Von willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases

Kłoczko, Janusz; Kuryliszyn-Moskal, Anna; Bernacka, K; Bielawiec, M; Cylwik, Bogdan; Radziwon, Piotr

doi:10.1007/bf02229862

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…Numerous pathologic states cause an increase in the circulating concentrations of vWf:Ag, which can be used as an indicator of endothelial cell dysfunction. Plasma vWf:Ag is elevated in a variety of diseases characterized by vascular damage, including vasculitis [15], atherosclerosis, pulmonary hypertension [16], sepsis [2][3][4], end-stage renal failure [17], hepatic failure [18], ischemic heart disease and myocardial infarction [19]. Activated platelets may occasionally contribute to the circulating pool of vWf:Ag in thrombotic disorders but platelet vWf:Ag after release from · granules tends to remain bound to the platelet surface.…”

Section: Discussionmentioning

confidence: 99%

von Willebrand Factor Antigen as a Prognostic Marker in Posttraumatic Acute Lung Injury

Siemiątkowski¹,

Kłoczko

Galar

et al. 2000

Pathophysiol Haemos Thromb

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The specific endothelial cell product von Willebrand factor antigen (vWf:Ag) was measured in plasma and lung function tests were carried out and the following lung injury parameters measured: P_aO₂/F_iO₂ ratio, static respiratory compliance and Murray’s lung injury score (LIS) in a follow-up study of 36 severely traumatized patients. Injury severity score (ISS) and APACHE II scores were calculated. Patients were classified according to the presence or absence of acute respiratory distress syndrome (ARDS) complications and survival versus death. Data collection was performed on admission to hospital and after 1–3, 5, 7, 10 days of ICU stay. On all of the occasions investigated, plasma vWf:Ag levels in ARDS patients and nonsurvivors were significantly greater than those in patients without ARDS and survivors, respectively. Significant correlations were observed between initial vWf:Ag concentration and ISS, APACHE II, LIS. Our study suggests that increased concentrations of vWf:Ag in plasma are predictive of the development of ARDS and signal poor prognosis in patients following severe trauma.

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Section: Discussionmentioning

confidence: 99%

von Willebrand Factor Antigen as a Prognostic Marker in Posttraumatic Acute Lung Injury

Siemiątkowski¹,

Kłoczko

Galar

et al. 2000

Pathophysiol Haemos Thromb

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“…vWF re ects the direct damage to the vessel wall in vasculitis, yet it is not speci c to vasculitis and has been reported to be elevated in various autoimmune rheumatic diseases including rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus (30), as well as in cardiovascular disease (31) peripheral vascular disease (32), and bacterial and viral infections including COVID-19 (33). Hence, while vWF Ag may be useful in monitoring vasculitis, it cannot be used to diagnose vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Von Willebrand factor: a possible biomarker for disease activity in vasculitis

Keret,

Mazareeb,

Snir

et al. 2024

Scandinavian Journal of Rheumatology

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Background:In ammation markers commonly used to evaluate disease activity in vasculitis, C-reactive protein (CRP) and sedimentation rate, are often normal despite active disease. Von -Willebrand factor (vWF), is synthesized primarily in endothelial cells and secreted in response to vascular damage. Sporadic reports suggested increased vWF levels in vasculitis. Aim:To evaluate vWF serum concentration in patients with vasculitis as a marker of disease activity. Methods:Adult patients with systemic vasculitis were prospectively enrolled. Disease activity was recorded using the Birmingham Vasculitis Activity Score (BVAS) v3. Blood group adjusted vWF antigen serum level was evaluated at diagnosis and when available after treatment. Results:Twenty-ve patients with systemic vasculitis were compared to 15 healthy controls. The mean age of patients was 56 ± 17 years and 56% were women. 40% had ANCA-associated vasculitis; 20% had giant cell arteritis; 16% had polyarteritis nodosa; 8% had Takayasu arteritis and the rest had other vasculitides.The mean disease duration was 3.4 ± 4.8 years. Mean vWF was higher in patients with active vasculitis compared to patients in remission or low disease activity state and healthy controls-212%±81, 159%±80, and 106%±26, respectively. vWF levels directly correlated with BVAS. In 13 patients with active vasculitis who reached remission or LDA after treatment, vWF level at follow-up decreased signi cantly. In 3/5 patients who were treated with IL-6 inhibitors, vWF was elevated despite normal CRP levels, while clinically vasculitis was active. Conclusion:vWF Ag serum level is increased in active vasculitis and is suggested as a biomarker for disease activity. Key points * Traditional (CRP / ESR) in ammatory markers may fail to re ect active in ammation in patients with vasculitis. * Von -Willebrand factor is directly related to endothelial damage. * Von -Willebrand factor is elevated in patients with active vasculitis, and is correlated with disease activity as measured by BVAS score.* Von-Willebrand factor levels may serve as an additional biomarker for monitoring disease activity and treatment response.

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“…An increased liberation of vWf to circulation is followed by endothelial damage [ 38 ]. The elevated concentration of vWf has been found in diseases such as atherosclerosis, diabetes, rheumatoid vasculitis where damage to the endothelium is observed [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

Budzyń

Iskra

Turkiewicz³

et al. 2018

PLoS ONE

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BackgroundAlthough the endothelial dysfunction is considered to be implicated in the pathogenesis of chronic venous insufficiency (CVI) the endothelial status in patients with venous disorders is still not fully evaluated. Therefore the aim of the study was to measure the concentration of selected markers of endothelial dysfunction: von Willebrand factor (vWf), soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM) and soluble VE-cadherin (sVE-cadherin) in CVI women who constitute the most numerous group of patients suffering from venous disease.Materials and methodsForty four women with CVI were involved in the study and divided into subgroups based on CEAP classification. Concentration of vWf, sP-selectin, sTM and sVE-cadherin were measured and compared with those obtained in 25 healthy age and sex-matched women.ResultsIt was found that the concentration of sTM increased and sVEcadherin decreased along with disease severity in CVI women. A significant rise of sTM was observed especially in CVI women, with the highest inflammation status reflected by hsCRP or elastase concentration, and in CVI women with a high oxidative stress manifested by an increased plasma MDA. A significant fall of circulating sVE-cadherin was reported in CVI women with moderate to highest intensity of inflammation and oxidative stress. There was no change in vWF and sP-selectin concentration at any stage of CVI severity.ConclusionsThe results of the present study demonstrate the presence of endothelial dysfunction in women suffering from CVI which seems to progress with the disease severity and may be associated with inflammation and enhanced oxidative stress.

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Von willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases

Cited by 10 publications

References 16 publications

von Willebrand Factor Antigen as a Prognostic Marker in Posttraumatic Acute Lung Injury

von Willebrand Factor Antigen as a Prognostic Marker in Posttraumatic Acute Lung Injury

Von Willebrand factor: a possible biomarker for disease activity in vasculitis

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

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