Multimedia data is a popular communication medium, but requires substantial storage space and network bandwidth. Vector quantization (VQ) is suitable for multimedia data applications because of its simple architecture, fast decoding ability, and high compression rate. Full-search VQ can typically be used to determine optimal codewords, but requires considerable computational time and resources. In this study, a hybrid VQ combining a tree structure and a Voronoi diagram is proposed to improve VQ efficiency. To efficiently reduce the search space, a tree structure integrated with principal component analysis is proposed, to rapidly determine an initial codeword in low-dimensional space. To increase accuracy, a Voronoi diagram is applied to precisely enlarge the search space by modeling relations between each codeword. This enables an optimal codeword to be efficiently identified by rippling an optimal neighbor from parts of neighboring Voronoi regions. The experimental results demonstrated that the proposed approach improved VQ performance, outperforming other approaches. The proposed approach also satisfies the requirements of handheld device application, namely, the use of limited memory and network bandwidth, when a suitable number of dimensions in principal component analysis is selected.