans in rehabilitation centres, post-release survival rates are low. Psychological resilience, or the ability to ‘bounce back’ from stress, may be a key missing piece of the puzzle. However, there is very little knowledge about species-appropriate interventions which could help captive orangutans increase resilience to stress. This scoping review summarises and critically analyses existing human and non-human animal resilience literature and provides suggestions for the development of interventions for orangutans in rehabilitation. Three scientific databases were searched in 2021 and 2023, resulting in 63 human studies and 266 non-human animal studies. The first section brings together human resilience interventions, identifying common themes and assessing the applicability of human interventions to orangutans in rehabilitation. The second section groups animal interventions into categories of direct stress, separation stress, environmental conditions, social stress, and exercise. In each category, interventions are critically analysed to evaluate their potential for orangutans in rehabilitation. The results show that mild and manageable forms of intervention have the greatest potential benefit with the least amount of risk. The study concludes by emphasising the need for further investigation and experimentation, to develop appropriate interventions and measure their effect on the post-release survival rate of orangutans.

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Voluntary exercise or systemic propranolol ameliorates stress-related maladaptive behaviors in female rats

Cited by 12 publications

References 112 publications

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder

Potential resilience treatments for orangutans (Pongo spp.): Lessons from a scoping review of interventions in humans and other animals

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