1987
DOI: 10.1002/bit.260290212
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Vortex chamber for in situ recovery of the antibiotic myxovirescin A in continuous cultivation

Abstract: A vortex chamber for continuous adsorption of the antibiotic Myxovirescin A on XAD resins was developed. In this paper the design and use of the vortex chamber in an external bypass of a continuous process is described. Compared with the normal continuous process, the specific production rate of the antibiotic is four to five times higher when the antibiotic is continuously adsorbed. A semicontinuous process could be performed by using two chambers for adsorption and regeneration alternatively.

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Cited by 20 publications
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“…In the literature, successful integrated separations of bioproducts are reported for amino acids [36] and antibiotics [37].…”
Section: Process-integrated Product Removalmentioning
confidence: 99%
“…In the literature, successful integrated separations of bioproducts are reported for amino acids [36] and antibiotics [37].…”
Section: Process-integrated Product Removalmentioning
confidence: 99%
“…In these procedures cells are first removed from the medium (Corry et al, 1993;Nielsen et al, 1988) or immobilized (Ribeiro et al, 1995). Solid adsorbent in situ recovery procedures have also been used in the presence of living cells, for instance to achieve enhanced production of antibiotics by streptomycetes (Dykstra et al, 1988;Fielder et al, 1996) or mycobacteria (Hecht et al, 1987). The addition of solid-adsorption material such as Amberlite™ XAD-4 to cultures was especially useful for adsorption of alkaloids from plant cells (Green et al, 1992;Robins et al, 1988;Williams et al, 1992).…”
Section: Introductionmentioning
confidence: 99%