Von Frey's hairs – a review of their technology and use – a novel automated von Frey device for improved testing for hyperalgesia

Lambert, Geoffrey; Mallos, George; Zagami, Alessandro S

doi:10.1016/j.jneumeth.2008.10.033

Cited by 67 publications

(46 citation statements)

References 37 publications

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“…The centre of each cutaneous RF was stimulated mechanically with an automated von Frey device, as previously described (26). Intermittent single von Frey stimuli were applied by activating the device from a stimulator which was in turn driven by the data-acquisition software.…”

Section: Methodsmentioning

confidence: 99%

Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system

2011

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These results suggest that there is a continuous baseline traffic in primary trigeminovascular fibres and that CSD does not act to increase this traffic by a peripheral action alone - rather, it must produce some of its effect by a mechanism intrinsic to the central nervous system. Thus the pain of migraine may not always be the result of peripheral sensory stimulation, but may also arise by a central mechanism.

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Section: Methodsmentioning

confidence: 99%

Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system

2011

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“…17 Von-frey monofilamentler: Yumuşak fırça darbeleriyle hastanın temas algısını ölçmede kullanılırlar. 18 Pinprick testi: 22 veya 23 gauge iğne ile ağrıya cevap ölçülür. 19 Termal test: Radyan ısı kaynağı veya etil kloritli pamuk parçası, mümkün olduğunca çabuk deriye değdirilir ve tepki ölçülür.…”

Section: Klinik Hassasiyet Testleriunclassified

Di̇ş Heki̇mli̇ği̇nde Peri̇feri̇k Si̇ni̇r Yaralanmalari Ve Tedavi̇si̇

Er¹,

Duygu²,

Çanakçi³

et al. 2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZDiş hekimliğinde periferik sinir yaralanmaları, rutin işlemler sırasında, cerrahi uygulamalarda veya travma sonucunda sıklıkla karşılaşılan olgulardır. Sinirin yapısı ve sinir hasarı mekanizmaları konusunda bilgi sahibi olmak, doğru teşhis ve tedavi için oldukça önemlidir. Sinir yaralanmalarının tedavisi, temel olarak medikal tedavi ve cerrahi tedavi olarak ikiye ayrılır. Medikal tedavinin sonuç vermediği hastalarda, muhtemel cerrahi tedavi için seçenek ve sonuçlarını bilmek, bu kritik komplikasyonda, doğru zamanlama ve uygulama açısından büyük önem arz etmektedir. Bu derlemenin amacı; diş hekimliği klinik uygulamalarında karşılaşıla-bilecek periferik sinir yaralanmaları sebeplerini hatırlamak ve mevcut kitap bilgileri ile güncel literatür bilgilerini harmanlayarak bu önemli komplikasyon hakkında bilgi sahibi olmaktır. Anahtar kelimeler: diş hekimliği; medikal tedavi; periferik sinir yaralanması; sinir cerrahisi GĠRĠġSinir sistemi iç ve dış ortamda oluşan değişik-liklere ani yanıtın oluşturulduğu sistemdir. İç ortamda oluşan değişiklikleri düz kas, kalp kası ve salgı bezlerine gönderdiği emirlerle düzenleyip kontrol ederken; dış ortamda oluşan değişikliklere iskelet kaslarına emir göndererek yanıt verir. 1 İnsan vücudunda, sinir sistemi; merkezi sinir sistemi (MSS) ve periferik (çevresel) sinir sistemi (PSS) olarak iki kısımda incelenir.PSS'yi oluşturan sinirler horizontal kesitte içten dışa doğru incelendiğinde en dışta arter, ven ve lenfa- ABSTRACTPeripheral nerve injuries are frequently seen during routine procedures, surgical operations or after traumas in dentistry. Knowledge about the structure of the nerve tissue and nerve damage mechanisms is important for accurate diagnosis and treatment. Management of nerve injury is basically divided in two as medical and surgical treatment. It has a great importance to be aware of surgical treatment options and their possible results for correct timing and treatment in patients who do not respond to medical therapy. The purpose of this review is to to have information about peripheral nerve injuries and recent treatment approaches in clinical dental practice combining the book information and current literature. Key words: dentistry; peripheral nerve injury; medical treatment; surgical treatment tiklerin bulunduğu gevşek yapısı ile siniri dış etkenlere karşı koruyan epinöriyum tabakası görülür. Hemen altındaki perinöriyum, fasikül adı verilen akson demetlerini saran kuvvetli bir bağ dokusu olup, travma ve iskemiye karşı çok dayanıklıdır ve bu bariyerin bozulması halinde sinir iletimi önemli ölçüde etkilenir. Endonöriyum ise sinir liflerini çevreleyen gevşek bağ dokusu olup, içerisinde aksonlar, Schwann hücreleri, kollajen lifler, fibroblastlar, kapiller damarlar ve az sayıda mast hücresi ile makrofajlar vardır. Fasikül ise periferik sinirin en küçük anatomik birimi olup, cerrahi olarak diseke edilebilir ve görülebilir. 2

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“…However, determining the sensitivity of the orofacial regions of a rodent can be difficult using some common methods. As an example, fixed stimulus and investigator driven devices can be used to determine tolerance thresholds in the orofacial region based on animal reaction to stimuli (Imamura et al, 1997; Krzyzanowska et al, 2011; Morris et al, 1982; Rosenfeld et al, 1978; Vos and Strassman, 1994); however, variations in reaction scoring criteria between experimenters, animal stress due to handling and restraint, and differences in protocols can limit the sensitivity of these methods and confound the results (Chesler et al, 2002; Hogan et al, 2004; Lambert et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats

Rohrs

Kloefkorn

Lakes

et al. 2015

Journal of Neuroscience Methods

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Background Detecting behaviors related to orofacial pain in rodent models often relies on subjective investigator grades or methods that place the animal in a stressful environment. In this study, an operant-based behavioral assay is presented for the assessment of orofacial tactile sensitivity in the rat. New Methods In the testing chamber, rats are provided access to a sweetened condensed milk bottle; however, a 360° array of stainless steel wire loops impedes access. To receive the reward, an animal must engage the wires across the orofacial region. Contact with the bottle triggers a motor, requiring the animal to accept increasing pressure on the face during the test. To evaluate this approach, tolerated bottle distance was measured for 10 hairless Sprague-Dawley rats at baseline and 30 minutes after application of capsaicin cream (0.1%) to the face. The experiment was repeated to evaluate the ability of morphine to reverse this effect. Results The application of capsaicin cream reduced tolerated bottle distance measures relative to baseline (p<0.05). As long as morphine did not cause reduced participation due to sedation, subcutaneous morphine dosing reduced the effects of capsaicin (p<0.001). Comparison with Existing Method For behavioral tests, experimenters often make subjective decisions of an animal’s response. Operant methods can reduce these effects by measuring an animal’s selection in a reward-conflict decision. Herein, a method to measure orofacial sensitivity is presented using an operant system. Conclusions This operant device allows for consistent measurement of heightened tactile sensitivity in the orofacial regions of the rat.

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Von Frey's hairs – a review of their technology and use – a novel automated von Frey device for improved testing for hyperalgesia

Cited by 67 publications

References 37 publications

Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system

Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system

Di̇ş Heki̇mli̇ği̇nde Peri̇feri̇k Si̇ni̇r Yaralanmalari Ve Tedavi̇si̇

A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats

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