Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice

Lee, S.; Jang, Seon Ho; Suzuki-Narita, Miyako; Grégoire, Stéphanie; Millecamps, Magali; Stone, Laura S.

doi:10.1016/j.joca.2021.06.014

Cited by 16 publications

(16 citation statements)

References 46 publications

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“…Co-culture models of degenerated IVDs and macrophages also suggest that IVD-produced IL-1β polarizes macrophages to a pro-inflammatory phenotype [ 78 ]. Recent studies also suggest that exercise limits pain and macrophage-mediated inflammation within the disc in mouse models [ 79 ]. Broad clearance of all macrophage subsets in vivo via clodronate liposomes limits production of inflammatory cytokines when Cd11b + cells from the disc are cultured in vitro [ 80 ], but an examination of the effects of macrophage clearance on disc degeneration was not described.…”

Section: Roles Of Macrophages In Disc Degenerationmentioning

confidence: 99%

Macrophages and Intervertebral Disc Degeneration

Koroth

Buko

Abbott

et al. 2023

IJMS

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The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration is a disease of the whole joint that is associated with significant inflammation. Moreover, studies show elevated macrophage accumulation within the IVD with increasing levels of disease severity; however, we still need to understand the roles, be they causative or consequential, of macrophages during the degenerative process. In this narrative review, we discuss hallmarks of IVD degeneration, showcase evidence of macrophage involvement during disc degeneration, and explore burgeoning research aimed at understanding the molecular pathways regulating macrophage functions during intervertebral disc degeneration.

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Section: Roles Of Macrophages In Disc Degenerationmentioning

confidence: 99%

Macrophages and Intervertebral Disc Degeneration

Koroth

Buko

Abbott

et al. 2023

IJMS

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“…Enhanced production of proinflammatory molecules is observed during the pathogenesis of IVDD ( Lee et al, 2021 ). Various proinflammatory cytokines and chemokines have been reported to be associated with IVDD ( De Luca et al, 2020 ; Jacobsen et al, 2020 ), among which TNF-α has been considered a predominant factor and shown to play a detrimental role in IVDD development ( Wang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration

Wang

Zhang

Zhao

et al. 2022

Front. Bioeng. Biotechnol.

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Intervertebral disc degeneration (IVDD) is a predominant cause of disc herniation and is widespread worldwide. Inflammatory responses, mitochondrial dysfunction, and extracellular matrix degradation are known to be involved in IVDD. Scutellarin, an active ingredient extracted from Erigeron breviscapus (Vaniot) Ha, Hand-Mazz, is reported to exhibit therapeutic potential in several degenerative diseases by suppressing inflammation and regulating metabolism. However, whether scutellarin can improve IVDD remains unknown. Human primary nucleus pulposus cells (HNPCs) were cultured and stimulated with TNF-α in the presence or absence of scutellarin. Furthermore, a rat needle puncture model was established, and scutellarin was injected into the IVD to verify its protective function against IVDD. Scutellarin attenuated the inflammatory reaction and retained the production of major IVD components both in vitro and in vivo. Mechanistically, scutellarin reduced the amount of reactive oxygen species (ROS), alleviated mitochondrial damage, and decreased the expression levels of apoptosis-related biomarkers upon stimulation with TNF-α. In addition, scutellarin antagonized the activation of the nuclear factor κ-light-chain-enhancer of activated B (NF-κB) signaling pathway and the mitogen-activated protein kinase (MAPK) signaling pathway and suppressed the activity of the NLRP3 inflammasome mediated by TNF-α. This study reveals that scutellarin protects against degeneration of nucleus pulposus cells, which might shed light on treatment of IVDD in the future.

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“…The expression level of SPARC decreased with aging and intervertebral disc degeneration. Moreover, it has been demonstrated that SPARC deletion accelerates IDD in mice (98,99). Histological analysis revealed that herniations of lower lumbar discs in SPARC-null mice occur as early as 14-month-old.…”

Section: Spontaneous Model 231 Genetically Modified Mice Modelmentioning

confidence: 99%

“…Certain gene deficiency impairs intervertebral disc metabolic homeostasis and structural integrity. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein involved in the pathogenesis of IDD (98). The expression level of SPARC decreased with aging and intervertebral disc degeneration.…”

Section: Spontaneous Model 231 Genetically Modified Mice Modelmentioning

confidence: 99%

Constructing intervertebral disc degeneration animal model: A review of current models

Liang

Gao²,

Zhou³

et al. 2023

Front. Surg.

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Low back pain is one of the top disorders that leads to disability and affects disability-adjusted life years (DALY) globally. Intervertebral disc degeneration (IDD) and subsequent discogenic pain composed major causes of low back pain. Recent studies have identified several important risk factors contributing to IDD's development, such as inflammation, mechanical imbalance, and aging. Based on these etiology findings, three categories of animal models for inducing IDD are developed: the damage-induced model, the mechanical model, and the spontaneous model. These models are essential measures in studying the natural history of IDD and finding the possible therapeutic target against IDD. In this review, we will discuss the technical details of these models, the duration between model establishment, the occurrence of observable degeneration, and the potential in different study ranges. In promoting future research for IDD, each animal model should examine its concordance with natural IDD pathogenesis in humans. We hope this review can enhance the understanding and proper use of multiple animal models, which may attract more attention to this disease and contribute to translation research.

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Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice

Cited by 16 publications

References 46 publications

Macrophages and Intervertebral Disc Degeneration

Macrophages and Intervertebral Disc Degeneration

Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration

Constructing intervertebral disc degeneration animal model: A review of current models

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