von Willebrand factor and cancer: A renewed interest

Franchini, Massimo; Frattini, Francesco; Crestani, Silvia; Bonfanti, Carlo; Lippi, Giuseppe

doi:10.1016/j.thromres.2013.01.015

Cited by 80 publications

(82 citation statements)

References 31 publications

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“…In addition, vWf might have pro-apoptotic properties, and it might reduce metastases by inducing tumor cell death [20,22]. This could be indirectly detected from our results, thus high proportion of lymphatic vessels to all vessels predicts poor survival.…”

Section: Discussionmentioning

confidence: 58%

“…Previous studies have indicated that the cells of the immune system might prevent the cancer from spreading through the blood vessels [20]. In addition, vWf might have pro-apoptotic properties, and it might reduce metastases by inducing tumor cell death [20,22].…”

Section: Discussionmentioning

confidence: 99%

“…However, in our study, the vessels stained by vWf did not predict better prognosis. Some other studies have suggested that the interaction between tumor cells and coagulation cascade factors (such as vWf) and/or platelets might promote invasiveness and metastasis capacity of cancer cells [20,[41][42][43][44]. Hence, the role of blood and lymphatic vessels in cancers remains unsolved, and additional studies are needed.…”

Section: Discussionmentioning

confidence: 99%

“…vWf is expressed by blood endothelium and also weakly expressed on lymphatic endothelium [14][15][16][17][18][19]. Results about vWf expression in cancers are ambivalent [20]. Studies have shown that colorectal and gastric cancers have a higher density of vWf stained vessels than healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

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High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Seppälä

Pohjola

Laranne

et al. 2016

Eur Arch Otorhinolaryngol

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Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in tongue cancer. Paraffin-embedded tongue and lymph node specimens (n = 113) were stained immunohistochemically with a polyclonal antibody von Willebrand factor, recognizing blood and lymphatic endothelium and with a monoclonal antibody podoplanin, recognizing lymphatic endothelium. The relative density of lymphatic vessels was counted by dividing the mean number of lymphatic vessels per microscopic field (podoplanin) by the mean number of all vessels (vWf) per microscopic field. The high relative density of lymphatic vessels (≥80 %) was associated with poor prognosis in tongue cancer. The relative density of lymphatic vessels predicted poor prognosis in the group of primary tumor size T1-T2 and in the group of non-metastatic cancer. The lymphatic vessel density and diameter of lymphatic vessels were not associated with tongue cancer survival. The relative density of lymphatic vessels might have clinically relevant prognostic impact. Further studies with increased number of patients are needed.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Seppälä

Pohjola

Laranne

et al. 2016

Eur Arch Otorhinolaryngol

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“…Angiogenesis is also critical for tumor formation, and therefore the altered expression of VWF found in our study is not surprising. Recently, the direct antitumor effect of VWF by negative modulation of apoptosis was suggested by Franchini et al 52 ( Figure 1). It is known that the plasma level of VWF increases in malignancy and is the result of adverse changes in the endothelium.…”

Section: Downregulated Proteinsmentioning

confidence: 88%

Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia

Reichert

2017

Exp Biol Med (Maywood)

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The submitted manuscript provides new data on the molecular mechanisms of BLVinduced tumorigenic process indicating the potential marker proteins both for monitoring the progression of the disease and as possible targets of pharmacological intervention. This is to my knowledge the first study of the proteome of the transformed lymphocytes in the course of bovine leukemia virus-induced leukemia in susceptible animals. BLV can be considered as useful model for related human pathogen -HTLV-1, another member of the deltaretrovirus genus evolutionary closely related to BLV. Information gathered in this study can be useful to speculate on possible shared mechanisms of deltaretrovirus-induced carcinogenesis. AbstractPresented are the results of a study of the expression pattern of different proteins in the course of bovine leukemia virus-induced leukemia in experimental sheep and I discuss how the obtained data may be useful in gaining a better understanding of the pathogenesis of the disease, diagnosis, and for the selection of possible therapeutic targets. In cattle, the disease is characterized by life-long persistent lymphocytosis leading to leukemia/lymphoma in about 5% of infected animals. In sheep, as opposed to cattle, the course of the disease is always fatal and clinical symptoms usually occur within a three-year period after infection. For this reason, sheep are an excellent experimental model of retrovirus-induced leukemia. This model can be useful for human pathology, as bovine leukemia virus is closely related to human T-lymphotropic virus type 1. The data presented here provide novel insights into the molecular mechanisms of the bovine leukemia virus-induced tumorigenic process and indicate the potential marker proteins both for monitoring progression of the disease and as possible targets of pharmacological intervention. A study of the proteome of B lymphocytes from four leukemic sheep revealed 11 proteins with altered expression. Among them, cytoskeleton and intermediate filament proteins were the most abundant, although proteins belonging to the other functional groups, i.e. enzymes, regulatory proteins, and transcription factors, were also present. It was found that trypsin inhibitor, platelet factor 4, thrombospondin 1, vasodilatorstimulated phosphoprotein, fibrinogen alpha chain, zyxin, filamin-A, and vitamin D-binding protein were downregulated, whereas cleavage and polyadenylation specificity factor subunit 5, non-POU domain-containing octamer-binding protein and small glutamine-rich tetratricopeptide repeat-containing protein alpha were upregulated. Discussed are the possible mechanisms of their altered expression and its significance in the bovine leukemia virus-induced leukemogenic process.

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Pereyra

Starlinger

2018

Hepatology

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von Willebrand factor and cancer: A renewed interest

Cited by 80 publications

References 31 publications

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia

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