Voluntary wheel running mitigates the stress-induced bone loss in ovariectomized rats

Lertsinthai, Parinya; Charoenphandhu, Jantarima; Suntornsaratoon, Panan; Krishnamra, Nateetip; Charoenphandhu, Narattaphol

doi:10.1007/s00774-014-0597-3

Cited by 5 publications

(8 citation statements)

References 42 publications

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“…In contrast to our study, decreased bone mass was reported in mice following exposure to chronic mild stress ( Yirmiya et al, 2006 ; Furuzawa et al, 2014 ; Azuma et al, 2015 ; Lertsinthai et al, 2015 ), an accepted stress model for inducing a depressive-like phenotype and increased plasma GC and NE concentrations. Because GCs are established inhibitors of bone formation by increasing osteoblast and decreasing osteoclast apoptosis ( Weinstein et al, 2004 , 1998 ; O'Brien et al, 2004 ), the difference in the HPA axis activity might contribute to the different effects of CSC and chronic mild stress on bone metabolism and formation.…”

Section: Discussioncontrasting

confidence: 99%

Chronic psychosocial stress disturbs long-bone growth in adolescent mice

Foertsch¹,

Haffner‐Luntzer²,

Kroner³

et al. 2017

Disease Models &Amp; Mechanisms

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Although a strong association between psychiatric and somatic disorders is generally accepted, little is known regarding the interrelationship between mental and skeletal health. Although depressive disorders have been shown to be strongly associated with osteoporosis and increased fracture risk, evidence from post-traumatic stress disorder (PTSD) patients is less consistent. Therefore, the present study investigated the influence of chronic psychosocial stress on bone using a well-established murine model for PTSD. C57BL/6N mice (7 weeks old) were subjected to chronic subordinate colony housing (CSC) for 19 days, whereas control mice were singly housed. Anxiety-related behavior was assessed in the open-field/novel-object test, after which the mice were euthanized to assess endocrine and bone parameters. CSC mice exhibited increased anxiety-related behavior in the open-field/novel-object test, increased adrenal and decreased thymus weights, and unaffected plasma morning corticosterone. Microcomputed tomography and histomorphometrical analyses revealed significantly reduced tibia and femur lengths, increased growth-plate thickness and reduced mineral deposition at the growth plate, suggesting disturbed endochondral ossification during long-bone growth. This was associated with reduced Runx2 expression in hypertrophic chondrocytes in the growth plate. Trabecular thicknesses and bone mineral density were significantly increased in CSC compared to singly housed mice. Tyrosine hydroxylase expression was increased in bone marrow cells located at the growth plates of CSC mice, implying that local adrenergic signaling might be involved in the effects of CSC on the skeletal phenotype. In conclusion, chronic psychosocial stress negatively impacts endochondral ossification in the growth plate, affecting both longitudinal and appositional bone growth in adolescent mice.

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Section: Discussioncontrasting

confidence: 99%

Chronic psychosocial stress disturbs long-bone growth in adolescent mice

Foertsch¹,

Haffner‐Luntzer²,

Kroner³

et al. 2017

Disease Models &Amp; Mechanisms

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“…An alternative therapy is physical exercise. Weight-bearing exercise, high-impact exercise, and resistance training appear to have beneficial effects on bone in humans and animal models [21,22]. Exercise is more effective in the growing bones, and it increases bone mass in pre-and peripubertal adolescents [23][24][25][26].…”

Section: Introductionmentioning

confidence: 96%

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength

Zhang

Chen

et al. 2016

J Bone Miner Metab

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Physical exercise is beneficial to bone health. However, little is known how different intensities of exercise affect bone mass and strength. In the present study, we used young mice to study the effects of different intensities of exercise on bone mass and bone strength in comparison to pharmacological doses of active vitamin D (calcitriol). We found that only the medium level of exercise tested showed a positive effect on bone mineral density, trabecular bone volume, and bone strength, which are attributable to a decrease in bone resorption and an increase in bone formation, with the latter being accompanied by an increase in the number of osteogenic mesenchymal stem cells in the bone marrow. Calcitriol increases bone volume and bone strength, yet the combination of calcitriol and medium-intensity exercise did not further improve bone mass or strength. Moreover, calcitriol also showed some protective effect on the bone in mice with high levels of exercise. These results indicate that exercise at medium intensity increases bone mass and strength via affecting both bone formation and resorption and that its beneficial effects on bone mass cannot be further improved by calcitriol.

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“…Lertsinthai et al investigated whether a voluntary wheel running program can rescue a four week –CAS (Chronic Aversive Stimuli) exposure on trabecular bone loss in eight-weeks-old OVX rats. At the sacrifice, they have shown that the active erosion surface (a.ES/BS) was lower in the OVX + CAS + running condition vs. the OVX + CAS group, which shows that wheel running had positive effects on osteoclast parameters in these 13-week-old OVX rats submitted to chronic aversive stimuli [ 159 ].…”

Section: Effects Of Physical Exercises On Bone Health Statusmentioning

confidence: 99%

“…Furthermore, for the ovariectomized female rats, as previously shown, Lertsinthai et al investigated whether a four-week CAS exposure aggravated trabecular bone loss in ovariectomized rats [ 159 ]. This CAS program included a swimming part with a swimming frequency at 1 h/day, five days/week for four weeks.…”

Section: Effects Of Physical Exercises On Bone Health Statusmentioning

confidence: 99%

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Does Physical Exercise Always Improve Bone Quality in Rats?

Portier

Benaîtreau

Pallu

2020

Life

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For decades, the osteogenic effect from different physical activities on bone in rodents remained uncertain. This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality. The bone parameters presented are bone mineral density, micro-architectural and mechanical properties, and osteoblast/osteocyte and osteoclast parameters. This review shows that physical activities have a positive effect (65% of the results) on bone status, but we clearly observed a difference amongst the different protocols. Even if treadmill running is the most used protocol, the resistance training constitutes the first exercise model in term of osteogenic effects (87% of the whole results obtained on this model). The less osteogenic model is the vibration mode procedure (31%). It clearly appears that the gender plays a role on the bone response to swimming and wheel running exercises. Besides, we did not observe negative results in the osteopenic population with impact training, wheel running and vibration activities. Moreover, about osteoblast/osteocyte parameters, we conclude that high impact and resistance exercise (such jumps and tower climbing) seems to increase bone formation more than running or aerobic exercise. Among the different protocols, literature has shown that the treadmill running procedure mainly induces osteogenic effects on the viability of the osteocyte lineage in both males and females or ovariectomized rats; running in voluntary wheels contributes to a negative effect on bone metabolism in older male models; whole-body vertical vibration is not an osteogenic exercise in female and ovariectomized rats; whereas swimming provides controversial results in female models. For osteoclast parameters only, running in a voluntary wheel for old males, the treadmill running program at high intensity in ovariectomized rats, and the swimming program in a specific ovariectomy condition have detrimental consequences.

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Voluntary wheel running mitigates the stress-induced bone loss in ovariectomized rats

Cited by 5 publications

References 42 publications

Chronic psychosocial stress disturbs long-bone growth in adolescent mice

Chronic psychosocial stress disturbs long-bone growth in adolescent mice

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength

Does Physical Exercise Always Improve Bone Quality in Rats?

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