Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole

Watanasriyakul, W Tang; Wardwell, Joshua; McNeal, Neal; Schultz, Rachel; Woodbury, Matthew; Dagner, Ashley; Cox, Miranda; Grippo, Angela J.

doi:10.1080/17470919.2017.1365761

Cited by 11 publications

(8 citation statements)

References 85 publications

(103 reference statements)

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“…Exercise is also known to activate the HPA axis and increase circulating glucocorticoid levels (Gerber et al, 2013;Hill et al, 2008;Skoluda et al, 2012;Tremblay et al, 2004). However, under conditions of chronic stress, exercise mitigates glucocorticoid levels and reduces depression-and anxiety-like behaviors (Campeau et al, 2010;Grippo et al, 2014;Sasse et al, 2008;Watanasriyakul et al, 2018). Parts of the current study align well with these previously observed patterns.…”

Section: Discussionsupporting

confidence: 87%

“…Experimental animals in the isolated groups were housed individually, without olfactory, auditory, or visual cues from the previous sibling. Previous work with this species has demonstrated that this duration of isolation is sufficient to induce behavioral and physiological consequences Grippo et al, 2008;McNeal et al, 2014;Peuler et al, 2012), and that access to exercise can mitigate these effects (Watanasriyakul et al, 2018). At the end of the five-week stressor period, a second hair sample was collected from each experimental animal, plasma samples were collected, and adrenal and body weights were recorded.…”

Section: Study Outlinementioning

confidence: 99%

“…Based on negative effects of social instability in female mice (Jarcho et al, 2016), we also predicted that social isolation would be associated with increases in hair corticosterone concentrations. We further predicted that effects of isolation would be blunted or eliminated in animals that had access to an exercise wheel (Starzec et al, 1983;Watanasriyakul et al, 2018). Lastly, we predicted that certain physiological measures would be systematically correlated to one another.…”

Section: Introductionmentioning

confidence: 96%

“…Furthermore, the mechanism underlying the stress-buffering effects of exercise within the PVN remain unclear. On one hand, 6 weeks of wheel running buffered against adrenocortical responses and PVN reactivity to white noise in rats (Campeau et al, 2010), whereas 4 weeks of voluntary exercise buffered against corticosterone response but not PVN reactivity to a forced swim stressor in prairie voles (Watanasriyakul et al, 2018). This complication may be due to the fact that the PVN both initiates HPA stress responses and also integrates autonomic signals triggered by exercise (Evanson and Herman, 2015;Michelini and Stern, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Wheel access has opposing effects on stress physiology depending on social environment in female prairie voles (Microtus ochrogaster)

Jarcho

McNeal

Colburn

et al. 2019

Stress

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Physical exercise and chronic social stress are both known to impact general health and hypothalamic-pituitary-adrenal (HPA) axis function, albeit typically in opposing directions. Therefore, the question we investigated in this study was how these two factors-physical exercise and chronic social isolation-would interact when presented simultaneously in a female rodent model. Adult female prairie voles were separated into four experimental groups: 1) isolated without wheel access, 2) isolated with wheel access, 3) paired without wheel access, and 4) paired with wheel access. Plasma, hair, and adrenal glands were sampled to investigate changes in stress physiology. Our results indicate that, when isolated, wheel access had a mitigating effect on HPA activity. However, in paired animals, wheel access had the opposite effect, as both adrenal mass and increase in hair corticosterone concentrations were greater in paired animals with wheel access. Strong correlations were detected between change in hair corticosterone and adrenal mass, while no correlations were found between plasma corticosterone and either of the other markers. These results imply that the HPA axis is highly sensitive to both the social environment and the physical demands placed on the individual, and that when investigating the effects of chronic isolation, both hair corticosterone and adrenal mass may be more reliable markers than a single plasma corticosterone sample.

