Voluntary wheel-running attenuates insulin and weight gain and affects anxiety-like behaviors in C57BL6/J mice exposed to a high-fat diet

Hicks, Jasmin A.; Hatzidis, Aikaterini; Arruda, Nicole L.; Gelineau, Rachel R.; Pina, Isabella Monteiro De; Adams, Kenneth W.; Seggio, Joseph A.

doi:10.1016/j.bbr.2016.04.051

Cited by 39 publications

(34 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, exercise appears to be more beneficial in improving T2DM and metabolic disorder symptoms such as insulin resistance, 15 which outcomes are verified by human studies, 33,34 even without significant weight loss. On the other hand, this study and one other 24 indicated that exercise had no effect on glucose tolerance, especially as time progressed, which may be surprising given that insulin levels are affected. The positive effects of exercise on insulin secretion might be due to its direct effect on the insulin release pathways and its conversion into active forms.…”

Section: Discussionmentioning

confidence: 66%

“…The current study and others 15,24 show that voluntary wheel-running and forced exercise 17,18 via a treadmill or motorized running-wheel demonstrate moderate improvements comparable to each other regarding obesity and T2DM symptoms in exercising rodents consuming a high-fat diet. One study using rats examining both forced and voluntary exercise simultaneously illustrated that regardless of exercise method, exercise produces improvements in insulin resistance.…”

Section: Discussionmentioning

confidence: 95%

“…While most DIO models consume additional kcals on a high-fat diet, 3,20 the mice in the current study and one other did not, 24 yet were still obese compared to the controls. These results indicate that it is not just the increase in calories consumed that can lead to obesity in these DIO mice but food composition as well.…”

Section: Discussionmentioning

confidence: 96%

“…Type-2 diabetics are known to have increased inactive insulin and proinsulin, 35 while wheel-running produces reductions in pancreatic proinsulin mRNA in rats. 36 This reduction in proinsulin secretion might be the mechanism behind the reduced hyperinsulinemia seen in exercising individuals as insulin levels drop, whereas c-peptide levels remain similar between sedentary and exercising animals 24 and humans. 37 The unchanged levels of c-peptide or active insulin could be the reason why overall insulin levels are affected by exercise, but not glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

“…30 The current study and other reports illustrate that exercise alone can produce minimal, though statistically significant, improvements in some T2DM symptoms in rodents fed a high-fat diet. 15,24 Wheelrunning can also alleviate T2DM symptoms in mice selectively-bred 31 or genetically altered 32 for T2DM. However, the effects of exercise on obesity may be few at best, as multiple studies report only small improvements in the animal and human literature.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

Hatzidis

Hicks

Gelineau

et al. 2017

View full text Add to dashboard Cite

ObJeCTIVe: both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a lowfat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DeSIgN: Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. ReSUlTS: Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (p=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (p=0.999) or in controls (p=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (p=0.012) and leptin (p <0.001), glucose tolerance (p <0.001), and obesity (p <0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch (p=0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets (p=0.516). CONCLUSIONS: These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

Hatzidis

Hicks

Gelineau

et al. 2017

View full text Add to dashboard Cite

show abstract

The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background and ObjectiveAnimal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different “lifestyle variables” such as diets. Consumption of both high‐fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high‐fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice.MethodMice were separated into three food groups: high‐fat diet, 10% fat diet, and regular chow, and each group was paired with either water or 10% alcohol. Behavioral assays included diet and alcohol preference, light‐dark box, open field, and feeding and drinking measurements. Physiological measures included glucose tolerance tests and measurement of brain‐derived neurotrophic factor, insulin, and leptin levels.ResultsFemales and males differed in the open field, as male mice decreased activity, while females increased activity when consuming high‐fat diet. While females consumed more ethanol than males, alcohol consumption was able to improve glucose tolerance and increase anxiety in both sexes. Lastly, females were more resistant to the physiological changes caused by high‐fat diet than males, as females consuming high‐fat diet exhibited decreased insulin secretion, less change to brain‐derived neurotrophic factor levels, and better glucose tolerance than males consuming high‐fat diet.ConclusionThese results suggest that the response to high‐fat diet and alcohol consumption is sex dependent and that males are more affected both behaviorally and physiologically by high‐fat diet compared to females.

show abstract

Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets

Wang

Guo

2022

Cancer Metastasis Rev

View full text Add to dashboard Cite

Voluntary wheel-running attenuates insulin and weight gain and affects anxiety-like behaviors in C57BL6/J mice exposed to a high-fat diet

Cited by 39 publications

References 72 publications

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice

Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets

Contact Info

Product

Resources

About