Objective: To investigate factors associated with adherence to viral mitigation strategies recommended by the WHO during the COVID-19 pandemic, including adherence to social distancing protocols (SDPs) and adherence to hygienic behavior recommendations (HB). Design: This pre-registered epidemiological study of 4158 adults examines the association between situational, cognitive, affective, behavioral, and personality-based factors with adherence to SDPs and HB during the COVID-19 pandemic. The study further investigates the relationship between central information sources and adherence behavior.Main Outcome Measures: Adherence to social distancing protocols (SDPs) and adherence to hygienic behavior recommendations (HB). Results: Individuals aged between 18-30 reported lowest adherence to SDPs and HB. Greater alcohol consumption was associated with decreased adherence to SDP and HB. Increased risk perception, fear of infection, conscientious personality, and altruistic attitude was associated with greater adherence to SDPs and HB. Males, single individuals, employed individuals, and those without children reported lower adherence to SDPs and HB. Extroverted personality and residents of urban areas were associated with lower adherence to SDPs, but not HB. In contrast to earlier stages of the pandemic, voluntary social distancing was associated with greater adherence to SDPs as opposed to rule-enforced (e.g., mandated) social distancing. Among information sources, increased time spent obtaining information from official (i.e., recognized) newspapers had the strongest favorable association with adherence to both SDPs and HB, followed by information obtainment from recognized television channels. Relying on information from friends and family was associated with decreased adherence to SDPs, but was unrelated to adherence to HB. Sensitivity analyses replicated the findings, supporting the stability and robustness of the proposed models. Conclusion: The present study identifies factors associated with favorable and detrimental adherence behavior along with substantial dissemination routes, presenting strategies which may be utility toward fostering adherence to contemporaneously implemented pandemic mitigation protocols.Key words: COVID-19; Adherence; Compliance; Social Distancing; Physical Distancing; Viral Mitigation; Hygienic Behavior