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Section: Discussionsupporting

confidence: 87%

Section: Study Outlinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wheel access has opposing effects on stress physiology depending on social environment in female prairie voles (Microtus ochrogaster)

Jarcho

McNeal

Colburn

et al. 2019

Stress

Self Cite

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“…Using a chronic mild stress model, Watanasriyakul et al, (183) active" people were less likely to have SI but also were protected against SI.…”

Section: Major Depressive Disordermentioning

confidence: 99%

Skeletal Muscle Arteriole Dysfunction and Microvessel Density in Metabolic Syndrome and Depression: How Exercise Can Be Used as an Intervention

Branyan¹

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The present study examined the effect of unpredictable chronic mild stress (UCMS) on peripheral microvessel function in healthy and metabolic syndrome (MetS) rodents, and whether exercise training could prevent the vascular dysfunction associated with UCMS. Our initial hypothesis was that: 1) LZRs exposed to UCMS would have peripheral microvascular dysfunction similar to that evident in the OZRs controls due to a reduction in NO bioavailability and an increase in ROS production; 2) the comorbidity between MetS exposed to UCMS will exacerbate the already existing peripheral microvascular dysfunction; 3) exercise could limit the peripheral microvascular dysfunction by decreasing oxidative stress and improving vasodilation associated with MetS exposed to chronic stress; 4) MVD will be reduced in rats exposed to UCMS but loss of MVD will be mitigated by exercise; and 5) the increase in MVD will be reflected by a change in angiogenesis and oxidative markers. Lean and obese (model of MetS) Zucker rats (LZR; OZR) were exposed to 8 weeks of UCMS, exercise (Ex), UCMS+Ex, or control conditions. At the end of the intervention, gracilis arterioles (GAs) were isolated and hung in a pressurized myobath to assess endothelium-dependent (EDD) and-independent (EID) dilation. Levels of nitric oxide (NO) and reactive oxygen species (ROS) were measured through DAF-FM and DHE staining, respectively. Immunohistochemistry was used to determine the number of pericytes within the cortex and striatum of the brain. The comorbidity between UCMS and MetS does not exacerbate the effects of one another on GA EDD responses, but does lead to the development of other vasculopathy adaptations, which can be partially explained by alterations in NO and ROS production. Importantly, exercise training alleviates most of the negative effects of UCMS on GA function. Compared to LZR controls, EDD and EID was lower in LZR-UCMS. The OZR-Ex group had a higher EDD and EID, compared to OZR-Controls; whereas only a difference in EDD was noted between LZR-Control and LZR-Ex groups. Importantly, EDD and EID were higher in the LZR and OZR UCMS+Ex groups compared to UCMS alone. Lower NO bioavailability and higher ROS were noted in the LZR-UCMS group, but not OZR-UCMS, compared to controls. Ex and UCMS-Ex groups had higher NO bioavailability compared to control and UCMS groups, but ROS levels remained high. UCMS significantly decreased MVD in LZR-UCMS but was not changed in OZR-UCMS. In LZR-and OZR-Ex, MVD was increased and when coupled with UCMS, Ex improved MVD in both LZRand OZR-UCMS+Ex. RT-PCR showed no differences in mRNA expression between groups in any of the angiogenic and oxidative stress markers examined. Corticosterone levels were elevated in the Ex and UCMS+Ex groups vs. the controls which may, in part, reflect the slight stress induced by use of the forced treadmill Ex protocol. It has been shown that glucocorticoids can increase ROS directly, including superoxide, hydrogen peroxide, and peroxynitrite (1). Given that DHE can interact with these oxidants,...

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Unravelling the Neuroinflammatory Mechanisms Underlying the Effects of Social Defeat Stress on Use of Drugs of Abuse

Montagud‐Romero

Miñarro

Rodrı́guez-Arias

2021

Neuroscience of Social Stress

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Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole

Cited by 11 publications

References 85 publications

Wheel access has opposing effects on stress physiology depending on social environment in female prairie voles (Microtus ochrogaster)

Wheel access has opposing effects on stress physiology depending on social environment in female prairie voles (Microtus ochrogaster)

Skeletal Muscle Arteriole Dysfunction and Microvessel Density in Metabolic Syndrome and Depression: How Exercise Can Be Used as an Intervention

Unravelling the Neuroinflammatory Mechanisms Underlying the Effects of Social Defeat Stress on Use of Drugs of Abuse

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